Low hepatic 7-ethoxyresorufin-O-deethylase (EROD) activity and minor alterations in retinoid and thyroid hormone levels in flounder (Platichthys flesus) exposed to the polychlorinated biphenyl (PCB) mixture, Clophen A50

Besselink, H.; Beusekom, S. van; Roex, E.; Vethaak, A.D.; Koeman, J.H.; Brouwer, Abraham

doi:10.1016/0269-7491(95)00116-6

Cited by 31 publications

(16 citation statements)

References 34 publications

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“…Although he did not understand the underlying mechanism of this growth enhancement, Bengtsson (1979) noted that thyroid hormones regulate fish growth. Much research has documented that PCBs alter thyroid hormone (T) levels in a variety of fish species (Mayer et al ., 1977; Leatherland et al ., 1978; Fingerman & Russell, 1980; Besselink et al ., 1996; Palace et al ., 2001; Brown et al ., 2004) although the pattern of whether T 3 or T 4 is more affected, and the dynamic changes in response to dose and over time seems to be complex and variable by species.…”

Section: Introductioncontrasting

confidence: 52%

Age structure and growth of Semotilus atromaculatus(Mitchill) in PCB‐contaminated streams

Henshel

Sparks

Simon

et al. 2006

Journal of Fish Biology

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Creek chub Semotilus atromaculatus from two PCB contaminated streams (Clear Creek and Richland Creek) at three locations and a reference stream (Little Indian Creek), Indiana, U.S.A., were examined to determine if age class structure and growth variables were correlated with in-situ PCB exposure. Approximately five to 15 fish were captured weekly during the spring spawning season and monthly thereafter for a 12 month period. Fish collected ranged from 25 to 267 mm total length (L T ). Throughout the course of this study, no spawning activity was observed at either location in Clear Creek, although some very small young-of-the-year (YOY) creek chub fry were observed at the downstream location by late summer. Creek chub nests were observed in both Richland Creek and Little Indian Creek but YOY were common only in Little Indian Creek. Exposure to PCBs was shown to both enhance and decrease growth in varied laboratory tests; subtle but significant gender-specific differences in the growth of creek chub populations between the sites were observed. Creek chub up to 24 months in age from Clear Creek and Richland Creek were significantly larger (both L T and mass for males and L T for females) than reference site creek chub. This trend was reversed for creek chub aged !24 months as the reference site fish were consistently larger with reference males weighing significantly more. Older age classes of creek chub were missing in areas of higher PCB contamination. Female population growth rates and individual instantaneous growth rates were consistently higher at the reference site in comparison to the PCB-contaminated sites. Calculation of 'functional b' (as a condition factor) did indicate that growth enhancement in young males did occur at the most contaminated site and reductions in growth (mass relative to L T ) occurred in females from all contaminated sites. Furthermore, longterm survivorship for females was reduced in the PCB-contaminated streams. All of these subtle alterations in growth would not have been observed if males and females had not been analysed separately.

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Section: Introductioncontrasting

confidence: 52%

Age structure and growth of Semotilus atromaculatus(Mitchill) in PCB‐contaminated streams

Henshel

Sparks

Simon

et al. 2006

Journal of Fish Biology

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“…3), since, after i.p. injection of flounder with Clophen A50, Besselink et al (1996) stated that, for instance, floun-der is not a species sensitive to PCB exposure, which is consistent with the findings of Eggens et al (1996). However, also dab may not be induced consistently well by PCBs and may need relatively high concentrations, as suggested when looking at the levels of PCBA60 able to induce EROD activity in Figs.…”

Section: Resultssupporting

confidence: 70%

Ethoxyresorufin O-deethylase (EROD) activity in the liver of dab ( Limanda limanda L.) and flounder ( Platichthys flesus L.) from the German Bight. EROD expression and tissue contamination

Westernhagen

Krüner

Broeg

1999

Helgoland Marine Research

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Abstract. Ethoxyresorufin O-deethylase (EROD) activity was measured in the liver of dab (Limanda limanda) and flounder (Platichthys flesus) from the German Bight (southern North Sea) and compared with muscle and liver polychlorinated biphenyl (PCB) concentrations in an attempt to relate EROD activity to PCB body burden. In none of the different datasets (species-, tissue-or matrixdependent) was a significant (P<0.05) correlation between PCB tissue contamination and EROD activity found. Yet EROD activity was significantly correlated with polycyclic aromatic hydrocarbons (PAH) levels (phenanthrene, fluoranthene, pyrene) in muscle tissue, indicating a possible dependence of EROD expression on other ubiquitous organic contaminants, thus making it a suitable biomarker for general pollution.

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“…T 3 is the active form of THs and it is largely produced by the peripheral enzymatic monodeiodination of T 4 mainly in the liver and other tissues (Van der Geyten et al, 1998). Most of the chemical compounds such as polychlorinated biphenyls and pesticides can lead to increase of T 3 in blood by altering 5 -deiodinase activity in fish (Besselink et al, 1996;Adams et al, 2000;Coimbra et al, 2005;Picard-Aitken et al, 2007;Peter et al, 2009;Yu et al, 2011;Guo and Zhou, 2013;Yu et al, 2013). In this study, the observed increase in plasma T 3 level may be a response to maintenance of the basal metabolic rate of the fish to ensure its survival.…”

Section: Discussionmentioning

confidence: 55%

Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures

Saravanan

Hur

Narayanasamy³

et al. 2014

Environmental Toxicology and Pharmacology

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Low hepatic 7-ethoxyresorufin-O-deethylase (EROD) activity and minor alterations in retinoid and thyroid hormone levels in flounder (Platichthys flesus) exposed to the polychlorinated biphenyl (PCB) mixture, Clophen A50

Cited by 31 publications

References 34 publications

Age structure and growth of Semotilus atromaculatus(Mitchill) in PCB‐contaminated streams

Age structure and growth of Semotilus atromaculatus(Mitchill) in PCB‐contaminated streams

Ethoxyresorufin O-deethylase (EROD) activity in the liver of dab ( Limanda limanda L.) and flounder ( Platichthys flesus L.) from the German Bight. EROD expression and tissue contamination

Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures

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