ADP-iron as a fenton reactant: Radical reactions detected by spin trapping, hydrogen abstraction, and aromatic hydroxylation

Gutteridge, John M.C.; Zs.‐Nagy, Imre; Maidt, Lindsay; Floyd, Robert A.

doi:10.1016/0003-9861(90)90599-t

Cited by 47 publications

(15 citation statements)

References 29 publications

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“…Therefore, here, 2-deoxy-ribose was a less efficient scavenger, as compared to DMPO, and reduced DMPO-OH adduct concentration by 25% at 2 mM DMPO and 2 mM 2-deoxy-ribose. A similar observation was made by Gutteridge who showed that at 50 mM DMPO and 50 mM 2-deoxy-ribose, the latter inhibited formation of the DMPO-OH adduct by 45% in phosphate buffer (pH 7.4) and 0.1 mM Fe(II) salt [43].…”

Section: Search For Biocompatible Modulators Of Cu(i)-induced Fenton supporting

confidence: 81%

Can nucleotides prevent Cu-induced oxidative damage?

Baruch-Suchodolsky

Fischer

2008

Journal of Inorganic Biochemistry

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Section: Search For Biocompatible Modulators Of Cu(i)-induced Fenton supporting

confidence: 81%

Can nucleotides prevent Cu-induced oxidative damage?

Baruch-Suchodolsky

Fischer

2008

Journal of Inorganic Biochemistry

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“…AntiOxBENs antiperoxidative activity ranked differently according the method used, most likely because of the different inducing agents used and their iron-chelating in the above-properties (Fig. 3c and d) 37 . Thus, it is possible that AntiOxBENs can operate by an indirect mechanism and contribute to inhibit iron-mediated ROS generation through their iron-chelation properties.…”

Section: Discussionmentioning

confidence: 99%

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

Teixeira

Oliveira

Amorim

et al. 2017

Sci Rep

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Oxidative stress and mitochondrial dysfunction have been associated with metabolic and age-related diseases. Thus, the prevention of mitochondrial oxidative damage is nowadays a recognized pharmacological strategy to delay disease progression. Epidemiological studies suggested an association between the consumption of polyphenol-rich diet and the prevention of different pathologies, including diseases with a mitochondrial etiology. The development of mitochondrial-targeted antioxidants based on dietary antioxidants may decrease mitochondrial oxidative damage. Herein, we report the design and synthesis of two new mitochondriotropic antioxidants based on hydroxybenzoic acids (AntiOxBENs). The results obtained showed that the novel antioxidants are accumulated inside rat liver mitochondria driven by the organelle transmembrane electric potential and prevented lipid peroxidation, exhibiting low toxicity. Some of the observed effects on mitochondrial bioenergetics resulted from an increase of proton leakage through the mitochondrial inner membrane. The new derivatives present a higher lipophilicity than the parent compounds (protocatechuic and gallic acids) and similar antioxidant and iron chelating properties. AntiOxBENs are valid mitochondriotropic antioxidant prototypes, which can be optimized and used in a next future as drug candidates to prevent or slow mitochondrial oxidative stress associated to several pathologies.

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“…[38]. Other biological Fe(II) complexes with appreciable reactivity in the Fenton reaction include those of oxalate [78], pyrophosphate [79] and various nucleotides [23,62,79,80]. Phytate (myo-inositol hexaphosphoric acid), a major component of dietary fibre, blocks • OH production by the iron-catalysed Haber-Weiss reaction, which has been proposed to underlie its role in the protection of dormant seeds and other plant materials [81].…”

Section: ·2mentioning

confidence: 99%

Chemical, Biological and Medical Controversies Surrounding the Fenton Reaction

Burkitt

2003

Progress in Reaction Kinetics and Mechanism

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A critical evaluation is made of the role of the Fenton reaction (Fe2+ + H2O2 → Fe3+ + •OH + OH-) in the promotion of oxidative damage in mammalian systems. Following a brief, historical overview of the Fenton reaction, including the formulation of the Haber–Weiss cycle as a mechanism for the catalysis of hydroxyl radical production, an appraisal is made of the biological relevance of the reaction today, following recognition of the important role played by nitric oxide and its congers in the promotion of biomolecular damage. In depth coverage is then given of the evidence (largely from EPR studies) for and against the hydroxyl radical as the active oxidant produced in the Fenton reaction and the role of metal chelating agents (including those of biological importance) and ascorbic acid in the modulation of its generation. This is followed by a description of the important developments that have occurred recently in the molecular and cellular biology of iron, including evidence for the presence of ‘free’ iron that is available in vivo for the Fenton reaction. Particular attention here is given to the role of the iron-regulatory proteins in the modulation of cellular iron status and how their functioning may become dysregulated during oxidative and nitrosative stress, as well as in hereditary haemochromatosis, a common disorder of iron metabolism. Finally, an assessment is made of the biological relevance of ascorbic acid in the promotion of hydroxyl radical generation by the Fenton reaction in health and disease.

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ADP-iron as a fenton reactant: Radical reactions detected by spin trapping, hydrogen abstraction, and aromatic hydroxylation

Cited by 47 publications

References 29 publications

Can nucleotides prevent Cu-induced oxidative damage?

Can nucleotides prevent Cu-induced oxidative damage?

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

Chemical, Biological and Medical Controversies Surrounding the Fenton Reaction

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