Analgesic and hemodynamic effects of intravenous infusion of magnesium sulphate versus dexmedetomidine in patients undergoing bilateral inguinal hernial surgeries under spinal anesthesia: a randomized controlled study

Farouk, Inas; Hassan, Mohamed M.; Fetouh, Ahmed Mohamed; Elgayed, Abd Elhay Abd; Eldin, Mona Hossam; Abdelhamid, Bassant Mohamed

doi:10.1016/j.bjane.2021.02.004

Cited by 2 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The primary outcome was total duration of analgesia and, the secondary outcomes were onset and duration of motor and sensitive blocks, perioperative hemodynamic status (blood pressure, heart rate, cardiac output, and systolic volume), and postoperative morphine consumption during the first 24 hours. 15 Duration of sensitive and motor blocks, and of analgesia was longer for the groups receiving magnesium sulphate or dexmedetomidine, when compared to the group receiving saline. No differences were observed for the groups that received active treatments.…”

mentioning

confidence: 88%

Magnesium: the underestimated ion

Módolo

Barros

2021

Brazilian Journal of Anesthesiology (English Edition)

View full text Add to dashboard Cite

mentioning

confidence: 88%

Magnesium: the underestimated ion

Módolo

Barros

2021

Brazilian Journal of Anesthesiology (English Edition)

View full text Add to dashboard Cite

“…Magnesium sulphate (MgSO4) has been suggested as a potential analgesic agent in various surgical procedures like abdominal hysterectomy, hysteroscopy, arthroscopic knee surgery, inguinal hernia surgery cholecystectomy, and even spine surgeries [2][3][4][5][6][7][8]. It has also been found to reduce the consumption of anaesthetic agents, blunt the sympathetic response to laryngoscopy and intubation, and enhance the effect of neuromuscular blockers.…”

Section: Introductionmentioning

confidence: 99%

Analgesic Effects of Magnesium Sulphate as an Adjuvant to Fentanyl for Monitored Anaesthesia Care During Hysteroscopy

Mishra¹,

Jain²,

Purohit³

et al. 2023

Cureus

View full text Add to dashboard Cite

Background: Magnesium sulphate (MgSO4) is conventionally used in the treatment of eclampsia, refractive arrhythmias, asthma, etc. In our study, we aimed to study the analgesic effects of MgSO4 as an adjuvant to fentanyl and reduce the intraoperative opioid requirement to decrease their adverse effects. Methods: A total of 122 patients scheduled for hysteroscopy were randomly divided into two groups. Patients in the magnesium group (group A) received intravenous MgSO4 50 mg/kg in 100 ml of isotonic saline over 15 minutes before anaesthesia induction and then 15 mg/kg per hour by continuous intravenous infusion. Patients in the control group (group B) received an equal volume of isotonic saline as a placebo. All the patients were induced with fentanyl and propofol. Perioperative haemodynamic monitoring and postoperative assessment of pain were done. Results: Only 18% of the patients in group A required rescue analgesics as compared to 39.3% of patients in group B. The patients receiving MgSO4 displayed lower verbal numeric rating scale scores in the postoperative period. In addition, the intraoperative requirement of fentanyl (101 (21.33) vs. 144 (28.4) µg, mean (SD)) and propofol (121 (13.3) vs. 140 (16.5) mg, mean (SD)) was significantly lower in group A as compared to that in group B. Conclusion: MgSO4, when administered as an adjuvant to opioids, provided effective postoperative analgesia thereby reducing the need for rescue analgesics. It also decreases intraoperative fentanyl consumption and its dose-related side effects.

show abstract

Analgesic and hemodynamic effects of intravenous infusion of magnesium sulphate versus dexmedetomidine in patients undergoing bilateral inguinal hernial surgeries under spinal anesthesia: a randomized controlled study

Cited by 2 publications

References 26 publications

Magnesium: the underestimated ion

Magnesium: the underestimated ion

Analgesic Effects of Magnesium Sulphate as an Adjuvant to Fentanyl for Monitored Anaesthesia Care During Hysteroscopy

Contact Info

Product

Resources

About