Comparison of the effects of dexmedetomidine administered at two different times on renal ischemia/reperfusion injury in rats

Abstract

The results were shown that administration of dexmedetomidine reduced the renal IR injury histomorphologically. Administration of dexmedetomidine in the reperfusion period was considered as more effective due to increase in urinary output and decrease in BUN levels.

Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?

“…An increase in the concentration of antiapoptotic proteins and reduction in necrotic cell death caused as a result of decreased sympathetic tone by dex are the other possible underlying mechanisms 32. Our finding is similar to other authors’ reports in murine models,30,31 but there are also clinical studies32 reporting unfavorable notifications about dex. Most of these trials, which were performed in cardiac surgery patients, had indicated no influence of dex on renal functions 25,33.…”

“…Besides, plasma NGAL levels were comparable between dex-treated and sham groups at all measurement times. This might be attributed to reduction in excessive free radicals indirectly by reduced noradrenalin secretion due to dex’s activity at presynaptic alpha-2 adrenoceptor 31. An increase in the concentration of antiapoptotic proteins and reduction in necrotic cell death caused as a result of decreased sympathetic tone by dex are the other possible underlying mechanisms 32.…”

Valuation of three different anaesthetic protocols on complete blood count and biochemical parameters on Wistar rats

“…In the same study by Decartd and colleagues (2007) urea levels were not altered which is in agreement with our findings as far as NCA and VA groups are concerned. The lower values of urea and creatinine observed in IA compared to NCA and VA groups may be attributed to an increase in the urinary output (Gonullu et al, 2014). The latter could be the result of polyuria and hyperglycaemia caused by dexmedetomidine/ketamine combination (Wixson and Smiller, 1997).…”

Renoprotective effects Of Dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats

“…[4,28] Gonullu et al showed that DEX administered before ischemia and after reperfusion histomorphologically reduced renal IR injury, with administration of DEX during reperfusion considered more effective. [29] We speculated that because of the fast onset of effects and rapid clearing of DEX from circulation [30], post-reperfusion treatment with DEX would be more effective in protecting against IR injury than DEX pre-treatment.…”