Modelling food digestion

Cleary, Paul W.; Sinnott, Matthew D.; Hari, Bostjan; Bakalis, Serafim; Harrison, Simon

doi:10.1016/b978-1-78242-284-6.00010-6

Cited by 13 publications

(11 citation statements)

References 90 publications

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“…Recently, a promising smooth particle hydrodynamics (SPH) computational model developed originally for the intestine was applied also to a stomach‐like geometry examining gastric motility and emptying. These computational models revealed important patterns in gastric flow. For low viscosity dominant retrograde jets in the antrum, circulatory flow between the ACWs, and a so‐called “stomach road,” along which gastric emptying occurs predominantly, were reported.…”

Section: Mathematical and Computational Modelingmentioning

confidence: 99%

Mechanics of the stomach: A review of an emerging field of biomechanics

et al. 2019

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Mathematical and computational modeling of the stomach is an emerging field of biomechanics where several complex phenomena, such as gastric electrophysiology, fluid mechanics of the digesta, and solid mechanics of the gastric wall, need to be addressed. Developing a comprehensive multiphysics model of the stomach that allows studying the interactions between these phenomena remains one of the greatest challenges in biomechanics. A coupled multiphysics model of the human stomach would enable detailed in‐silico studies of the digestion of food in the stomach in health and disease. Moreover, it has the potential to open up unprecedented opportunities in numerous fields such as computer‐aided medicine and food design. This review article summarizes our current understanding of the mechanics of the human stomach and delineates the challenges in mathematical and computational modeling which remain to be addressed in this emerging area.

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Section: Mathematical and Computational Modelingmentioning

confidence: 99%

Mechanics of the stomach: A review of an emerging field of biomechanics

et al. 2019

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“…Computational models of peristalsis in the presence of suspended solids were proposed through the use of an immersed boundary method imposing prescribed displacements to the elastic boundaries (Fauci, 1992). Immersed boundary 980 methods and particle methods have also recently been used to describe bolus transport in the gastrointestinal tract, as reviewed by (Cleary et al, 2015). A model of esophageal motion through circular and longitudinal muscle contractions was proposed by Kou et al (Kou et al, 2015).…”

Section: In Vitro and In Silico Models Of The Esophageal Phase Of Swamentioning

confidence: 99%

A review of the approaches to predict the ease of swallowing and post-swallow residues

Marconati¹,

Engmann²,

Burbidge³

et al. 2019

Trends in Food Science & Technology

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“…[12,13] and the reviews in Refs. [11,14,15]. In particular, some authors have formulated anatomically accurate 3D computational models of food breakdown in the mouth [11] and of gastric digestion [11,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Mesoscale modelling of polymer aggregate digestion

Novev

Doostmohammadi

Zöttl

et al. 2020

Current Research in Food Science

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We use mesoscale simulations to gain insight into the digestion of biopolymers by studying the breakup dynamics of polymer aggregates (boluses) bound by physical cross-links. We investigate aggregate evolution, establishing that the linking bead fraction and the interaction energy are the main parameters controlling stability with respect to diffusion. We show via a simplified model that chemical breakdown of the constituent molecules causes aggregates that would otherwise be stable to disperse. We further investigate breakdown of biopolymer aggregates in the presence of fluid flow. Shear flow in the absence of chemical breakdown induces three different regimes depending on the flow Weissenberg number (W i). i) At W i 1, shear flow has a negligible effect on the aggregates. ii) At W i ∼ 1, the aggregates behave approximately as solid bodies and move and rotate with the flow. iii) At W i 1, the energy input due to shear overcomes the attractive cross-linking interactions and the boluses are broken up. Finally, we study bolus evolution under the combined action of shear flow and chemical breakdown, demonstrating a synergistic effect between the two at high reaction rates. arXiv:1911.07510v1 [cond-mat.soft]

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Modelling food digestion

Cited by 13 publications

References 90 publications

Mechanics of the stomach: A review of an emerging field of biomechanics

Mechanics of the stomach: A review of an emerging field of biomechanics

A review of the approaches to predict the ease of swallowing and post-swallow residues

Mesoscale modelling of polymer aggregate digestion

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