2014
DOI: 10.1016/j.bbcan.2014.01.008
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Abstract: Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16(INK4a), p14(ARF), NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.

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Cited by 38 publications
(50 citation statements)
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“…Furthermore, our data show that SDC1 is a potent inhibitor of Akt1/2/3 activity. This is particularly interesting in light of the studies showing that the PI3K/ AKT pathway plays a critical role in MM, in which Akt is generally highly activated [68,69] and depends on RTKs, whereas MAPK activation was shown to be independent of receptor activation status [70]. Moreover, Akt1/2/3 is an important factor in the G1/S transition checkpoint.…”
Section: Discussionmentioning
confidence: 95%
“…Furthermore, our data show that SDC1 is a potent inhibitor of Akt1/2/3 activity. This is particularly interesting in light of the studies showing that the PI3K/ AKT pathway plays a critical role in MM, in which Akt is generally highly activated [68,69] and depends on RTKs, whereas MAPK activation was shown to be independent of receptor activation status [70]. Moreover, Akt1/2/3 is an important factor in the G1/S transition checkpoint.…”
Section: Discussionmentioning
confidence: 95%
“…Similarly, somatic BAP1 mutations were reported in 12 out of 53 (23 %) sporadic malignant pleural mesotheliomas [17]. Furthermore, germline BAP1 mutations were reported to cause not only MM, but also uveal melanoma and other cancers [15,16]. We showed here that TU-MM-1 cells have a mutation of the splice site donor in the BAP1 gene and loss of BAP1 protein expression.…”
Section: Discussionmentioning
confidence: 70%
“…Genetic susceptibility is thought to relate to the development of MM. The tumor suppressor gene, BAP1, is located on chromosome 3p21 and encodes BAP1, which is a member of the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes and regulates deubiquitination during DNA damage response and the cell cycle [15]. Testa et al [16] found germline BAP1 mutations in two families with a high incidence of MM, and they also observed somatic truncating BAP1 mutations and aberrant BAP1 expression in 4 out of 18 (22 %) sporadic MM without germline mutations.…”
Section: Discussionmentioning
confidence: 97%
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“…Aberrant signaling cascade has been demonstrated in several cancer types, including mesothelioma [87,88]. Because merlin is a negative regulator of the mTOR pathway, mTOR and merlin loss has become a target of interest in MPM [89].…”
Section: Targeted Therapymentioning
confidence: 99%