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Cited by 369 publications
(268 citation statements)
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“…Moreover, these drugs are also good substrates for both hepatic and gut CYP3A4 enzyme which further result in their high metabolism and low oral bioavailability (Alsenz et al, 1998;Kim et al, 1998;Polli et al, 1999;Lee et al, 2003). P-gp is a 170kDa protein, member of ATP binding cassette (ABC) transporter family (Germann, 1996). P-gp is ubiquitously expressed on human tissues such as intestinal mucosa, brain capillary endothelial cells, biliary canaliculus, and kidney tubules (Thiebaut et al, 1987).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, these drugs are also good substrates for both hepatic and gut CYP3A4 enzyme which further result in their high metabolism and low oral bioavailability (Alsenz et al, 1998;Kim et al, 1998;Polli et al, 1999;Lee et al, 2003). P-gp is a 170kDa protein, member of ATP binding cassette (ABC) transporter family (Germann, 1996). P-gp is ubiquitously expressed on human tissues such as intestinal mucosa, brain capillary endothelial cells, biliary canaliculus, and kidney tubules (Thiebaut et al, 1987).…”
Section: Introductionmentioning
confidence: 99%
“…However, their clinical usefulness is limited by the occurrence of multidrug resistance (MDR) associated with the presence of membrane transporters (e.g. P-glycoprotein, MRP1), belonging to the ATP-binding cassette protein family (Gottesman and Pastan, 1993;Germann, 1996;Marie et al, 1996;Borst et al, 2000). These transporters are responsible for the active ATP-dependent efflux of drugs out of resistant cells resulting in the decreased intracellular accumulation insufficient to inhibit resistant cell proliferation (Zaman et al, 1994;Paul et al, 1996).…”
mentioning
confidence: 99%
“…P-glycoprotein (P-gp), an energy-dependent drug efflux pump shown to confer multidrug resistance (MDR) Pastan, 1988, 1993;Lehnert, 1996;Germann, 1996) 2. alterations in β-tubulin isotypes (Haber et al, 1995;Ranganathan et al, 1988Kavallaris et al, 1997 3. mutations in tubulins (Cabral et al, 1981;Schibler and Cabral, 1986;Giannakakou et al, 1997) 4. up-regulation of caveolin-1 (Yang et al, 1998).…”
mentioning
confidence: 99%