2016
DOI: 10.1016/j.bjane.2015.01.006
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Abstract: Vitamin C was observed to effectively protect chondrocytes against the toxic insult of local anesthetics ropivacaine, bupivacaine and lidocaine.

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Cited by 7 publications
(7 citation statements)
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“…The mechanism of chondrotoxic effect induced by local anesthetics remains unclear. A few studies examined ROS production by chondrocytes treated with various local anesthetics [13,14]. Other studies found that local anesthetics play a role in anti-inflammatory effects [15][16][17].…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism of chondrotoxic effect induced by local anesthetics remains unclear. A few studies examined ROS production by chondrocytes treated with various local anesthetics [13,14]. Other studies found that local anesthetics play a role in anti-inflammatory effects [15][16][17].…”
Section: Discussionmentioning
confidence: 99%
“…19 Lidocaine is more chondrotoxic than bupivacaine and ropivacaine. 20 The co-injection of hyaluronic acid (HA) suppresses chondrocytes apoptosis caused by local anesthetics. 21 However, we had five cases of rapidly progressive HOA, which we attributed to chondrolysis by lidocaine or/and by triamcinolone.…”
Section: Does This Procedures Entail Any Complication?mentioning
confidence: 99%
“…Magnesium sulphate and/or morphine, alone or in combination with various local anaesthetics, have been investigated for intra‐articular administration for treatment of postoperative joint pain (Elsharnouby et al 2008; Baker et al 2011; Elkousy et al 2013; Radwan et al 2013; Zeng et al 2016; Rubio‐Martínez et al 2017). In vitro studies of the effects of a combination of either magnesium sulphate or vitamin C and local anaesthetics on human chondrocytes indicated these drugs are able to attenuate the toxic effect of the local anaesthetics (Baker et al 2011; Tian and Li 2016). Another in vitro study found, however, that local anaesthetics alone or in combination with magnesium sulphate had cytotoxic effects on equine articular tissues (Rubio‐Martínez et al 2017).…”
Section: Duration Of Anaesthesiamentioning
confidence: 99%