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Cited by 75 publications
(38 citation statements)
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References 35 publications
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“…It is suggested that, with age, more failures in ATP production occur due to the impaired activity of the respiratory chain complexes (Ferrandiz et al, 1994). In the present study, the older birds showed lower expression of all the mitochondrial genes analyzed -UCP, ANT, and COX III -combined with reduced productive efficiency, such as impaired feed conversion (Table 3).…”
Section: Discussionsupporting
confidence: 50%
“…It is suggested that, with age, more failures in ATP production occur due to the impaired activity of the respiratory chain complexes (Ferrandiz et al, 1994). In the present study, the older birds showed lower expression of all the mitochondrial genes analyzed -UCP, ANT, and COX III -combined with reduced productive efficiency, such as impaired feed conversion (Table 3).…”
Section: Discussionsupporting
confidence: 50%
“…Other workers found no significant agerelated declines for any of the complexes in rat brain (Filburn et al, 1996;Sandhu & Kaur, 2003). A report by Ferrándiz et al (1994) of loss of activities in non-synaptic but not in synaptic mouse mitochondria must be accepted with caution. The specific activities determined for complex I are some 30-fold too high with respect to those of the other complexes, complex II was not activated prior to assay and the possibility that preparations from older tissue contained more impurity was not excluded.…”
Section: (Iii) Brainmentioning
confidence: 96%
“…Because the metabolic capacity of neurons is determined by their ability to use ATP for the high energy-requiring membrane potentials involved in synaptic transmission, a sustained increase in the energy demand of the cell requires increased production of the CO enzyme [39]. Assessment of CO enzymatic activity in the brain has mainly been used to investigate relatively large metabolic changes in neuronal activity such as those elicited after eye enucleation [40,41], disruption of blood circulation or hypoxia [42,43], ageing [44], and electroconvulsive treatment [45], though more subtle applications to learning [46][47][48] and chronic exercise [49] have also been undertaken. Unlike other types of metabolic mapping such as 2-deoxyglucose, whose uptake is determined by neuronal activity during experimental periods of 25-45 min, CO mapping reveals neuronal activity as it occurs over long periods (hours to weeks), with changes that persist after cessation of the specific behavior.…”
Section: Studies In Freely Moving Animalsmentioning
confidence: 99%