First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid

Ighodaro, Osasenaga Macdonald; Akinloye, Oluyemi

doi:10.1016/j.ajme.2017.09.001

Cited by 2,167 publications

(1,360 citation statements)

References 48 publications

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“…Antioxidant enzymes are vital substances in protecting the cell from oxidative damage and maintaining the cellular redox homeostasis. SOD catalyzes the disproportionation of superoxide anion to form hydrogen peroxide and oxygen molecules, and CAT decomposes hydrogen peroxide into water and oxygen (Ighodaro & Akinloye, ). As shown in Figure , both the activities of SOD and CAT enzymes decreased in PA‐treated cells, whereas the treatments of the cells with VA (10, 25 μM) indeed returned this change.…”

Section: Resultsmentioning

confidence: 99%

Vanillic acid alleviates palmitic acid‐induced oxidative stress in human umbilical vein endothelial cells via Adenosine Monophosphate‐Activated Protein Kinase signaling pathway

Duan

Han

et al. 2019

J Food Biochem

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Vanillic acid (VA), one of the phenolic acids metabolized by anthocyanidins, can modulate vascular reactivity by reducing the superoxide. We investigated that VA alleviated fatty acid‐induced oxidative stress and clarified its potential mechanisms in human umbilical vein endothelial cells (HUVECs). Our results showed that VA reduced the production of reactive oxygen species and malondialdehyde levels. It also restored mitochondrial membrane potential and enhanced the activities of antioxidant enzymes. In addition, VA promoted the expression of p‐Nrf2 and HO‐1 through LKB1/AMPK signaling pathway, as well as the level of SIRT1 and PGC‐1α. Moreover, compound C reduced the effect of VA on the enhancement of p‐Nrf2 and HO‐1. These results indicated that AMPK was an important target molecule of VA in the process of alleviating oxidative stress in HUVECs, providing a new potential evidence for vascular protection of anthocyanin in vitro. Practical applications As a phenolic derivative and phase II metabolite of anthocyanins in vivo, VA can be found in various edible plants and fruits. This study revealed that VA improved oxidative stress in endothelial cells stimulated by palmitic acid by activating AMPK and its downstream proteins. VA could be a potential functional material for the protection of diabetic vascular complications.

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Section: Resultsmentioning

confidence: 99%

Vanillic acid alleviates palmitic acid‐induced oxidative stress in human umbilical vein endothelial cells via Adenosine Monophosphate‐Activated Protein Kinase signaling pathway

Duan

Han

et al. 2019

J Food Biochem

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“…These results suggest that in the presence of O 2 .− both the frameworks are capable of oxidising Mn +2 to Mn +3 . It should be mentioned that the oxidative stress generated inside living cells are normally regulated by certain enzymes to keep cells disease free . The superoxide dismutase is such an enzyme that catalyses conversion of O 2 .− to H 2 O 2 .…”

Section: Resultsmentioning

confidence: 99%

Manganese‐Coordinated Tyrosine Bio Materials for the Sensing of Reactive Oxygen Species

Jena

2019

ChemistrySelect

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Design of biosensor materials for the recognition of reactive oxygen species (ROS) inside living cells is necessary for the early diagnosis of cancer and other diseases induced by ROS. Here, the B3LYP−D3 dispersion‐corrected and Mo6 hybrid density functional theoretical methods and a polarized continuum model to account for the aqueous medium are used to propose models of manganese (Mn+2)‐coordinated tyrosine (Tyr) nano rods and porous bio materials to detect various ROS, such as .OH, .OOH, H2O2, .NO, ONOO−, and O2.−. It is found that the nano rods and porous polymers may sense the presence of different ROS by utilizing their edges and pores respectively. It is further revealed that due to stable binding and adsorption energies, entrapment of different ROS by the porous polymers would be sustained for longer time compared to the nano rods. However, the edges of nano rods are reactive and may initiate oxidation reactions by converting Mn+2 to Mn+3. It is thus expected that these bio materials would act as excellent ROS sensors.

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“…There are various enzymatic as well as nonenzymatic systems for removal and regulation of RONS. Among them manganese superoxide dismutase (MnSOD or SOD2), glutathione peroxidase (GPX), and catalase (CAT) are well‐known enzymes involved in this process …”

Section: Introductionmentioning

confidence: 99%

The effects of the genetic polymorphisms of antioxidant enzymes on susceptibility to papillary thyroid carcinoma

et al. 2020

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Several lines of evidences have indicated that inflammation play an important role in the carcinogenesis. During the inflammatory processes, free radical species are produced from oxidative stress. In normal conditions, enzymatic and nonenzymatic antioxidants remove these products. Manganese superoxide dismutase (MnSOD), glutathione peroxidase‐1 (GPx‐1), and catalase (CAT) are three important enzymes. Therefore, this study aimed to evaluate the effects of MnSOD (SOD2), GPX‐1, and CAT genetic polymorphisms on papillary thyroid carcinoma (PTC) susceptibility. A total of 134 patients with PTC and 151 healthy controls were recruited to participate in this study. All samples were genotyped for SOD2 rs4880, GPX1 1050450, and CAT rs7943316 polymorphisms by polymerase chain reaction‐restriction fragment length polymorphism method. The frequencies of the rs1050450, rs4880, and rs7943316 alleles and genotypes were not different between PTC patients and controls. However, the TC genotype of SOD2 rs4880 polymorphism was significantly higher in males compared to that in females in PTC patients (odds ratio [OR], 3.9 [95% CI, 1.5–11], p = .007). The rs4880 polymorphism was also associated with higher stages (III‐IV) of PTC in dominant model. No significant correlation was found between GPX1‐rs1050450 and CAT‐rs7943316 polymorphisms and demographic, clinical, and pathological features of the disease. The SOD2 rs4880CT genotype was more frequent in males with PTC and patients with higher stages (III–IV) of disease (OR, 2.9 [95% CI, 1.1–7.7], p = .04). However, no significant association was found between GPX1‐rs1050450 and CAT‐rs7943316 variants and PTC or its demographic, clinical, and pathological features.

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First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid

Abstract: View related articles View Crossmark data Citing articles: 365 View citing articles First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid

Cited by 2,167 publications

References 48 publications

Vanillic acid alleviates palmitic acid‐induced oxidative stress in human umbilical vein endothelial cells via Adenosine Monophosphate‐Activated Protein Kinase signaling pathway

Vanillic acid alleviates palmitic acid‐induced oxidative stress in human umbilical vein endothelial cells via Adenosine Monophosphate‐Activated Protein Kinase signaling pathway

Manganese‐Coordinated Tyrosine Bio Materials for the Sensing of Reactive Oxygen Species

The effects of the genetic polymorphisms of antioxidant enzymes on susceptibility to papillary thyroid carcinoma

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