Angiographic evidence of basilar artery constriction in the rabbit: A new model of vasospasm

Baker, Keith F.; Zervas, Nicholas T.; Pile‐Spellman, John; Vacanti, Francis X.; Miller, D. Douglas

doi:10.1016/0090-3019(87)90280-1

Cited by 48 publications

(24 citation statements)

References 23 publications

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“…Injections of homologous blood into the cisterna magna twice (second injection usually 2 days after the 302 TODA AND OKAMURA first) evokes experimentally induced delayed vasospasm in dogs, rabbits, cats, monkeys, baboons, and rats (Echlin, 1965;Liszczak et al, 1983;Svendgaard et al, 1983;Sasaki et al, 1985;Baker et al, 1987;Otsuji et al, 1994). Mechanisms underlying the vasospasm have been analyzed intensively in these animal models to provide effective prophylactic maneuvers.…”

Section: A Cerebral Vasospasm After Subarachnoid Hemorrhagementioning

confidence: 99%

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

2003

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Section: A Cerebral Vasospasm After Subarachnoid Hemorrhagementioning

confidence: 99%

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

2003

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“…In all SAH groups, an injection of blood into the cisterna magna was performed to produce a SAH model [11]. The rabbits were anaesthetized with an intramuscular injection of a mixture of ketamine (25 mg/kg) and droperidol (1.0 mg/kg) on day 0.…”

Section: Induction Of Experimental Sahmentioning

confidence: 99%

Expression of Toll-like receptor 4 in the brain in a rabbit experimental subarachnoid haemorrhage model

et al. 2007

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“…In rabbits, the proposed techniques include the single and the double injection models in which the blood is intrathecally injected only once and twice, respective-ly [4,26,41,42,48,51]. Review of the previous investigations seems to indicate superiority of the single injection model over the double injection model, because the severity of the available vasospasm was not very different from each other and mortality was higher with the double injection technique.…”

Section: Experimental Sah Modelmentioning

confidence: 99%

Development of calcitonin gene-related peptide slow-release tablet implanted in CSF space for prevention of cerebral vasospasm after experimental subarachnoid haemorrhage

et al. 1996

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The calcitonin gene-related peptide (CGRP), a known potent intrinsic cerebral vasodilator, is contained in the sensory nerves from trigeminal ganglia that inervate the cerebral arteries. We previously reported that human alpha CGRP (hCGRP) dilates spastic cerebral arteries after experimental subarachnoid haemorrhage (SAH) in rabbits. In the present study, we investigated the prophylactic potential of a sustained higher cerebrospinal fluid level of hCGRP against experimental cerebral vasospasm. An hCGRP slow-release tablet (hCGRP s-r tablet) was developed for cisternal implantation. Experimental SAH was induced by percutaneous cisternal injection of autologous arterial blood. Angiography was initiated on day 1 (before SAH) and performed everyday. The hCGRP s-r tablet was implanted into the cisterna magna on day 2 in the treated groups. The spastic response of the basilar artery was maximized on day 4 in the non-treated (80.7% of day 1) and the placebo-treated (79.3%) groups. In contrast, the arterial diameters on day 4 were 96.1% and 90.5% of day 1 in the groups implanted with hCGRP 24 micrograms and 153 micrograms s-r tablets, respectively. We also measured the concentration of hCGRP in the cerebrospinal fluid (CSF) following implantation of the hCGRP 24 micrograms s-r tablet in the cisterna magna. The hCGRP concentration before implantation was below the dectable level. Following implantation, the hCGRP level in the CSF was 23.12 nmol/L on the second day and remained at elevated levels until the fifth day. These experiments suggest that the intrathecal single implantation of the hCGRP s-r tablet could produce an elevated concentration of hCGRP in the CSF over five days and have prevented the cerebral vasospasm after SAH in the rabbit. The hCGRP s-r tablet may be clinically applicable in the treatment of patients with SAH against cerebral vasospasm.

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Angiographic evidence of basilar artery constriction in the rabbit: A new model of vasospasm

Cited by 48 publications

References 23 publications

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

Expression of Toll-like receptor 4 in the brain in a rabbit experimental subarachnoid haemorrhage model

Development of calcitonin gene-related peptide slow-release tablet implanted in CSF space for prevention of cerebral vasospasm after experimental subarachnoid haemorrhage

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