Cognitive function in major depression

Austin, Marie‐Paule; Ross, M.; Murray, CS; O’Carroll, Ronan E.; Ebmeier, Klaus P.; Goodwin, Guy M.

doi:10.1016/0165-0327(92)90089-o

Cited by 288 publications

(198 citation statements)

References 23 publications

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“…In contrast, bipolar patients are unimpaired on the TMT-A [14][15]. As with the CPT, performance on these measures of attention correlates to symptom severity [13]. Taken together, these reports indicate that patients with mood disorders can experience measurable deficits of attention during euthymic and disturbed mood states.…”

Section: Attention and Working Memorymentioning

confidence: 79%

“…The Trail Making Test, Part A (TMT-A) [9] and the Digit Symbol Substitution Test (DSST) [10] involve attentional and working memory components. Unipolar depressed patients when acutely ill or when euthymic show deficits in both of these tasks [11][12][13]. In contrast, bipolar patients are unimpaired on the TMT-A [14][15].…”

Section: Attention and Working Memorymentioning

confidence: 99%

“…Similarly, patients in either acute manic or euthymic mood states have demonstrated significant impairments on the Stroop Test [6,12,14]. Austin et al [13] showed that performance on the TMT-B was impaired for depressed patients and worsened with a patient's level of depression.…”

Section: Executive Functionmentioning

confidence: 99%

“…Impairments have been reported during the depressed, manic, and euthymic phases of illness in tests of verbal memory, such as story recitation [6] and word list recall [12][13]15,18]. One study comparing depressed and euthymic patients versus healthy controls found an additional impairment for nonverbal memory, but only in acutely depressed patients, whereas the nonverbal memory performance for euthymic patients was comparable to that of controls [19].…”

Section: Memorymentioning

confidence: 99%

“…One study comparing depressed and euthymic patients versus healthy controls found an additional impairment for nonverbal memory, but only in acutely depressed patients, whereas the nonverbal memory performance for euthymic patients was comparable to that of controls [19]. As with other cognitive processes, memory function worsens with mood severity [13].…”

Section: Memorymentioning

confidence: 99%

See 4 more Smart Citations

Cognitive and neurological impairment in mood disorders

Marvel

Paradiso

2004

Psychiatric Clinics of North America

202

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Section: Attention and Working Memorymentioning

confidence: 79%

Section: Attention and Working Memorymentioning

confidence: 99%

Section: Executive Functionmentioning

confidence: 99%

Section: Memorymentioning

confidence: 99%

Section: Memorymentioning

confidence: 99%

See 3 more Smart Citations

Cognitive and neurological impairment in mood disorders

Marvel

Paradiso

2004

Psychiatric Clinics of North America

202

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Prefrontal Cortical Deficits in Type 1 Diabetes Mellitus

Lyoo¹,

Yoon

Jacobson

et al. 2012

Arch Gen Psychiatry

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Context Neural substrates that may be responsible for the high prevalence of depression in type 1 diabetes mellitus (T1DM) have not yet been elucidated. Objective To investigate neuroanatomic correlates of depression in T1DM. Design Case-control study using high-resolution brain magnetic resonance images. Settings Joslin Diabetes Center and McLean Hospital, Massachusetts, and Seoul National University Hospital, South Korea. Participants A total of 125 patients with T1DM (44 subjects with ≥1 previous depressive episodes [T1DM-depression group] and 81 subjects who had never experienced depressive episodes [T1DM-only group]), 23 subjects without T1DM but with 1 or more previous depressive episodes (depression group), and 38 healthy subjects (control group). Main Outcome Measures Spatial distributions of cortical thickness for each diagnostic group were compared with the control group using a surface-based approach. Among patients with T1DM, associations between metabolic control measures and cortical thickness deficits were examined. Results Thickness reduction in the bilateral superior prefrontal cortical regions was observed in the T1DM-depression, T1DM-only, and depression groups relative to the control group at corrected P<.01. Conjunction analyses demonstrated that thickness reductions related to the influence of T1DM and those related to past depressive episode influence were observed primarily in the superior prefrontal cortical region. Long-term glycemic control levels were associated with superior prefrontal cortical deficits in patients with T1DM (β = −0.19, P = .02). Conclusions This study provides evidence that thickness reduction of prefrontal cortical regions in patients with T1DM, as modified by long-term glycemic control, could contribute to the increased risk for comorbid depression.

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The effects of fluoxetine and dothiepin on cognitive function in depressed patients in general practice

Fairweather

Stanley

Yoon

et al. 1999

Hum. Psychopharmacol. Clin. Exp.

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The objective of this study was to assess whether there are any dierences between¯uoxetine and dothiepin on cognitive function of patients with major depression (DSMIII-R). A randomized, double-blind, parallel group design, 6 week trial in patients in general practice was employed where patients were randomly allocated to one of two treatment groups, i.e.¯uoxetine 20 mg mane or dothiepin 75 mg nocte (increasing to 150 mg in the 2nd week). Eighty-four depressed patients aged 18±70 (mean 43 . 8) years were admitted to the study. Cognitive function was assessed by a valid battery of tests before and during treatment. The severity of depression was assessed using the Hamilton Depression Rating Scale (HAMD) at the start and end of the study. Both treatments were similarly ecacious in reducing the HAMD and performance tended to improve with both drugs during treatment. There were signi®cant dierences between the drugs on the critical¯icker fusion task where the¯uoxetine group performed signi®cantly better than the dothiepin group (p 5 0.05). The¯uoxetine group also had better scores on a mental arithmetic task. No signi®cant dierences were observed in the adverse event pro®les. The results of this study show that¯uoxetine and dothiepin cannot be dierentiated in terms of ecacy manifest by changes in the HAMD, but do possess dierent pro®les of action on the battery of cognitive tests.

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Cognitive function in major depression

Cited by 288 publications

References 23 publications

Cognitive and neurological impairment in mood disorders

Cognitive and neurological impairment in mood disorders

Prefrontal Cortical Deficits in Type 1 Diabetes Mellitus

The effects of fluoxetine and dothiepin on cognitive function in depressed patients in general practice

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