pH-Responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy

RGD-modified pH-sensitive liposomes for docetaxel tumor targeting

“…On the other hand, the pH gradient between normal tissues (pH 7.4-7.5) and tumor sites (pH 6.7-6.5) can be used for tumor targeting delivery systems, which are stable in normal tissue while releasing their cargos in acidic environments, guaranteeing reduced toxic side effects and enhanced therapeutic effects [13,14]. In the development of delivery technology, pH-sensitive liposomes Page 4 of 27 A c c e p t e d M a n u s c r i p t have been employed as efficient system for controlled drug release by anchoring molecules responsive to acid pH in target site [15][16][17]. Cholesteryl hemisuccinate (CHEMS), an ester derivative of cholesterol on the 3-hydroxyl group, is a protonic lipid that is frequently used for the construction of pH-responsive delivery systems [18,19].…”

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

“…Materials that need larger pH differences to release their payload or change in conformation could rather serve to enhance cytoplasmic delivery upon endosomal acidification, as this occurs at lower pH values. This could then aid in avoiding further lysosomal degradation or to promote antigen cross-presentation, as previously discussed in section 2.1.1 [95].…”

Inducible release of particulates from liposomes using the mechanosensitive channel of large conductance and l-α-lysophosphatidylcholine

“…PEGylated liposomes coated with polyethylene glycol, commonly referred to as Stealth liposomes, have significantly improved drug delivery properties, including prolonged half-lives and an enhanced ability to evade the immune system (Begum et al 2012). Currently, the most promising liposome preparations are "stimulus-triggered" liposomes (e.g., pH, redox state or temperature triggered liposomes), with pH-triggered liposomes being the most actively researched (Chiang and Lo 2014;Obata et al 2010;Sanchez et al 2011;Yuba et al 2011). pH-triggered liposomes can be inefficient due to the reliance on lipid bilayer destabilization using either a narrow acidic pH range found near tumors or via endosomal uptake, which can result in cargo degradation due to the low pH environment that follows (Ferreira Ddos et al 2013;Straubinger 1993).…”