Bleomycin-induced flagellate dermatitis

Mota, G.D.; Penna, Adriana M. Damasco; Soares, Regina Cláudia; Baiocchi, Otavio C. G.

doi:10.1016/j.bjhh.2014.03.001

Cited by 15 publications

(16 citation statements)

References 5 publications

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“…Antineoplastic therapy-associated flagellate erythema was initially described in oncology patients who received bleomycin by Moulin in 1970 [ 10 , 43 , 44 ]. Bleomycin, a chemotherapeutic antibiotic isolated from the soil fungus Streptomyces verticillus , inhibits the uptake of thymidine and thereby resulting in fragmentation of DNA [ 7 , 10 , 43 ]. The adverse reaction has been observed in patients with Hodgkins lymphoma [ 10 – 13 ], and germ cell tumors in both men [ 5 – 7 ] and women [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Bleomycin, a chemotherapeutic antibiotic isolated from the soil fungus Streptomyces verticillus , inhibits the uptake of thymidine and thereby resulting in fragmentation of DNA [ 7 , 10 , 43 ]. The adverse reaction has been observed in patients with Hodgkins lymphoma [ 10 – 13 ], and germ cell tumors in both men [ 5 – 7 ] and women [ 8 , 9 ]. The eruption is often associated with generalized pruritus and has a predilection to occur over bony prominence [ 7 – 9 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Trastuzumab-Associated Flagellate Erythema: Report in a Woman with Metastatic Breast Cancer and Review of Antineoplastic Therapy-Induced Flagellate Dermatoses

Cohen

2015

Dermatol Ther (Heidelb)

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IntroductionFlagellate erythema presents as erythematous, individual and intermingled, linear streaks in a whiplash-like pattern. Several conditions, including antineoplastic agents, have been associated with flagellate erythema. A woman with metastatic breast cancer who developed flagellate erythema after receiving trastuzumab is described and the features of flagellate erythema associated with other antineoplastic agents are reviewed.MethodsPubMed was used to search the following terms, separately and in combination: agent, antineoplastic, bendamustine, bleomycin, breast, cancer, chemotherapy, dermatitis, dermatosis, docetaxel, erythema, flagellate, Herceptin, pigmentation, peplomycin, therapy, and trastuzumab. All papers were reviewed and relevant manuscripts, along with their reference citations, were evaluated.ResultsThe woman’s pruritus and skin lesions promptly resolved after treatment with corticosteroids (oral and topical) and antihistamines (oral); premedication with dexamethasone prior to each subsequent trastuzumab treatment prevented recurrence of flagellate erythema. Chemotherapy-induced flagellate erythema was initially described in oncology patients who received bleomycin. In addition to trastuzumab, other antineoplastic agents that have been associated with the development of flagellate erythema include bendamustine, docetaxel, and peplomycin.ConclusionCutaneous adverse events to trastuzumab are uncommon. However, flagellate erythema should be added to the potential side effects of trastuzumab. In addition, trastuzumab should be added to the list of antineoplastic agents that may be associated with flagellate erythema.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-015-0085-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trastuzumab-Associated Flagellate Erythema: Report in a Woman with Metastatic Breast Cancer and Review of Antineoplastic Therapy-Induced Flagellate Dermatoses

Cohen

2015

Dermatol Ther (Heidelb)

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“…O metabolismo da bleomicina é realizado pela enzima hidrolase que apresenta baixos níveis nos tecidos pulmonares e na pele, levando a inferência de ser esta, a razão desses tecidos serem acometidos das reações adversas como é o caso da DF (8) . Outra possível causa dessa toxicidade sobre a pele pode ser pequenos traumas como escoriações ou pressão sobre áreas de proeminências ósseas, ou mesmo o prurido, que podem provocar aumento do fluxo sanguíneo resultando numa maior concentração de bleomicina nessas áreas, processo desencadeador das lesões (9) .…”

Section: Discussionunclassified

“…Ainda sobre essa questão, embora a bleomicina seja administrada em protocolo (ABVD) de poliquimioterapia para Linfoma de Hodgkin, a DF não é relacionada às outras drogas desse protocolo (9) .…”

Section: Discussionunclassified

“…Poucos são os relatos que informam o manejo da DF, porém o uso de anti-histamínicos e corticoides tópico e oral já foram descritos como capazes de trazer benefícios pela diminuição do prurido (9) . Referente ao desaparecimento das lesões há autores que estabelecem um período de cinco semanas após término do tratamento com a bleomicina (3) ou após descontinuidade da exposição à droga (7) .…”

Section: Discussionunclassified

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Dermatite Flagelada Induzida Por Bleomicina: Relato De Caso

Bispo

Oliveira

et al. 2015

Cogitare Enferm.

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RESUMO:A Dermatite Flagelada consiste de uma hiperpigmentação cutânea de aspecto flagelado, tendo como causa específica a bleomicina. A bleomicina é um agente quimioterápico usado no tratamento de diferentes neoplasias. O objetivo deste relato é descrever o caso de uma paciente de 31 anos de idade, em tratamento de Linfoma de Hodgkin com protocolo de Quimioterapia Antineoplásica composto por quatro drogas, dentre elas, a bleomicina, que cursou com o desenvolvimento da Dermatite Flagelada. Trata-se de um relato de caso ocorrido num hospital universitário do nordeste do Brasil em 2014. A terapia utilizada como tratamento foi uso de corticoide, o que proporcionou a remissão das lesões do tipo flagelo e permitiu a continuidade do tratamento sem necessidade de mudança do protocolo quimioterápico. A importância do estudo se deve por levantar discussão sobre os aspectos que envolvem o manejo dessa hipersensibilidade, para garantir a continuidade do tratamento antineoplásico. DESCRITORES:Erupção por droga; Protocolos de quimioterapia combinada antineoplásica; Doença de Hodgkin. BLEOMYCIN-INDUCED FLAGELLATE DERMATITIS: A CASE REPORTABSTRACT: Flagellate Dermatitis consists of cutaneous hyperpigmentation with a flagellate appearance, one specific cause of which is bleomycin. Bleomycin is a chemotherapy agent used in the treatment of different neoplasias. This report's objective is to describe the case of a 31-year-old patient receiving treatment for Hodgkin Lymphoma with a protocol of Antineoplastic Chemotherapy made up of four drugs, including bleomycin, which led to the development of Flagellate Dermatitis. This is a report of a case which took place in a teaching hospital in the Northeast of Brazil in 2014. The therapy used as treatment was use of corticosteroid, which led to the remission of the lesions of the flagellate type and allow the continuation of the treatment without the need for changing the chemotherapy protocol. The study's importance lies in that it raises discussion regarding the aspects involving the management of this hypersensitivity so as to ensure the continuity of the antineoplastic treatment.

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Bleomycin

2015

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Bleomycin-induced flagellate dermatitis

Cited by 15 publications

References 5 publications

Trastuzumab-Associated Flagellate Erythema: Report in a Woman with Metastatic Breast Cancer and Review of Antineoplastic Therapy-Induced Flagellate Dermatoses

Trastuzumab-Associated Flagellate Erythema: Report in a Woman with Metastatic Breast Cancer and Review of Antineoplastic Therapy-Induced Flagellate Dermatoses

Dermatite Flagelada Induzida Por Bleomicina: Relato De Caso

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