Maternal transfer of immunity and ontogeny of autologous immunocompetence of fish: A minireview

Mulero, Iván; García‐Ayala, Alfonsa; Meseguer, José; Mulero, Víctoriano

doi:10.1016/j.aquaculture.2007.04.046

Cited by 94 publications

(63 citation statements)

References 49 publications

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“…Morphological studies on the development of the immune systems of fish have shown that immune system mechanisms among teleost are very similar, showing differences only in the development of the adaptive immune system (Mulero et al 2007). In this study, it was possible to establish when the specific immune system became functional from, based on the presence of T4 lymphocytes (CD4 receptors) in the thymus at 7 dah and in the kidney at 13 dah, which indicates the presence of immunological memory.…”

Section: Discussionmentioning

confidence: 95%

Ontogenic development of kidney, thymus and spleen and phenotypic expression of CD3 and CD4 receptors on the lymphocytes of cobia (Rachycentroncanadum )

Klosterhoff

Júnior

Rodrigues

et al. 2015

An. Acad. Bras. Ciênc.

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In the present study was evaluated the ontogenic of immunocompetent organs of cobia up to 53 days after hatching (dah) through histology and immunohistochemistry techniques. The kidney was the first lymphohematopoietic organ to appear, at 1 dah, followed by the spleen at 5 dah and the thymus at 7 dah. The first CD3 receptors on the lymphocytes were observed in 27% of the thymic tissue at 7 dah and in 99% at 53 dah. The phenotypic expression of CD3 receptors was registered in 10% of the kidney at 8 dah and in 32% at 53 dah. CD4 receptors were observed in 5% and 63% of the thymic area at 7 and 53 dah, respectively. In the kidney, T4 lymphocytes were first observed at 13 dah in 9% of the organ and in 28% at 53 dah, defining the functional development of the specific system associated with immunological memory capacity.

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Section: Discussionmentioning

confidence: 95%

Ontogenic development of kidney, thymus and spleen and phenotypic expression of CD3 and CD4 receptors on the lymphocytes of cobia (Rachycentroncanadum )

Klosterhoff

Júnior

Rodrigues

et al. 2015

An. Acad. Bras. Ciênc.

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“…The spleen and kidney are major lymphoid organs in fish (Mulero et al, 2007), and have important functions in implementing immune responses and maintaining a stable internal environment. In this study, spleen and head kidney hsp60 expression was consistently lower than that in liver tissue during heat stress.…”

Section: Discussionmentioning

confidence: 99%

Short Communication Effect of heat stress on heat-shock protein (Hsp60) mRNA expression in rainbow trout Oncorhynchus mykiss

Shi¹,

Liu²,

Zhang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The enhanced expression of heat shock proteins (hsps) in organisms can be detected in response to many kinds of stressor. For fish, high temperature is an important stressor, and hsp expression is associated with differences in environmental temperature. In this study, rainbow trout (Oncorhynchus mykiss) that were accustomed to an aquatic temperature of 18°C were exposed to an elevated temperature (25°C), and hsp60 expression in the gill, liver, spleen, heart, and head kidney was quantified using real-time polymerase chain reaction in unstressed and heat-stressed animals. The fish responded to heat stress in a time-and tissue-specific manner. Cardiac hsp60 mRNA levels were largely unchanged, and the greatest induction of hsp60 in heat-stressed animals was recorded in the liver, suggesting that protein damage and the consequent requirement for the Hsp60 protein are probably greater in hepatic tissue. Therefore, fish must be provided with optimal 5281 Hsp60 expression response to heat stress in trout ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 5280-5286 (2015) temperature conditions in order to realize their potential growth and maximize fish farm profits.

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“…These immune genitors could have transferred transient humoral immune protection against CyHV-3 to their offspring. Teleost fish lay telolecithal eggs in which passive transfer of maternal antibodies occurs [22,23]. Whether embryos from immune versus naive breeders exhibit different sensitivity to CyHV-3 would be interesting to determine in the future, as well as how long this passive protection lasts.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and permissivity of Cyprinus carpio to cyprinid herpesvirus 3 during the early stages of its development: importance of the epidermal mucus as an innate immune barrier

Ronsmans

Boutier

Rakus

et al. 2014

Vet Res

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Cyprinid herpesvirus 3 (CyHV-3) causes a lethal disease in common and koi carp (Cyprinus carpio). The present study investigated the ability of CyHV-3 to infect common carp during the early stages of its development (from embryos to fingerlings) after inoculation by immersion in water containing the virus. Fish were inoculated at different times after hatching with a pathogenic recombinant CyHV-3 strain expressing luciferase. The sensitivity and permissivity of carp to CyHV-3 were investigated using in vivo bioluminescence imaging. The susceptibility of carp to CyHV-3 disease was investigated by measuring the survival rate. Carp were sensitive and permissive to CyHV-3 infection and susceptible to CyHV-3 disease at all stages of development, but the sensitivity of the two early developmental stages (embryo and larval stages) was limited compared to later stages. The lower sensitivity observed for the early developmental stages was due to stronger inhibition of viral entry into the host by epidermal mucus. In addition, independent of the developmental stage at which inoculation was performed, the localization of light emission suggested that the skin is the portal of CyHV-3 entry. Taken together, the results of the present study demonstrate that carp are sensitive and permissive to CyHV-3 at all stages of development and confirm that the skin is the major portal of entry after inoculation by immersion in infectious water. The results also stress the role of epidermal mucus as an innate immune barrier against pathogens even and especially at the early stages of development.

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Maternal transfer of immunity and ontogeny of autologous immunocompetence of fish: A minireview

Cited by 94 publications

References 49 publications

Ontogenic development of kidney, thymus and spleen and phenotypic expression of CD3 and CD4 receptors on the lymphocytes of cobia (Rachycentroncanadum )

Ontogenic development of kidney, thymus and spleen and phenotypic expression of CD3 and CD4 receptors on the lymphocytes of cobia (Rachycentroncanadum )

Short Communication Effect of heat stress on heat-shock protein (Hsp60) mRNA expression in rainbow trout Oncorhynchus mykiss

Sensitivity and permissivity of Cyprinus carpio to cyprinid herpesvirus 3 during the early stages of its development: importance of the epidermal mucus as an innate immune barrier

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