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Cited by 80 publications
(25 citation statements)
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“…CS, chitosan. agreement with previous work that showed that colloidal particles are taken up and transported across the corneal epithelial cells (8). In order to elucidate whether the particles are simply able to stick to the ocular mucosa or further able to enter the epithelia, we examined cross sections of the corneal and conjunctival epithelia by confocal laser scanning microscopy.…”
Section: In Vivo Study: Quantitative and Qualitative Evaluation Of Thmentioning
confidence: 60%
See 2 more Smart Citations
“…CS, chitosan. agreement with previous work that showed that colloidal particles are taken up and transported across the corneal epithelial cells (8). In order to elucidate whether the particles are simply able to stick to the ocular mucosa or further able to enter the epithelia, we examined cross sections of the corneal and conjunctival epithelia by confocal laser scanning microscopy.…”
Section: In Vivo Study: Quantitative and Qualitative Evaluation Of Thmentioning
confidence: 60%
“…The images suggest that CS nanoparticles are preferably transported by a paracellular mechanism, although the round spots visible inside the cells also support their transcellular transport. This behavior is slighly different from that of other types of nanoparticles, such as poly(alkylcyanoacrylate) (28) and PECL nanoparticles (8), the transport of which was found to occur by a transcellular pathway. Nevertheless, the paracellular transport of CS nanoparticles could be better explained by the intrinsic properties of CS molecules.…”
Section: In Vivo Study: Quantitative and Qualitative Evaluation Of Thmentioning
confidence: 85%
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“…Confocal images of both, the cornea and the conjunctiva, show that the instilled nanoparticles (HA-fl:CSO and HA-fl:CS, with a mass ratio of 1:2) were located inside the corneal and conjunctival cells, suggesting that they penetrate the epithelia by a transcellular pathway. This mechanism, which has also been reported for other nanosystems, 14,15 could be reinforced by the known ability of HA to interact with the CD44 receptor expressed on the ocular surface. 18,37 In fact, the fluorescence observed in the cornea exposed to HA-fl solution suggest that the polymer was also internalized into the cells.…”
Section: Bioadhesive Nanoparticles For Ocular Gene Therapy M De La Fumentioning
confidence: 87%
“…11,12 In the specific area of ocular gene therapy, nanoparticles are particularly attractive due to their known ability to intimately interact with the ocular surface. 13 More specifically, our group has shown that polymeric nanoparticles are capable of adhering to the ocular surface and penetrate through the corneal and conjunctival epithelia, 14,15 thereby achieving a targeted drug delivery after topical administration. 16 However, despite this well-known ocular behaviour of nanoparticles and their potential for ocular drug delivery, their application for ocular gene therapy remains to be explored.…”
Section: Introductionmentioning
confidence: 99%