Rosacea associated with increased risk of generalized anxiety disorder: a case-control study of prevalence and risk of anxiety in patients with rosacea

Uysal, Pınar Incel; Akdoğan, Neslihan; Hayran, Yıldız; Öktem, Ayşe; Yalçın, Başak

doi:10.1016/j.abd.2019.03.002

Cited by 16 publications

(20 citation statements)

References 18 publications

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“…A new concept of HB in rosacea patients was recently proposed. This concept indicates that for HB rosacea patients, at least three of four domains are positive (DLQI, WTP, TTO, and lifestyle) (27,29). Based on this definition, we identified 17.8% HB rosacea patients in the present study, a finding which is similar to that of a previous study (27).…”

Section: Discussionsupporting

confidence: 85%

Prevalence and Risk Factors of Anxiety and Depression in Rosacea Patients: A Cross-Sectional Study in China

et al. 2021

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Rosacea is a chronic inflammatory skin disease characterized by facial redness and bothersome symptoms. It can exert significant psychological effects and impair the quality of life of patients. To investigate the prevalence and risk predictors of anxiety and depression in rosacea patients, we conducted a cross-sectional study in an outpatient setting. Consecutive patients completed a questionnaire, which included questions on sociodemographic information and severity of signs and symptoms; they also completed the Patient Health Questionnaire and the Generalized Anxiety Disorder scale. Disease burden was assessed using Dermatology Life Quality Index (DLQI), Willing-to-Pay, and Time trade-off. Multivariate analysis was conducted to determine the risk factors for anxiety and depression. A total of 774 patients completed the survey. The prevalence of anxiety was 53.9% (95% CI: 50.4–57.4%) and that of depression was 58.1% (95% CI: 54.7–61.6%). The factors associated with anxiety were age, gender, the need to make appearances at work, severity of self-reported symptoms, the number of rosacea signs and adaptive behaviors, and disease burden. Depression was associated with younger age, more severe self-reported symptoms, more adaptive behaviors, and higher disease burden. After adjusting for demographics, the risk of anxiety or depression increased in young patients who had severe self-reported symptoms, high DLQI scores, and many adaptive behaviors. Taken together, there is a high prevalence of anxiety and depression among Chinese rosacea patients. Younger rosacea patients who have more severe self-reported symptoms and higher disease burden are prone to anxiety and depression.

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Section: Discussionsupporting

confidence: 85%

Prevalence and Risk Factors of Anxiety and Depression in Rosacea Patients: A Cross-Sectional Study in China

et al. 2021

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“…The pathogenesis and related mechanisms need further exploration to develop more etiological treatment modalities. The waxing and waning course of rosacea may disturb patients to a large extent, and rosacea is also related to many psychiatric disorders, such as anxiety and depression [ 91 ]. Dermatologists should focus on patient experience and patient education, and they should schedule regular follow-ups if necessary.…”

Section: Discussionmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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Rosacea is a chronic and inflammatory skin disease characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. In 2017, a phenotype-based approach for diagnosis and classification was recommended. With the update of the diagnosis and classification of rosacea, treatment options for patients with rosacea have attracted the attention of dermatologists. Here, we summarize the latest advances in rosacea treatment, including skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosacea, treatments for systemic comorbidities, and combination therapies. The impact of the phenotype-based approach on rosacea treatment and future directions are also discussed.

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“…Then, 29 articles were excluded for the following reasons: being unrelated to the topic (n = 11), full text not found (n = 2), being a conference summary (n = 7), not meeting the inclusion criteria (n = 6), and potentially coming from the same database (n = 3). Finally, we included 12 case‐control studies for the meta analysis 5,11,12,15,18‐25 . A flow diagram of the literature search is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, we included 12 case-control studies for the meta analysis. 5,11,12,15,[18][19][20][21][22][23][24][25] A flow diagram of the literature search is presented in Figure 1. Table 1.…”

Section: Literature Searchmentioning

confidence: 99%

“…In the general analysis for all included articles, tobacco consumption did not appear to increase the risk of rosacea (OR = 1.22, 95% CI 0.98-1.52, P = .082; I 2 = 90.0%, P = .000) (Figure 2A). However, in a subtype analysis (involving five articles), 5,11,12,15,23 we found a decreased risk of rosacea in current smokers (OR = 0.54, 95% CI 0.41-0.72, P = .000; I 2 = 39.9%, P = .155) ( Figure 2B) and increased risk in ex-smokers (OR = 1.84, 95% CI 1.38-2.47, P = .000; I 2 = 39.9%, P = .155)( Figure 2C) (Supplement Table 1). Considering the high weightage of Spoendlin's study, we performed subtype analysis again after removing that article.…”

Section: The Risk Of Rosacea In Smokingmentioning

confidence: 99%

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Association between rosacea and smoking: A systematic review and meta‐analysis

Yuan

Yin

2021

Dermatologic Therapy

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Rosacea is a chronic inflammatory disease of the centrofacial region. However, the association between rosacea and smoking remains controversial. To evaluate the association between rosacea and smoking, we performed a systematic review and meta-analysis. A comprehensive systematic search of literature published before October 15, 2020 on online databases (including Web of Science, PubMed, Cochrane Library, and Embase) was performed. The pooled odds ratios (ORs) were calculated. 12 articles were included, covering 80 156 controls and 54 132 patients with rosacea. Tobacco consumption was not found to increase the risk of rosacea. However, using subtype analysis (involving 5 articles), we found there was a decreased risk of rosacea in current smokers but an increased risk in ex-smokers. In addition, smoking appears to increase the risk of papulopustular rosacea and phymatous rosacea. Analysis of all included studies also showed that ex-smoking was associated with an increased risk, while current smoking was associated with a reduced risk of rosacea. In order to prevent many diseases, including rosacea, the public should be encouraged to avoid smoking.

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Rosacea associated with increased risk of generalized anxiety disorder: a case-control study of prevalence and risk of anxiety in patients with rosacea

Cited by 16 publications

References 18 publications

Prevalence and Risk Factors of Anxiety and Depression in Rosacea Patients: A Cross-Sectional Study in China

Prevalence and Risk Factors of Anxiety and Depression in Rosacea Patients: A Cross-Sectional Study in China

Rosacea Treatment: Review and Update

Association between rosacea and smoking: A systematic review and meta‐analysis

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