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Cited by 305 publications
(98 citation statements)
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“…At E12, the mesenchyme surrounds, but has not penetrated, the epithelium. Removal of the mesenchyme at this critical phase prevented the development of the epithelium in vitro (36). Subsequently, Shinohara and Honjo showed that the mesenchyme of the early E12 thymus influences MHC class II expression in the epithelium, but they did not study the effects on lymphopoiesis (37,38).…”
Section: Discussionmentioning
confidence: 99%
“…At E12, the mesenchyme surrounds, but has not penetrated, the epithelium. Removal of the mesenchyme at this critical phase prevented the development of the epithelium in vitro (36). Subsequently, Shinohara and Honjo showed that the mesenchyme of the early E12 thymus influences MHC class II expression in the epithelium, but they did not study the effects on lymphopoiesis (37,38).…”
Section: Discussionmentioning
confidence: 99%
“…Adherent and thymic epithelial cells thus seem to differ in their supporting roles in thymocyte maturation. The rationale for using thymic epithelium cultures was their demonstrated role in inducing thymic lymphopoesis in ontogeny (31,32). Perhaps epithelial cells ccntinue to produce an "inducing factor" during adult life which aids the in vivo maturation of thymic lymphocytes.…”
Section: Discussionmentioning
confidence: 99%
“…Already in 1960, Auerbach showed that mesenchymal cells of neural crest origin are inducers of TEC proliferation and differentiation [55]. Apart from research concentrating on the germ layers that contribute to the thymus primordium (reviewed in [56,57]), there are numerous studies with a focus on the hematopoietic -TEC interactions (reviewed in [58,59]).…”
Section: A Short Note On Thymus Organogenesismentioning
confidence: 99%