Comparison of palonosetron-dexamethasone and ondansetron-dexamethasone for prevention of postoperative nausea and vomiting in middle ear surgery: a randomized clinical trial

Srivastava, VK; Khan, Saima; Agrawal, Sanjay; Deshmukh, Sweta Anil; Shree, Pooja; Misra, Partha Pratim

doi:10.1016/j.bjane.2020.08.001

Cited by 4 publications

(6 citation statements)

References 23 publications

(22 reference statements)

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“…Em linhas gerais o tratamento medicamentoso é baseado na escala de riscos sendo que, aqueles com alto risco necessitam de uma combinação de medicamentos antieméticos, com mecanismo de ação diferente para proporcionar melhor profilaxia e menos efeitos colaterais de cada medicamento, devendo ser envolvidos nessas decisões as características individuais, o tipo de anestesia e cirurgia, bem como as reações percebidas durante o tratamento (SRIVASTAVA et al, 2020).…”

Section: Complicações Pós-operatóriasunclassified

“…N áuseas e vômitos no pós-operatório (NVPO) são fenômenos importantes e corriqueiros após cirurgias (MIRANDA et al, 2020), tendo características multifatoriais e especificidades relacionadas ao estado de saúde do paciente, ao tipo de cirurgia e da anestesia, entre outros fatores (SRIVASTAVA et al, 2020). Os estudos apontam para incidência global de náuseas e vómitos no pós-operatório entre 30% e 80% a depender das especificidades e características do caso específico (AROKE; HICKS, 2019).…”

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Complicações Pós-Operatórias

Ascari¹

2021

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Section: Complicações Pós-operatóriasunclassified

Section: Introductionunclassified

Complicações Pós-Operatórias

Ascari¹

2021

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“…There have been reports of PONV being associated with the activation of four vomiting centers, including the vestibular system, the chemoreceptor trigger area, the gastro-intestinal vagal fear system, and the cortical plaza. The vestibular system is composed of four components [ 3 ]. A multitude of neurotransmitters are responsible for transmitting nerve impulses and information from these four zones to the vomiting mall in the medulla.…”

Section: Introductionmentioning

confidence: 99%

Effect of Palonosetron on Physical Symptoms of Surgical Patients: A Systematic Review and Meta-Analysis

Chu

2022

Computational and Mathematical Methods in Medicine

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Background. Postoperative nausea and vomiting (PONV) is a typical and unpleasant physical symptom that occurs in patients after surgery, and it may be one of the most challenging elements of the recovery process. PONV can be caused by a variety of factors, including surgery itself, anesthesia, or medications. Palonosetron is a medication that is now licensed by the Food and Drug Administration for the treatment of this ailment. The efficacy of palonosetron in reducing physical symptoms in patients following surgery was investigated in this meta-analysis and comprehensive review. Methods. Following a quick search of databases such as CENTRAL, EMBASE, CINAHL, Google Scholar, the Science quotation index’s Web site, the United States clinical trial check-in, the United Kingdom clinical trial check-in, the New Zealand clinical trial check-in, and the Australia check-in, as well as outlines of major anesthesia meetings held in the previous five years, we were able to get a good start on our research. Growing adults who had surgery and were given other drugs were compared to individuals who did get palonosetron in randomized controlled trials. Results. A total of 8324 participants were recruited in 10 different clinical studies. It has been shown that palonosetron may significantly reduce the 24-hour PONV incidence and 95% confidence interval (CI) 0.41–0.86. When comparing the 6-hour and 48-hour time periods, the incidences of experiencing PONV were neither statistically different (RR: 0.82, 95% confidence interval: 0.61–1.09) or considerably different (RR: 0.60, 95% confidence interval: 0.33–1.10). Following in a similar vein, there was no significant difference between the groups in the occurrence of PONV after 48 hours (RR: 0.82, 95 percent CI: 0.59–1.14). The most often reported side effects of the medicine were headaches and dizziness, which were the most common. Regardless of the drug used, the difference in adverse reactions was not statistically significant. Conclusion. When it comes to the prevention of early PONV, it has been shown that palonosetron is more effective than other medications. Palonosetron, on the other hand, has been demonstrated to be more effective than other medications in preventing vomiting after laparoscopic surgery.

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“…In this issue of BJAN, two small but exciting clinical trials investigated the potential benefits of palonosetron in preventing the development of PONV. 9 , 10 As a second-generation 5-HT 3 receptor antagonist, palonosetron has a prolonged 40-hour half-life, allosteric binding and receptor internalization, combining both 5-HT 3 and Neurokinin-1 (NK1) receptor inhibition. Fonseca et al 9 investigated the effects of palonosetron, ondansetron and dexamethasone or dexamethasone alone in the prevention of PONV in patients undergoing laparoscopic cholecystectomy under TIVA.…”

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confidence: 99%

“…Authors showed that palonosetron was more effective than ondansetron and/or dexamethasone in preventing PONV following laparoscopic cholecystectomy. Srivastava et al 10 designed a randomized controlled trial, comparing the combination palonosetron-dexamethasone or ondansetron-dexamethasone for prevention of PONV in adult patients undergoing middle ear surgery. This randomized clinical trial enrolled 64 patients who received the prophylactic medication before anesthesia induction.…”

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confidence: 99%

Prevention of postoperative nausea and vomiting: new insights for patient care

Schmidt

2020

Brazilian Journal of Anesthesiology (English Edition)

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Comparison of palonosetron-dexamethasone and ondansetron-dexamethasone for prevention of postoperative nausea and vomiting in middle ear surgery: a randomized clinical trial

Cited by 4 publications

References 23 publications

Complicações Pós-Operatórias

Complicações Pós-Operatórias

Effect of Palonosetron on Physical Symptoms of Surgical Patients: A Systematic Review and Meta-Analysis

Prevention of postoperative nausea and vomiting: new insights for patient care

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