Dexmedetomidine and propofol infusion on sedation characteristics in patients undergoing sciatic nerve block in combination with femoral nerve block via anterior approach

Yektaş, Abdülkadir; Gümüş, Funda; Alagöl, Ayşin

doi:10.1016/j.bjane.2014.01.003

Cited by 4 publications

(2 citation statements)

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“…Dexmedetomidine, a selective α 2 ‐adrenoreceptor agonist, has sedative, analgesic and sympatholytic features without respiratory depression . It has been suggested that it may increase the potency of local anaesthetics by both perineural and systemic administration .…”

Section: Discussionmentioning

confidence: 99%

The minimum effective concentration (MEC₉₀) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block

et al. 2016

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SummaryThe aim of this study was to determine the minimum effective concentration of ropivacaine for ultrasound-guided supraclavicular brachial plexus block. Fifty-one patients undergoing arm surgery received double-injection ultrasound-guided supraclavicular block using ropivacaine 40 ml. The concentration of ropivacaine administered to each patient started at 0.225% and then depended on the response of the previous one, based on a biased coin design upand-down sequential method. In case of failure, the ropivacaine concentration was increased by 0.025% w/v in the next subject. In the case of a successful block, the next patient was randomised to the same concentration or a concentration 0.025% w/v less. Success was defined as complete sensory blockade of the brachial plexus 30 min after the block together with pain-free surgery. The minimum effective ropivacaine concentration in 90% of subjects was 0.257% w/v (95% CI 0.241-0.280%).

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Section: Discussionmentioning

confidence: 99%

The minimum effective concentration (MEC₉₀) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block

et al. 2016

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“…where there was no hemodynamic compromise despite using a loading dose. [1920] Dinardo observed in their study that multiple bolus doses and less age are strong predictors of occurrence of the initial hypertension. [21] We did not observe hypertension in our patients.…”

Section: Discussionmentioning

confidence: 99%

The effect of intravenous dexmedetomidine compared to propofol on patients hemodynamics as a sedative in brachial plexus block: A comparative study

Kumar

Kumari

2017

Anesth Essays Res

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Background:The quest for an ideal sedative during regional anesthesia is on. Although propofol has been accepted as a sedative intraoperatively, it can be associated with troublesome hemodynamic changes. Dexmedetomidine is a new alpha 2 agonist used widely for sedation.Aims:In this study, we tried to compare equivalent doses of dexmedetomidine infusion with propofol with emphasis on their effect on the hemodynamics.Settings and Design:Prospective, single-blinded randomized controlled trial.Materials and Methods:In a single blinded study, 60 American Society of Anesthesiologists (ASA) I and II patients scheduled for forearm surgeries under brachial plexus block were randomized to receive either propofol (Group I) or dexmedetomidine (Group II) infusion. Ultrasound-guided supraclavicular brachial plexus block was given in all the patients. After confirming adequate motor and sensory blockade, they were administered an initial loading dose of the drug over 10 min followed by a maintenance dose till the end of the surgery. The rate of infusion was titrated to maintain Ramsay sedation score of 2–4. Intraoperative hemodynamic and respiratory effects were documented along with surgeon and patient satisfaction. Any adverse effect such as hypotension, bradycardia, nausea, and vomiting was also noted.Statistical Analysis Used:The data collected were evaluated using Stata version 10. P < 0.05 was considered statistically significant.Results:Heart rate decreased significantly in Group II (dexmedetomidine) while mean arterial pressure decreased significantly in Group I (propofol). There was no increase in the incidence of bradycardia or hypotension in either groups. Patient satisfaction score was significantly greater in Group II (dexmedetomidine) while surgeon satisfaction score was similar in both the groups.Conclusion:Dexmedetomidine at equivalent doses of propofol has a similar hemodynamic and respiratory effect, similar surgeon's satisfaction score, higher patient's satisfaction score, and no significant side effects in ASA I/II patients. Thus, dexmedetomidine may prove to be a valuable alternative to propofol for sedation in patients undergoing upper limb surgeries in brachial plexus block.

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Comparing Efficacy of Propofol and Dexmedetomidine in Conscious Sedation During Stapedotomy Surgery

Ayatollahi

Mansourimanesh

Hatami

et al. 2021

Indian J Otolaryngol Head Neck Surg

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Dexmedetomidine and propofol infusion on sedation characteristics in patients undergoing sciatic nerve block in combination with femoral nerve block via anterior approach

Abstract: Substitution of dexmedetomidine instead of propofol prolongs the times to start of sedation, the times to end of sedation and duration of sedation.

Cited by 4 publications

References 37 publications

The minimum effective concentration (MEC₉₀) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block

The minimum effective concentration (MEC₉₀) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block

The effect of intravenous dexmedetomidine compared to propofol on patients hemodynamics as a sedative in brachial plexus block: A comparative study

Comparing Efficacy of Propofol and Dexmedetomidine in Conscious Sedation During Stapedotomy Surgery

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Dexmedetomidine and propofol infusion on sedation characteristics in patients undergoing sciatic nerve block in combination with femoral nerve block via anterior approach

Abstract: Substitution of dexmedetomidine instead of propofol prolongs the times to start of sedation, the times to end of sedation and duration of sedation.

Cited by 4 publications

References 37 publications

The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block

The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block

The effect of intravenous dexmedetomidine compared to propofol on patients hemodynamics as a sedative in brachial plexus block: A comparative study

Comparing Efficacy of Propofol and Dexmedetomidine in Conscious Sedation During Stapedotomy Surgery

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The minimum effective concentration (MEC₉₀) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block

The minimum effective concentration (MEC₉₀) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block