Evidence for thyroid endocrine disruption in wild fish in San Francisco Bay, California, USA. Relationships to contaminant exposures

Brar, Navdeep; Waggoner, Claire Michelle; Reyes, Jesus A.; Fairey, Russell; Kelley, Kevin M.

doi:10.1016/j.aquatox.2009.10.023

Cited by 91 publications

(35 citation statements)

References 42 publications

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“…Authors hypothesized that, because of structural similarities, PCBs were able to displace THs from serum binding proteins, causing a decrease in serum levels by biliary clearance. This may explain the correlation found between T3/T4 ratio and PCBs in fish from San Francisco Bay and the Great Lakes (Brar et al, 2010;Gilroy et al, 2012). Ultimately, increases in T4ORD activity, together with parallel decreases in sulfotranferases, enzymes that inactivate and promote TH excretion, would compensate and restore T3 concentration.…”

Section: Effects On Natural Populationsmentioning

confidence: 80%

“…Thyroid disruption by PCBs seems to be mainly triggered by affecting the metabolism of T4, for instance increasing plasma T4 dynamics and glucuronidation. Studies in several teleosts show that exposure to PCB 77, 126 and Aroclor mixture hardly affect deiodination (Adams et al, 2000;Brar et al, 2010;Brown et al, 2004b;Schnitzler et al, 2012Schnitzler et al, , 2011Table 4), likely because the rest of the elements within the HPT axis are able to act in compensation.…”

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 94%

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Deiodinases and thyroid metabolism disruption in teleost fish

Jarque

Piña

2014

Environmental Research

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Section: Effects On Natural Populationsmentioning

confidence: 80%

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 94%

Deiodinases and thyroid metabolism disruption in teleost fish

Jarque

Piña

2014

Environmental Research

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“…They are linked to a number of toxic endpoints that are believed to be independent of the AhR pathway including altered thyroid signaling (e.g. Khan and Hansen, 2003; Brar et al, 2010; Giera et al, 2011) and developmental neurotoxicity (Pessah et al, 2010; Wayman et al, 2012a; Wayman et al, 2012b). Several indicators regarding the neurotoxic potential of PCBs include effects on the central nervous system that are correlated with altered reflexes, cognitive and motor functioning, and hearing impairments in mammalian species (Pessah et al, 2010).…”

Section: 0 Introductionmentioning

confidence: 99%

Structure–activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss)

Fritsch

Pessah

2013

Aquatic Toxicology

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Research addressing the health impacts of polychlorinated biphenyls (PCBs) has primarily focused on the effects of coplanar, or dioxin-like (DL), congeners, which is especially true for research assessing impacts in fish species. Ortho substituted non-coplanar, termed non-dioxin-like (NDL), PCBs have received less attention. In mammals, NDL PCBs enhance the activity of ryanodine receptors (RyR), calcium release channels necessary for engaging excitation-contraction (EC) coupling in striated muscle. We utilized in vitro receptor binding analysis to determine whether NDL PCB congeners detected in aquatic environments alter the activity of RyR isoform 1 (RyR1) found in the skeletal muscle of rainbow trout. Congeners 52, 95, 136, and 149 were the most efficacious leading to an increase in receptor activity that was approximately 250% greater than that found under solvent control conditions. Other environmentally relevant congeners, namely PCB 153, 151 and 101, which all contain two or more chlorines in the ortho-position, enhanced receptor activity by greater than 160% of baseline. The mono-ortho congeners or the non-ortho PCB 77 had negligible impact on the RyR1. When combined, in binary or environmentally relevant mixtures, congeners shown to enhance receptor activity appeared to display additivity and when the active PCB 95 was present with the non-active congener PCB 77 the impact on receptor activity was reduced from 250% to 230%. The important role of the RyR and the demonstrated additive nature of NDL congeners towards altering channel function calls for further investigation into the ecological implications of altered RyR function in fish with high PCB burdens.

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“…An important endocrine system that is targeted by a variety of environmental contaminants is the thyroid hormone system. Field surveys, epidemiological studies as well as laboratory experiments on birds (Brouwer et al, 1998), amphibians (Carr and Patiño, 2011), fish (Brar et al, 2010;Brown et al, 2004) or humans (Patrick, 2009) provide ample evidence that exposure to environmental pollutants can be associated with disruption of thyroid hormone synthesis, metabolism and / or transport and thus can lead to altered thyroid hormone status and thyroid hormone signalling. Thyroiddisrupting effects have been reported for, e.g.…”

Section: Introductionmentioning

confidence: 99%

Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions

et al. 2016

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The vertebrate thyroid system is important for multiple developmental processes, including eye development. Thus, its environmentally induced disruption may impact important fitnessrelated parameters like visual capacities and behaviour. The present study investigated the relation between molecular effects of thyroid disruption and morphological and physiological changes of eye development in zebrafish (Danio rerio). Two test compounds representing different molecular modes of thyroid disruption were used: propylthiouracil (PTU), which is an enzyme-inhibitor of thyroid hormone synthesis, and tetrabromobisphenol A (TBBPA), which interacts with the thyroid hormone receptors. Both chemicals significantly altered transcript levels of thyroid system-related genes (TR, TR, TPO, TSH, DIO1, DIO2 and DIO3) in a compound-specific way. Despite these different molecular response patterns, both treatments resulted in similar pathological alterations of the eyes such as reduced size, RPE cell diameter and pigmentation, which were concentration-dependent. The morphological changes translated into impaired visual performance of the larvae: the optokinetic response was significantly and concentrationdependently decreased in both treatments, together with a significant increase of light preference of PTU-treated larvae. In addition, swimming activity was impacted. This study provides first evidence that different modes of molecular action of the thyroid disruptors can be associated with uniform apical responses. Furthermore, this study is the first to show that pathological eye development, as it can be induced by exposure to thyroid disruptors, indeed translates into impaired visual capacities of zebrafish early life stages. Abstract:The vertebrate thyroid system is important for multiple developmental processes, including eye development. Thus, its environmentally induced disruption may impact important fitnessrelated parameters like visual capacities and behaviour. The present study investigated the relation between molecular effects of thyroid disruption and morphological and physiological changes of eye development in zebrafish (Danio rerio). Two test compounds representing different molecular modes of thyroid disruption were used: propylthiouracil (PTU), which is an enzyme-inhibitor of thyroid hormone synthesis, and tetrabromobisphenol A (TBBPA), which interacts with the thyroid hormone receptors. Both chemicals significantly altered transcript levels of thyroid system-related genes (TR, TR, TPO, TSH, DIO1, DIO2 and DIO3) in a compound-specific way. Despite these different molecular response patterns, both treatments resulted in similar pathological alterations of the eyes such as reduced size, RPE cell diameter and pigmentation, which were concentration-dependent. The morphological changes translated into impaired visual performance of the larvae: the optokinetic response was significantly and concentration-dependently decreased in both treatments, together with a significant increase of light preference of PT...

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Evidence for thyroid endocrine disruption in wild fish in San Francisco Bay, California, USA. Relationships to contaminant exposures

Cited by 91 publications

References 42 publications

Deiodinases and thyroid metabolism disruption in teleost fish

Deiodinases and thyroid metabolism disruption in teleost fish

Structure–activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss)

Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions

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