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Cited by 91 publications
(42 citation statements)
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“…Notably, M2 is almost significantly correlated with all parameters related to tumor invasiveness such as preoperative CEA level, lymphatic metastasis, tumor differentiation and liver metastatic ability. CEA is a common tumor marker, and is closely related to liver metastasis of colorectal cancer (Leskoviku et al, 1992;Thomas et al, 1995;Hatate et al, 2008). Aarons et al (2007) find that, CEA can act on the receptor in macrophages, and stimulate macrophages to secrete cytokines and endothelial cell adhesion molecules, thus promoting the liver metastasis in colorectal cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Notably, M2 is almost significantly correlated with all parameters related to tumor invasiveness such as preoperative CEA level, lymphatic metastasis, tumor differentiation and liver metastatic ability. CEA is a common tumor marker, and is closely related to liver metastasis of colorectal cancer (Leskoviku et al, 1992;Thomas et al, 1995;Hatate et al, 2008). Aarons et al (2007) find that, CEA can act on the receptor in macrophages, and stimulate macrophages to secrete cytokines and endothelial cell adhesion molecules, thus promoting the liver metastasis in colorectal cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Because the precise involvement of this tumour marker in the development of liver metastases cannot be analysed in humans, many studies have been conducted using animal models to try to demonstrate a connection between cause and effect. Most of the studies designed to address this question were based on the hypothesis that the adhesive properties of CEA might facilitate the development of liver metastases from colorectal cancer (Hostetter et al, 1990;Jessup et al, 1993a;Tibbetts et al, 1993;Thomas et al, 1995;Landuzzi et al, 1996). Recently, some authors suggested that CEA could enhance liver metastases via induction of cytokines in Kupffer cells (Gangopadhyay et al, 1996;Edmiston et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…The question addressed in the present study was to determine whether these adhesive properties facilitate the development of liver metastases from colorectal cancer. Up to now, the involvement of CEA in the development of liver metastases from colorectal cancers has been addressed in two different ways: (i) comparison of the metastatic potential of different human colon carcinoma cell lines or CEA-transfected cells in association with CEA membrane expression (Tibbetts et al, 1993;Thomas et al, 1995;Landuzzi et al, 1996); (ii) analysis of the effect of circulating CEA on the development of liver metastases from different human colon carcinoma cells (Hostetter et al, 1990;Jessup et al, 1993a). This second approach is particularly interesting since one can imagine different strategies for modifying circulating CEA levels such as its capture with anti-CEA monoclonal antibodies (mAb).…”
mentioning
confidence: 99%
“…Expression of CEA has been clearly correlated to generation of liver metastases in experiments transfecting CEA to CRC cell lines or administering CEA in animal models previous to CRC cell injection (Thomas et al, 1995). A recent study demonstrated that CEA was responsible for modifying the hepatic environment, making it more conducive for colon cancer cell survival (Gangopadhyay, Lazure, & Thomas, 1998).…”
Section: Metastasis-associated Factors Facilitating the Progression Omentioning
confidence: 99%