Cardiac arrest animal model: a simple device for small animals’ chest compression

Vane, Matheus Fachini; Carmona, Maria José Carvalho; Otsuki, Denise Aya; Maia, Debora R.R.; Vane, Lucas Fachini; Vane, Luiz Antonio; Filho, Elson Alberto Fernandes de Araújo; Xavier, Marcelo; Auler, José Otávio Costa

doi:10.1016/j.bjane.2017.04.005

Cited by 5 publications

(6 citation statements)

References 2 publications

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“…Previous experimental studies have evaluated the role of this receptor blockade under focal I/R injury, submitting the animals to a regimen of drug therapy prior to the CPR event or using models of isolated hearts following the Langendorf technique 15,[17][18][19][20][21] . Furthermore, most of these studies did not use angiotensin in the perfusate, precluding any conclusion about the effects of inhibiting the receptor of this enzyme.…”

Section: Discussionmentioning

confidence: 99%

Effect of AT1 receptor blockade on cardiovascular outcome after cardiorespiratory arrest: an experimental study in rats

Filho

2023

Preprint

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Background: AT1 angiotensin II receptor (ATI) antagonists are beneficial in focal ischemia/reperfusion (I/R) cases. However, in cases of global I/R, such as cardiorespiratory arrest (CRA), ATI blocker's effects are still unknown. Methods: Rats were allocated into four groups: Sham group (SG) – animals submitted to surgical interventions, without CRA; Control group (CG) – animals submitted to CRA and ventricular fibrillation; Group AT1 (GAT1) – like CG, plus 0.2 mg/kg of Candesartan; Vehicle Group (VG): animals equally induced to CRA, and administration of 0.2 ml/kg of dimethyl sulfoxide. The rate of return of spontaneous circulation (ROSC), survival, hemodynamic variables, histopathology, and markers of tissue injury were analyzed. Results: Compared to CG, the GAT1 group had a higher rate of ROSC (62.5% vs. 42.1%, p<0.0001), survival (100% vs. 62.5%, CI: 0.014-0.034; p = 0.027), lower incidence of arrhythmia after 10 minutes of ROSC, (10% vs. 62.5%, p=0.000) and lower neuronal and cardiac injury scores (p=0.025 and p=0.021, respectively). The groups did not differ regarding CRA duration, number of adrenaline doses, or number of defibrillations. Conclusion: ATI receptor blockade was responsible for higher rates of ROSC and survival, in addition to demonstrating neuronal and myocardial protection.

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Section: Discussionmentioning

confidence: 99%

Effect of AT1 receptor blockade on cardiovascular outcome after cardiorespiratory arrest: an experimental study in rats

Filho

2023

Preprint

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“…The total CPR duration was limited to 20 minutes. The initial two cycles lasted 3 minutes each, and the following cycles lasted one minute 12 ( Fig. 1 ).…”

Section: Methodsmentioning

confidence: 99%

Methylene blue as an adjuvant during cardiopulmonary resuscitation: an experimental study in rats

Xavier,

Vane,

Vieira

et al. 2024

Brazilian Journal of Anesthesiology (English Edition)

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“…Electric chest compressors have therefore been invented in recent years. Compared with manual compressions, mechanical compressions can improve organ perfusion pressure, cerebral blood flow (CBF), and ETCO 2 concentration ( Vane et al, 2017 ). There are two chest compression approaches: cardiac pump and thoracic pump.…”

Section: Factors To Consider In Establishing An Aca Rat Modelmentioning

confidence: 99%

Rat model of asphyxia-induced cardiac arrest and resuscitation

Zhu

et al. 2023

Front. Neurosci.

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Neurologic injury after cardiopulmonary resuscitation is the main cause of the low survival rate and poor quality of life among patients who have experienced cardiac arrest. In the United States, as the American Heart Association reported, emergency medical services respond to more than 347,000 adults and more than 7,000 children with out-of-hospital cardiac arrest each year. In-hospital cardiac arrest is estimated to occur in 9.7 per 1,000 adult cardiac arrests and 2.7 pediatric events per 1,000 hospitalizations. Yet the pathophysiological mechanisms of this injury remain unclear. Experimental animal models are valuable for exploring the etiologies and mechanisms of diseases and their interventions. In this review, we summarize how to establish a standardized rat model of asphyxia-induced cardiac arrest. There are four key focal areas: (1) selection of animal species; (2) factors to consider during modeling; (3) intervention management after return of spontaneous circulation; and (4) evaluation of neurologic function. The aim was to simplify a complex animal model, toward clarifying cardiac arrest pathophysiological processes. It also aimed to help standardize model establishment, toward facilitating experiment homogenization, convenient interexperimental comparisons, and translation of experimental results to clinical application.

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Cardiac arrest animal model: a simple device for small animals’ chest compression

Cited by 5 publications

References 2 publications

Effect of AT1 receptor blockade on cardiovascular outcome after cardiorespiratory arrest: an experimental study in rats

Effect of AT1 receptor blockade on cardiovascular outcome after cardiorespiratory arrest: an experimental study in rats

Methylene blue as an adjuvant during cardiopulmonary resuscitation: an experimental study in rats

Rat model of asphyxia-induced cardiac arrest and resuscitation

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