Treatment of Blepharospasm with Botulinum Toxin

Tsoy, Edward A.; Buckley, Edward G.; Dutton, Jonathan J.

doi:10.1016/0002-9394(85)90228-4

Cited by 73 publications

(19 citation statements)

References 9 publications

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“…When injected locally, the effect is that of a chemical denervation. Injections of BOTOX locally into extraocular muscles for treatment of strabismus (6), and subcutaneously over orbicularis oculi for blepharospasm, has proven to be effective in many cases (7)(8)(9)(10)(11)(12)(13)(14). This strategy has been extended to treatment of hemifacial spasm and torticollis (7,8,10,12,15,16) with similar encouraging results.…”

Section: F Brin Et Almentioning

confidence: 99%

Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm

et al. 1987

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Medical treatment of dystonia usually results in an incomplete response and is frequently unsuccessful. Peripheral surgical therapy is available for some focal dystonias, but may only offer temporary relief and may have unacceptable complications. We have used local injections of botulinum toxin into the appropriate muscles for treatment of disabling focal or segmental dystonia in 93 patients with torticollis, blepharospasm, oromandibular dystonia (OMD), limb dystonia, lingual dystonia, and dystonia adductor dysphonia, in addition to four patients with hemifacial spasm. Significant relief of motor symptoms was seen in 69% of the patients with blepharospasm and 64% of patients with torticollis; 74% of the latter group with pain experience relief. Relief of symptoms was noted in most patients with OMD and limb dystonia, and all with lingual dystonia, dystonic adductor spastic dysphonia, and those with hemifacial spasm. Benefit averaged 2 1/2-3 months initially; however some patients experienced longer relief with subsequent injections. Adverse effects were transient, although 2 patients developed antibodies against the toxin, and we documented evidence for distant effects in others. This approach of chemically weakening contracting muscles in focal dystonia offers many advantages over pharmacotherapy and surgical therapy. Additional experience is needed to explore the proper doses, and potential for long term adverse effects.

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Section: F Brin Et Almentioning

confidence: 99%

Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm

et al. 1987

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“…The first 43 patients treated by us have already been discussed else¬ where. 13 We present here additional follow-up data on these and add an additional 34 patients to the series.…”

mentioning

confidence: 99%

Botulinum Toxin in the Management of Blepharospasm

Dutton¹,

Buckley²

1986

Archives of Neurology

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“…Blepharospasm was the first dystonia to be treated with botulinum toxin [41,42]. For blepharospasm, injections are directed to the eye closing muscle-orbicularis oculi.…”

Section: Physiology Of Botulinum Toxin In the Treatment Of Focal Hmentioning

confidence: 99%

Botulinum Toxin Physiology in Focal Hand and Cranial Dystonia

Karp

2012

Toxins

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The safety and efficacy of botulinum toxin for the treatment of focal hand and cranial dystonias are well-established. Studies of these adult-onset focal dystonias reveal both shared features, such as the dystonic phenotype of muscle hyperactivity and overflow muscle contraction and divergent features, such as task specificity in focal hand dystonia which is not a common feature of cranial dystonia. The physiologic effects of botulinum toxin in these 2 disorders also show both similarities and differences. This paper compares and contrasts the physiology of focal hand and cranial dystonias and of botulinum toxin in the management of these disorders.

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Treatment of Blepharospasm with Botulinum Toxin

Cited by 73 publications

References 9 publications

Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm

Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm

Botulinum Toxin in the Management of Blepharospasm

Botulinum Toxin Physiology in Focal Hand and Cranial Dystonia

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