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Cited by 78 publications
(8 citation statements)
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“…Until recently, the majority of the studies on BPA focused on these nuclear mechanisms of estrogen responses that rely on ER action into the nucleus. On these bases, BPA has been and is still defined as a “weak estrogen.” 41 However, estrogens, as well as other steroid hormones, can also induce rapid (seconds to minutes) extranuclear responses based on ER localized at the plasma membrane. A small pool of ERα and ERβ is palmitoylated and localized at the plasma membrane in association with caveolin 1.…”
Section: Mechanisms Leading To Activation Of Nuclear Receptorsmentioning
confidence: 99%
“…Until recently, the majority of the studies on BPA focused on these nuclear mechanisms of estrogen responses that rely on ER action into the nucleus. On these bases, BPA has been and is still defined as a “weak estrogen.” 41 However, estrogens, as well as other steroid hormones, can also induce rapid (seconds to minutes) extranuclear responses based on ER localized at the plasma membrane. A small pool of ERα and ERβ is palmitoylated and localized at the plasma membrane in association with caveolin 1.…”
Section: Mechanisms Leading To Activation Of Nuclear Receptorsmentioning
confidence: 99%
“…In the past, the basis for calling an estrogen “weak” or “strong” has been entirely dependent upon the nuclear transcription signalling mechanism [320]. It is now becoming clear that “weak” activity via one pathway does not necessarily predict the potency of a hormone or mimetic acting via another signalling pathway.…”
Section: Mechanistic Considerationsmentioning
confidence: 99%
“…These compounds alter many aspects of the endocrine-metabolic homeostasis because of their ability to mimic and/or antagonize the biological activity of endogenous hormones (Pande et al, 2019), likely binding to specific receptors. Although the main EDC effect is on the reproductive system (McLachlan et al, 1984), growing evidence shows that some compounds can also impair body weight regulation by affecting metabolism (Migliaccio et al, 1996) and functional activity of adipocytes, often leading to obesity. These EDCs are defined as “obesogens” (Grun and Blumberg, 2006).…”
Section: Epigenetics Modifications Upon Early Exposure To Chemicals Tmentioning
confidence: 99%