Syndrome of inappropriate antidiuretic hormone secretion related to Guillain–Barré syndrome after laparoscopic cholecystectomy

Çakırgöz, Mensure Yılmaz; Duran, Esra; Topuz, Cem; Kara, Deniz; Turgut, Namigar; Türkmen, Ülkü Aygen; Turanç, Bülent; Dolap, Mustafa Önder; Hancı, Volkan

doi:10.1016/j.bjane.2013.03.009

Cited by 5 publications

(3 citation statements)

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“…Our data is consistent with this hypothesis, suggesting that several of the previously described cases of hyponatremia in GBS patients could be due to this mechanism. However, due to the lack of essential diagnostic elements in our study, we cannot rule out other possible causes of hyponatremia, such as SIADH and salt wasting syndrome, which have both been reported in association with GBS ( 16 – 18 ).…”

Section: Discussionmentioning

confidence: 84%

“…After a median hospitalization time of 16(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)) days all patients were discharged, 30 (58.8%) of whom had severe residual disability (GDS ≥ 3). Factors associated with significantly reduced odds of severe disability at discharge included higher baseline serum sodium levels [OR (95%CI): 0.77 (0.62-0.96), p = 0.021] and lack of acute axonal injury [OR (95%CI): 0.11 (0.02-0.56), p = 0.008], whereas the presence of motor symptoms was directly associated with this outcome [OR (95%CI): 11.60 (1.28-105.41), p = 0.03].…”

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confidence: 99%

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Sodium Levels Predict Disability at Discharge in Guillain-Barré Syndrome: A Retrospective Cohort Study

et al. 2021

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Guillain-Barré syndrome (GBS) is an inflammatory polyradiculopathy with potentially severe complications. Clinical tools for risk stratification have been developed, but no definitive prognostic biomarker has been reported. Hyponatremia is frequent in GBS patients, but the impact of serum sodium levels on clinical outcomes is still ill-defined. In this retrospective cohort study, we included all adult patients diagnosed with GBS spectrum disorders at our center from January 2010 to July 2020. Disability at discharge was assessed with the GBS Disability Score (GDS), and all clinical and laboratory data was retrieved from medical charts. Thirty (58.8%) of the 51 subjects included in the study were discharged with severe residual disability (GDS ≥ 3). After accounting for relevant confounders, the odds of experiencing severe disability decreased by 27% (p = 0.027) for each unitary increase in serum sodium concentration. Thirteen (25.5%) patients were diagnosed with mild to moderate hyponatremia; the use of intravenous immune globulin (IVIG) independently increased the odds of developing hyponatremia. In conclusion, we found a significant, independent association between baseline serum sodium levels and severe disability at discharge in GBS patients. In our cohort, hyponatremia was more frequently observed after treatment with IVIG, suggesting dilutional pseudohyponatremia as a probable cause.

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Section: Discussionmentioning

confidence: 84%

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confidence: 99%

Sodium Levels Predict Disability at Discharge in Guillain-Barré Syndrome: A Retrospective Cohort Study

et al. 2021

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“…The evidence from the nationwide inpatient sample of 54,778 Guillain-Barré syndrome patients showed that HN was related to severe GBS and was independently associated with adverse discharge disposition (odds ratio: 2.07, 95% confidence interval: 1.91–2.25, P < 0.0001), which suggests that serum sodium should be carefully monitored in GBS patients, especially in patients with a high risk (advanced age, deficiency anemia, alcohol abuse, hypertension, and the utilization of IVIG, all P < 0.0001) (Rumalla et al, 2017). HN has been described mainly as SIADH (Inoue et al, 2010; Monzon Vazquez et al, 2011; Cakirgoz et al, 2014), and the degree of severity of SIADH was associated with the severity of GBS. In addition, it was reported that HN was detected at an average of 8 days after GBS onset (Saifudheen et al, 2011).…”

Section: The Incidence and Clinical Characteristics Of Siadh And Cswsmentioning

confidence: 99%

Inappropriate Antidiuretic Hormone Secretion and Cerebral Salt-Wasting Syndromes in Neurological Patients

Cui

Yang

et al. 2019

Front. Neurosci.

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The differential diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt-wasting syndrome (CSWS) in patients with neurological disorders has been a perplexing clinical controversy. The purpose of this review is to summarize the characteristics and risk factors of patients with different types of neurological disorders complicated by hyponatremia (HN) and review various methods to distinguish SIADH from CSWS. Common neurological disorders with high rates of HN include subarachnoid hemorrhage (SAH), traumatic brain injuries, stroke, cerebral tumors, central nervous system (CNS) infections, and Guillain-Barré syndrome (GBS), which have their own characteristics. Extracellular volume (ECV) status of patients is a key point to differentiate SIADH and CSWS, and a comprehensive assessment of relevant ECV indicators may be useful in differentiating these two syndromes. Besides, instead of monitoring the urinary sodium excretion, more attention should be paid to the total mass balance, including Na+, K+, Cl−, and extracellular fluid. Furthermore, the dynamic detection of fractional excretions (FE) of urate before and after correction of HN and a short-term infusion of isotonic saline solution may be useful in identifying the etiology of HN. As for brain natriuretic peptide (BNP) or N-terminal prohormone of BNP (NT-proBNP), more prospective studies and strong evidence are needed to determine whether there is a pertinent and clear difference between SIADH and CSWS.

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Síndrome de Guillain-Barré e hiponatremia

et al. 2020

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Syndrome of inappropriate antidiuretic hormone secretion related to Guillain–Barré syndrome after laparoscopic cholecystectomy

Cited by 5 publications

References 15 publications

Sodium Levels Predict Disability at Discharge in Guillain-Barré Syndrome: A Retrospective Cohort Study

Sodium Levels Predict Disability at Discharge in Guillain-Barré Syndrome: A Retrospective Cohort Study

Inappropriate Antidiuretic Hormone Secretion and Cerebral Salt-Wasting Syndromes in Neurological Patients

Síndrome de Guillain-Barré e hiponatremia

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