Regressing eruptive disseminated pigmented Spitz (Reed) nevi in a young adult

Lozano-Masdemont, Belén; Pérez-Tato, Berta; Zamora-Martínez, Elena; Rodríguez‐Lomba, Enrique

doi:10.1016/j.abd.2020.11.009

Cited by 2 publications

(2 citation statements)

References 8 publications

(28 reference statements)

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“…57 In several cases, EDSN spontaneously regressed. 3,4,7,31 Lymphocyte-mediated regression (different to involution due to senescence) is not an uncommon phenomenon in Spitz nevi, 59 although it usually takes months or years, [60][61][62] and it is not necessarily complete. It happens in some degree in up to 79% of cases of Spitz nevus.…”

Section: Case Reportmentioning

confidence: 99%

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Genetic Studies on a Case of Eruptive Disseminated Spitz Nevus and Review of Other 33 Cases

Fernández-Flores

Cassarino

2022

The American Journal of Dermatopathology

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Eruptive disseminated Spitz nevus is an uncommon presentation of Spitz nevi. Only a few tens of cases have been published and only 6 of them have genetic studies. We present an additional case of a 29-year-old woman with dozens of Spitz nevi which had appeared since she was aged 10 years. The nevi were located on arms, inner thighs, legs, and buttocks. Nine of them were biopsied. Four presented severe atypia. Immunohistochemistry was performed on 5 of the biopsied specimens and was negative for PRAME, ROS-1, PDL-1, pan-TRK, and ALK. Molecular studies on the largest lesion demonstrated no NTRK1, NTRK2, or NTRK3 fusions. FISH study for PTEN showed no alteration in that same lesion. Next-generation sequencing was also negative for any detectable mutations in numerous genes analyzed. In conclusion, it seems reasonable to be cautious when evaluating atypia, even if severe, in cases of eruptive disseminated Spitz nevus.

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Section: Case Reportmentioning

confidence: 99%

“…Eruptive disseminated Spitz nevus (EDSN) is an uncommon presentation of Spitz nevi with only 33 cases described in the literature 1–32 (Table 1). Most patients were otherwise healthy.…”

Section: Introductionmentioning

confidence: 99%

Genetic Studies on a Case of Eruptive Disseminated Spitz Nevus and Review of Other 33 Cases

Fernández-Flores

Cassarino

2022

The American Journal of Dermatopathology

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Diagnostic Imaging of Agminated Blue Lesions and Blue Lesions with Satellitosis: Case Series with a Concise Review of the Current Literature

Cantisani,

Paolino,

Di Guardo

et al. 2024

JCM

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Background: Agmination and/or satellitosis in pigmented blue lesions is a phenomenon rarely mentioned in the literature and not well known. This phenomenon can be expressed by several benign and malignant pigmented blue lesions, such as blue nevi, Spitz nevi, melanocytoma and melanoma. On this spectrum, dermoscopy, reflectance confocal microscopy (RCM) and dynamic Optical coherence tomography (D-OCT) represent non-invasive imaging technologies, which may help clinicians in the diagnosis of melanoma and non-melanoma skin cancers in daily clinical practice. Methods: Currently, in the literature there is a lack of new data about agminated blue lesions and blues lesions with satellitosis, as well as the lack of a recent and updated review of the literature about this topic. Therefore, considering that clinicians must be confident with the diagnosis of these rare skin lesions, we decided to carry out this work. Results: In this paper, four new cases of agminated pigmented cutaneous lesions were described. Moreover, a review of the current literature on this topic was performed. Conclusions: A clinical–pathological correlation is often needed to reach a correct diagnosis; currently, dermoscopy and non-invasive diagnostic techniques, such as reflectance confocal microscopy and optical coherence tomography, due to the depth of these skin lesions in the dermis, can only make a partial and limited contribution.

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Regressing eruptive disseminated pigmented Spitz (Reed) nevi in a young adult

Cited by 2 publications

References 8 publications

Genetic Studies on a Case of Eruptive Disseminated Spitz Nevus and Review of Other 33 Cases

Genetic Studies on a Case of Eruptive Disseminated Spitz Nevus and Review of Other 33 Cases

Diagnostic Imaging of Agminated Blue Lesions and Blue Lesions with Satellitosis: Case Series with a Concise Review of the Current Literature

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