2015
DOI: 10.1016/j.apsb.2015.05.005
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Abstract: Licorice is a common herb which has been used in traditional Chinese medicine for centuries. More than 20 triterpenoids and nearly 300 flavonoids have been isolated from licorice. Recent studies have shown that these metabolites possess many pharmacological activities, such as antiviral, antimicrobial, anti-inflammatory, antitumor and other activities. This paper provides a summary of the antiviral and antimicrobial activities of licorice. The active components and the possible mechanisms for these activities … Show more

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Cited by 399 publications
(279 citation statements)
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“…NF-κBp65 is predominant in the apoptotic regulation process by regulating the expression of downstream Bcl-2 genes. Bax participates in apoptotic responses via intrinsic mitochondrial-dependent signaling by inducing the release of cytochrome c (23,(43)(44)(45). Another cell death protease is caspase-3, which serves a role in cell apoptosis.…”
Section: Discussionmentioning
confidence: 99%
“…NF-κBp65 is predominant in the apoptotic regulation process by regulating the expression of downstream Bcl-2 genes. Bax participates in apoptotic responses via intrinsic mitochondrial-dependent signaling by inducing the release of cytochrome c (23,(43)(44)(45). Another cell death protease is caspase-3, which serves a role in cell apoptosis.…”
Section: Discussionmentioning
confidence: 99%
“…This plant has been traditionally used as a medicinal agent due to its antibacterial, anti-viral, anti-inflammatory and calming effects [1720]. Glycyrrhetinic acid is a major component in licorice extract.…”
Section: Introductionmentioning
confidence: 99%
“…Beclin 1 is an autophagy activator that was shown to inhibit the replication of HSV-1 27. Laconi et al also showed that when glycyrrhizin was added to HeLa cells concurrently with HSV-1, glycyrrhizin had a strong anti-HSV-1 effect, whereas rapamycin did not.…”
Section: Discussionmentioning
confidence: 99%