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Cited by 43 publications
(13 citation statements)
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“…The mechanism of this phenomenon may be similar to the latency of peroxisomal catalase (Baudhuin, 1969;Poole, 1975). We used two tests, analogous to those described earlier for catalase (Baudhuin, 1969), to confirm this assumption.…”
Section: Journal Of Cell Science 117 (23)mentioning
confidence: 57%
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“…The mechanism of this phenomenon may be similar to the latency of peroxisomal catalase (Baudhuin, 1969;Poole, 1975). We used two tests, analogous to those described earlier for catalase (Baudhuin, 1969), to confirm this assumption.…”
Section: Journal Of Cell Science 117 (23)mentioning
confidence: 57%
“…A high peroxisomal concentration of an enzyme may lead to conditions where its activity is greater than the rate of transmembrane transfer of the substrate (Baudhuin, 1969;Poole, 1975) (see also Results). Two tests have been described to verify this mechanism (Baudhuin, 1969).…”
Section: Latency Of Peroxisomal Lactate Dehydrogenasementioning
confidence: 97%
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“…H 2 O 2 flux across the peroxisomal membrane was modeled in a similar fashion by using the concentration of peroxide in the cytosol and the concentration of peroxide in the peroxisome to generate the gradient force for diffusion. The permeability coefficient of H 2 O 2 through the peroxisomal membrane, P, was obtained from the literature (38), assuming a uniform concentration of H 2 O 2 within a particular compartment.…”
Section: Membrane H 2 O 2 Transportmentioning
confidence: 99%
“…It is well known that 07 and H202 react rapidly to yield the hydroxyl radical. It is pertinent to note that catalase is not highly effective in destroying H202 present at low concentrations (33,38) and that some of the H202 generated in peroxisomes can escape degradation by catalase even in the normal liver (39). Since it is evident that H202 is formed in excess in the liver as a consequence of drug-induced peroxisome proliferation and that these livers exhibit increased lipid peroxidation (40), it will now be of interest to determine the extent to which endogenously generated H202 as well as 07 produced by peroxisomal membrane oxidase contributes to OH generation and DNA damage in vivo.…”
Section: Discussionmentioning
confidence: 99%