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Cited by 135 publications
(115 citation statements)
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References 43 publications
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“…Compared to viral delivery systems, both lipo-and polyplexes are generally easy to prepare, not or weakly immunogenic and allow the incorporation of larger DNA chains as there is no intrinsic size limitation as with viral particles [13]. Typically, liposomal systems consist of at least two lipid types: a cationic lipid, which allows them to electrostatically interact with polyanionic DNA and facilitates cellular uptake through endocytosis, and an accompanying matrix lipid with long, unsaturated fatty acid chains, which mostly aid in the endosomal escape of these lipoplexes, resulting in the release of free pDNA in the cytoplasm of the cells [94,95].…”
Section: Mitotic Partitioning Of Inorganic Quantum Dots Gold and Iromentioning
confidence: 99%
“…Compared to viral delivery systems, both lipo-and polyplexes are generally easy to prepare, not or weakly immunogenic and allow the incorporation of larger DNA chains as there is no intrinsic size limitation as with viral particles [13]. Typically, liposomal systems consist of at least two lipid types: a cationic lipid, which allows them to electrostatically interact with polyanionic DNA and facilitates cellular uptake through endocytosis, and an accompanying matrix lipid with long, unsaturated fatty acid chains, which mostly aid in the endosomal escape of these lipoplexes, resulting in the release of free pDNA in the cytoplasm of the cells [94,95].…”
Section: Mitotic Partitioning Of Inorganic Quantum Dots Gold and Iromentioning
confidence: 99%
“…The toxic effect of the liposomes was observed to be slightly higher than that of the MLs and the PpIX-loaded MLs after both 24 and 48 hours of incubation. Soenen et al [27] reported similar results for 3T3 fibroblasts and explained that the slight protective effect was due to stable ML formation.…”
Section: In Vitro Pdt Resultsmentioning
confidence: 65%
“…24 For our in vivo application, however, MSC exposure to cationic bubbles appears transient, as the microbubbles are no longer observed on the engrafted MSCs, and the 24 h experiments confirmed viability of the engrafted cells. Another limitation is the relative heterogeneity of the distribution of the engrafted cells in the relatively large thoracic aorta of the rabbits.…”
Section: Study Limitationsmentioning
confidence: 69%