Non-invasive measurement of long bone cross-sectional moment of inertia by photon absorptiometry

Martin, R. Bruce; Burr, David B.

doi:10.1016/0021-9290(84)90010-1

Cited by 229 publications

(135 citation statements)

References 17 publications

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“…The r(x, y)/r NIST term defines the bone fraction within a pixel and accounts for partialvolume effects of the finite voxel size. This definition of the moment of inertia is consistent with that defined by Martin and colleagues (25) and is consistent with what is reported by HSA in the published literature.…”

Section: Disclosuressupporting

confidence: 91%

Volumetric DXA (VXA): A new method to extract 3D information from multiple in vivo DXA images

Taylor

Ahmad

2010

Journal of Bone and Mineral Research

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Three-dimensional geometric and structural measurements of the proximal femur are of considerable interest in understanding the strength of the femur and its susceptibility to fracture. Quantitative computed tomography (QCT) with a small voxel size ( 1 mm per side) is the current ''gold standard'' to examine the macrostructure of the femur, but it has a high effective radiation dose (approximately 2 to 5 mSv) and cost. Volumetric dual-energy X-ray absorptiometry (VXA) uses a commercially available DXA system (Hologic Discovery A) to reconstruct the proximal femur from four DXA scans delivering an effective radiation dose of 0.04 mSv. VXA was compared with QCT (voxel size of 0.29 Â 0.29 Â 1 mm) in 41 elderly women (age 82 AE 2.4 years) at slices located at the femoral neck and trochanteric regions of interest. For parameters of shape, the femoral neck axis length (FNAL) and the cross-sectional slice area (SA), accuracy and strong linear correlations (r ¼ 0.84 to 0.98) were demonstrated. Similar correlations (r ¼ 0.81 to 0.97) were observed for the density parameters, the cross-sectional bone area (CSA) and volumetric bone mineral density (vBMD). VXA also demonstrated strong correlations (r ¼ 0.76 to 0.99) for the engineering parameters of the minimum, maximum, and polar cross-sectional moments of inertia (CSMIs) and the section modulus (Z). We conclude that VXA is capable of generating a variety of 3D geometric and structural measurements that are highly correlated with QCT in elderly subjects in vivo. Moreover, the VXA measurements can be made with a commercially available DXA device at a very low radiation dose. ß

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Section: Disclosuressupporting

confidence: 91%

Volumetric DXA (VXA): A new method to extract 3D information from multiple in vivo DXA images

Taylor

Ahmad

2010

Journal of Bone and Mineral Research

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“…The current algorithm corrects effective tissue density to 1.05 g/cm 3 . 16 Although the error had no bearing on previous conclusions it has been corrected here.…”

Section: Bone and Muscle Measurementsmentioning

confidence: 89%

Stress fracture in military recruits: gender differences in muscle and bone susceptibility factors

Beck

Ruff

Shaffer

et al. 2000

Bone

279

195

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“…HSA provided measures of bone cross-sectional area (CSA, cm 2 ), section modulus (Z, cm 3 ) and subperiosteal width (WID, cm) at each of the 3 femoral regions (NN, IT, and S), These parameters are measured directly from the mass profiles using a principle first described by Martin and Burr [34]. In addition, the method measures the neck-shaft angle (NSA) and femoral neck length (FNL), defined as distance from the center of femoral head to the intersection of neck and shaft axes (Figure 1).…”

Section: Dual Energy X-ray Absorptiometry (Dxa) and Hip Structural Anmentioning

confidence: 99%

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Demissie

Dupuis

Cupples

et al. 2007

Bone

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Non-invasive measurement of long bone cross-sectional moment of inertia by photon absorptiometry

Cited by 229 publications

References 17 publications

Volumetric DXA (VXA): A new method to extract 3D information from multiple in vivo DXA images

Volumetric DXA (VXA): A new method to extract 3D information from multiple in vivo DXA images

Stress fracture in military recruits: gender differences in muscle and bone susceptibility factors

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

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