Changes of NGF level in mouse hypothalamus following intermale aggressive behaviour: Biological and immunohistochemical evidence

Aloe, Luigi; Alleva, Enrico; Simone, Roberta De

doi:10.1016/0166-4328(90)90120-4

Cited by 66 publications

(33 citation statements)

References 33 publications

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“…Not only the BDNF expression, but also the prototype NGF had been found to be altered significantly in stress caused by various reasons in animal models (123,142); it was found raised in maternal deprivation in rats (123); and specific hypothalamic nuclei were reported having raised 'NGF' levels in aggression in mice (95). Occasional reports also implicated NT-3 in stress (108).…”

Section: Evidences From Animal Model Studiesmentioning

confidence: 99%

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

Kumar¹,

Kumar²,

Pareek³

et al. 2017

Preprint

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Apart from their established role in embryonic development Nerve Growth Factors (NGFs) have diverse functions in the nervous system. Their role in integration of physiological functioning of the nervous system is now attracting attention. In the present analysis, we propose a new paradigm about a novel role of NGFs. We hypothesize that NGFs play imperative role in maintaining psychological integrity of an individual as a biological system. This function may be mediated through HPA-axis-operated homeostatic mechanisms; stress induced disruption of which may lead to psychiatric disorders.

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Section: Evidences From Animal Model Studiesmentioning

confidence: 99%

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

Kumar¹,

Kumar²,

Pareek³

et al. 2017

Preprint

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“…The observation that stress can produce significant alterations in circulating NGF levels [13][14][15][16][17] raised the question as to whether exposure to stress also affects the local expression of NGF and its receptors, p75NTR and TrkA, in murine hair follicles.…”

Section: Stress Up-regulates Epithelial Expression Of Ngf and Its Recmentioning

confidence: 99%

“…[7][8][9][10][11] Besides SP and classical stress-related neurohormones like cortisolreleasing hormone (CRH), adrenocorticotropic hormone (ACTH), and prolactin (PRL), 9,12 nerve growth factor (NGF) is now recognized as a decisive factor involved in stress responses. 13,14 Recent findings indicate that circulating levels of NGF undergo significant variations after exposure to stressful events. [15][16][17] In the context of the "brain-hair follicle axis", NGF is particularly interesting since it is known to increase the number of peptidergic nerve fibers and induce the release of sensory neuropeptides such as SP.…”

mentioning

confidence: 99%

Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor

Peters

Handjiski

Kuhlmei

et al. 2004

The American Journal of Pathology

110

156

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Recently, we have revealed the existence of a "brainhair follicle axis" in murine skin and have identified the neuropeptide substance P (SP) as a key mediator of stress-induced hair growth inhibition in vivo. Published evidence suggests that increased numbers of SP-immunoreactive sensory fibers, as seen in the dermis of stressed mice in anagen-catagen transition, are a result of transient high levels of nerve growth factor (NGF). Thus, we now aimed at dissecting the role of NGF in stress-triggered hair growth termination in our murine model. By real time PCR and immunohistochemistry, stress-exposed mice showed an up-regulation of NGF and its low-affinity receptor p75NTR; the NGF high-affinity receptor TrkA was moderately down-regulated. On neutralization of NGF, premature onset of catagen, apoptosis, and increased number/ activation of perifollicular mast cells and antigen-presenting cells, which reflects the skin response to stress, was significantly abrogated. Stress or subcutaneous injection of recombinant NGF (to mimic stress) resulted in an increased percentage of SP ؉ neurons in dorsal root ganglia, as measured by retrograde tracing. Taken together, these data suggest that NGF is a central element in the perifollicular neurogenic inflammation that develops during the murine skin response to stress and antagonizing NGF may be a promising therapeutic approach to counter the negative effect of stress on hair growth. Recently, we have introduced a mouse model launching experimental evidence that stress-induced hair loss is fact, and not fiction, as every so often imputed by a number of dermatologists. This mouse model provides new insights into the pathophysiology of stress-induced hair growth inhibition and permits exploration of various strategies for therapeutic intervention. 1,2 In this model, exposure to sonic stress inhibits the growth of a hair shaft producing (anagen) hair follicle by premature induction of hair follicle regression (catagen) and up-regulated keratinocyte apoptosis. At the same time, it induces neurogenic inflammation characterized by perifollicular mast cell degranulation and accumulation of antigen-presenting cells, eg, activated macrophages. 3 The neuropeptide substance P (SP) was identified as a key mediator of stress-induced hair growth inhibition, since increased number of SP-immunreactive nerve fibers were present in the skin of stressed mice and hair growth inhibition could be blocked by SP-receptor antagonists.

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“…In addition to its well-known effect on cells of the nervous system, NGF has been shown to be involved in the regulation of specific neuroendocrine functions (6,17). Studies first reported from our laboratory showed that psychosocially stressful events characterized by release of biologic compounds from endocrine glands, such as ACTH and corticosteroid (15, 16), are also characterized by an increase of both the circulating levels of NGF and the NGF mRNA synthesis in the hypothalamus (54).…”

Section: Ngf and The Endocrine Systemmentioning

confidence: 99%

“…The functional significance of the large amounts of NGF observed in the mouse SG is not fully understood, though recent studies reported by our laboratory and other laboratories have demonstrated that the NGF produced in the SG is released into the bloodstream after intraspecific aggressive behavior (15, 16) and acts not only on nerve cells and chromaffin cells, but also on several immune cells such as mast cells (MC) and lymphocytes (17)(18)(19)(20). These observations led to the hypothesis that salivary NGF may play a functional role in these cells.…”

mentioning

confidence: 99%

The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases

Aloe

Bracci-Laudiero

Бонини

et al. 1997

Allergy

Self Cite

200

124

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Numerous studies published in the last 10–15 years have shown that nerve growth factor (NGF), a polypeptide originally discovered in connection with its neurotrophic activity, also acts on cells of the immune system. NGF has been found in various immune organs including the spleen, lymph nodes, and thymus, and cells such as mast cells, eosinophils, and B and T cells. The circulating levels of NGF increase in inflammatory responses, in various autoimmune diseases, in parasitic infections, and in allergic diseases. Stress‐related events both in animal models and in man also result in an increase of NGF, suggesting that this molecule is involved in neuroendocrine functions. The rapid release of NGF is part of an alerting signal in response to either psychologically stressful or anxiogenic conditions in response to homeostatic alteration. Thus, the inflammation and stress‐induced increase in NGF might alone or in association with other biologic mediators induce the activation of immune cells during immunologic insults. A clearer understanding of the role of NGF in these events may be useful to identify the mechanisms implicated in certain neuroimmune and immune dysfunctions.

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Changes of NGF level in mouse hypothalamus following intermale aggressive behaviour: Biological and immunohistochemical evidence

Cited by 66 publications

References 33 publications

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor

The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases

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