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Cited by 29 publications
(28 citation statements)
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References 27 publications
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“…The antimetastatic activities of AIF against breast cancer cells were reported to be associated with the downregulation of COX‐2 via modulating miR‐124/SPHK1 axis (Han et al, ). The ability of AIF to block cell cycle progression was evidenced in esophageal squamous cell carcinoma, which was achieved by downregulating Nrf2 levels and Nrf2‐driven antioxidant molecule NQO‐1 and HO‐1 (Zhang et al, ), In consistent with the previous observations, we found that AIF was able to block the cell cycle progression in GBM cells, further demonstrating the capability of AIF to impede cell growth.…”
Section: Discussionsupporting
confidence: 91%
“…The antimetastatic activities of AIF against breast cancer cells were reported to be associated with the downregulation of COX‐2 via modulating miR‐124/SPHK1 axis (Han et al, ). The ability of AIF to block cell cycle progression was evidenced in esophageal squamous cell carcinoma, which was achieved by downregulating Nrf2 levels and Nrf2‐driven antioxidant molecule NQO‐1 and HO‐1 (Zhang et al, ), In consistent with the previous observations, we found that AIF was able to block the cell cycle progression in GBM cells, further demonstrating the capability of AIF to impede cell growth.…”
Section: Discussionsupporting
confidence: 91%
“…The inhibitory effect was due to increase expression of miR-101 by suppressing Akt signaling (i.e., decreasing RLIP76 expression and p-Akt/t-Akt ratio) . In addition, AIF was reported to increase radiosensitivity in esophageal squamous cell carcinoma (ESCC) by suppressing the expression of nuclear transcription factor Nrf2 and Nrf2-driven antioxidant molecule NQO-1 and HO-1, aggravating reactive oxygen species (ROS) generation, DNA damage apoptosis, and cell cycle arrest (Zhang et al, 2017a).…”
Section: Phytochemicals In Pre-clinical Trialsmentioning
confidence: 99%
“…Naringin has a protective role in doxorubicin-induced toxicity towards normal tissues without sacrificing its anticancer effect by elevating SOD and total antioxidant capacity against the esophageal cancer stem cell YM1 in xenograft nude mice [217]. Alpinumisoflavone (AIF) could significantly increase the radiosensitivity of esophageal squamous cell carcinoma (ESCC) indicated by enhanced apoptosis, DNA damage, and cell cycle arrest which are mechanically achieved by ROS generation and Nrf2 antioxidant system inhibition both in vitro and in vivo [218]. Wogonin, isolated from the root of Scutellaria baicalensis Georgi, could selectively kill HNC cells by upregulating intracellular ROS with no obvious cytotoxic effect against normal oral keratinocytes, oral fibroblasts, and skin keratinocytes.…”
Section: Oxidative Medicine and Cellular Longevitymentioning
confidence: 99%