Paraquat-induced chemiluminescence of microsomal fractions

Biological Chemiluminescence

“…8). The redox cycling-supported light emission is sensitive to superoxide dismutase, thus pointing to the relevance of 02-' in the chemiluminescence observed during redox cycling of paraquat (Cadenas et al, 1983a) and menadione (Wefers & Sies, 1983). The molecular mechanism for the generation of excited species are apparently different from those described above, and seem to be multifaceted.…”

“…Examples are given by the chemiluminescence observed during oxidation of adrenaline, adrenochrome (Slawinska, 1978) and other quinones (Slawinska & Slawinski, 1973), the autoxidation of 6-hydroxydopamine (Heikkila & Cabbat, 1978), the one-electron activation of paraquat (Cadenas et al, 1983a) and menadione (Wefers & Sies, 1983), the iron/H20z-mediated activation of bleomycin (Trush et al, 1983) the nonenzymatic (presumably H20 2/02-· mediated) oxidation of pbenzoquinone (Ginsberg & Cadenas, 1985) and the enzymatic oxidation of cathecol (Villablanca & Cilento, 1985).…”

The role of singlet oxygen and triplet carbonyls in biological systems

“…Examples are the chemiluminescence observed during the oxidation of adrenaline, adrenochrome f20I] and other quinones [2021, autoxidation of 6-hydroxydopamiue [2031, one-electron activation of paraquat [204] and menadioue [205], iron/azOz-mediated activation of bleomycin [206], non-enzymatic (presumably HzOz/O~--mediated) oxidation of p-benzoquinone [71], enzymatic oxidation of catechol {70] and enzymatic oxidation of tannins [207] and lignin [2081.…”

“…This redox cycling process promotes the generation of excited states which leads to low-level chemiluminescence. The redox cycling-supported light emission is sensitive to superoxide dismutase, thus pointing to the relevance of O~-in the chemiluminescence observed during redox cycling of paraquat [204] and menadione [205].…”

Mechanism of paraquat-stimulated lipid peroxidation in mouse brain and pulmonary microsomes

“…although high concentrations of oxygen enhance the paraquat toxicity (Selman et al 1985). In addition, there have been reports indicating both stimulation and inhibition of lipid peroxidation by paraquat in-vitro (Bus et al 1974;Misra & Gorsky 1981;Trush et al 1981;Cadenas et al 1983).…”