Effects of propofol pretreatment on myocardial cell apoptosis and SERCA2 expression in rats with hepatic ischemia/reperfusion

Yu, Su-Yeon; Guo, Yongqing; Zhang, Weiwei; Zheng, Lemin; Ren, Junming; Jin, Jianmin; Yu, Bin; Zhang, Yu; Wang, Hao; Zhang, Yuhong

doi:10.1016/j.bjane.2018.07.001

Cited by 1 publication

(1 citation statement)

References 18 publications

(16 reference statements)

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“…24 Moreover, propofol reduces apoptosis of myocardial cells induced by hepatic I/R injury in rats and upregulates mRNA and protein expression of sarcoplasmic reticulum Ca 2þ -ATPase. 25 All of these previous studies mentioned above indicate the protective effect of propofol on myocardial cells. In our study, miR-494 was highly expressed in the heart tissue of rats with hepatic I/R injury.…”

Section: Discussionmentioning

confidence: 92%

RETRACTED: Effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion injury

Zou

et al. 2021

J Int Med Res

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Objective This study aimed to investigate the effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion (I/R) injury. Methods Forty healthy adult male Sprague-Dawley rats were allocated to the sham operation group and three hepatic I/R injury groups. The I/R injury groups included I/R injury only (I/R group), treatment with propofol (propofol group), and treatment with propofol + overexpressed miR-494 (propofol+miR-494 group). Apoptosis of myocardial cells and changes in cardiac function indices, including left ventricular end-diastolic diameter, left ventricular end-systolic diameter, and left ventricular posterior wall thickness, as well as changes in miR-494, were monitored. Results The apoptotic rate of myocardial cells in the I/R group was higher, cardiac function was deteriorated, and miR-494 levels were elevated compared with the sham group. The apoptotic rate was lower, cardiac function was improved, and miR-494 levels were suppressed in the propofol group compared with the I/R group. The apoptotic rate was higher, cardiac function was deteriorated, and miR-494 levels were elevated in the propofol+miR-494 group compared with the propofol group. Conclusion Propofol plays a vital role in preventing myocardial cell apoptosis and improvement of cardiac function by suppressing miR-494 in a hepatic I/R injury rat model.

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Section: Discussionmentioning

confidence: 92%

RETRACTED: Effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion injury

Zou

et al. 2021

J Int Med Res

View full text Add to dashboard Cite

show abstract

Effects of propofol pretreatment on myocardial cell apoptosis and SERCA2 expression in rats with hepatic ischemia/reperfusion

Cited by 1 publication

References 18 publications

RETRACTED: Effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion injury

RETRACTED: Effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion injury

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