Psychophysiological correlates of posttraumatic stress disorder in Vietnam veterans

Paige, Stephen R.; Reid, Graham M.; Allen, Mary Gwyn; Newton, Joseph E. O.

doi:10.1016/0006-3223(90)90552-d

Cited by 111 publications

(70 citation statements)

References 19 publications

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“…Consistent with their predictions, Paige and colleagues found that Vietnam veterans with PTSD had significantly reduced P2 amplitude intensity slopes compared with veterans without PTSD [1]. This pattern of decreased intensity dependence was replicated in a second study of male Vietnam combat veterans [9], supporting the position that male Vietnam veterans with PTSD more readily enter a state of protective inhibition when presented with high-intensity stimuli.…”

Section: Introductionmentioning

confidence: 65%

“…In 1990, Paige and colleagues published a seminal study applying event-related potential (ERP) methodology to the investigation of central nervous system function in posttraumatic stress disorder (PTSD) [1]. Using a four-tone, stimulus-intensity modulation (i.e., augmenting-reducing) paradigm [2], the investigators measured the slope of the function that related the amplitude of the P2 component to increasing sound intensity levels (74, 84, 94, and 104 dB) in male Vietnam combat veterans with and without PTSD.…”

Section: Introductionmentioning

confidence: 99%

“…Using a four-tone, stimulus-intensity modulation (i.e., augmenting-reducing) paradigm [2], the investigators measured the slope of the function that related the amplitude of the P2 component to increasing sound intensity levels (74, 84, 94, and 104 dB) in male Vietnam combat veterans with and without PTSD. Because PTSD is characterized by heightened nervous system sensitivity, Paige and colleagues proposed that veterans with PTSD would show a reduction in the amplitude of the P2 component at higher tone-intensity levels, producing a shallow amplitude intensity slope [1]. Termed "reducing" by early investigators [3], this ERP response pattern of decreased intensity dependence is believed to reflect a protectively tuned sensory system that protects the organism from sensory overload via a central gating mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…Methodological differences also exist between studies. Although Metzger et al [11] employed a paradigm that closely paralleled the original study of Vietnam veterans [1], the paradigm and slope measurement used by McPherson and colleagues [10] differed considerably from those used in the studies of male combat veterans [1,9]. For example, the study by McPherson and colleagues used longer interstimulus intervals and employed a monetary incentive button-press task, whereas the remaining studies used a passive listening paradigm [10].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: Associations with posttraumatic stress disorder

Metzger

Pitman²,

Miller³

et al. 2008

JRRD

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Abstract-Two studies have reported decreased intensity dependence of the P2 event-related potential (ERP) in male combat veterans with posttraumatic stress disorder (PTSD), a response pattern presumed to reflect central nervous systeminduced protective inhibition and heightened central serotonergic activity. We used an identical twin, case-control design to investigate whether intensity dependence abnormalities reflect pretrauma vulnerability or are an acquired consequence of PTSD. ERPs were measured in male Vietnam combat veterans and their noncombat-exposed monozygotic twin brothers during a four-tone, stimulus-intensity modulation procedure. Contrary to previous findings in male veterans, the PTSD group had significantly steeper P2 amplitude intensity slopes, similar to those reported for female veterans and abused children with PTSD. Additionally, increased P2 amplitude intensity slope was associated with increased PTSD symptom severity, particularly the severity of reexperiencing symptoms. A mixed-model, random-effects analysis that included the combat-unexposed twins revealed a significant diagnosis by combat exposure interaction. Inspection of group means suggests that the observed increased P2 intensity dependence is a consequence of PTSD. Our findings further suggest that low serotonergic tone may emerge as one potential consequence of this disorder.

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Section: Introductionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: Associations with posttraumatic stress disorder

Metzger

Pitman²,

Miller³

et al. 2008

JRRD

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show abstract

“…The condition features the core symptoms of re-experiencing, avoidance and hyperarousal [2,3] , in tandem with a high rate of dissociative experience [4] . However, the pathogenesis of PTSD remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

et al. 2012

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Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.

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Child Maltreatment and the Development of Posttraumatic Stress Disorder

Famularo¹

1993

Arch Pediatr Adolesc Med

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Psychophysiological correlates of posttraumatic stress disorder in Vietnam veterans

Cited by 111 publications

References 19 publications

Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: Associations with posttraumatic stress disorder

Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: Associations with posttraumatic stress disorder

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

Child Maltreatment and the Development of Posttraumatic Stress Disorder

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