Biocompatible Ag nanoparticle-embedded poly(2-hydroxyethyl methacrylate) derivative films with bacterial adhesion-resistant and antibacterial properties

Ahn, Jooyeon; Sohn, Eun‐Ho; Bang, S.-H.; Kang, Junil; Kim, Tae‐Young; Hong, Hyunkee; Kim, Seong‐Eun; Kim, Byung Soo; Yoon, Jeyong; Lee, Jong-Chan

doi:10.1007/s13233-014-2050-9

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…The surface functionalization utilizing second hydrophilic polymers such as polysaccharides (e.g., dextran and hyaluronic acid and) [17,18], poly(ethylene glycol) (PEG) [19][20][21][22], and biomembranemimicking zwitterionic polymers [e.g., 2-methacryloyloxyethyl phosphorylcholine (MPC) and carboxybetaine methacrylate (CBMA)] [23][24][25] is one such strategy to develop such "protein-resistant" biomaterials. These polymers are incorporated on biomaterial surfaces using a diverse set of surface coating and modification techniques, including physical adsorption, graft polymerization, self-assembled monolayers (SAMs), layer-by-layer assembly, interpenetrating polymer network (IPN), surface-initiated atom transfer radical polymerization (ATRP), and conventional free-radical polymerization [26][27][28][29][30][31][32][33][34]. Among these methods, the free-radical polymerization seems the most common reaction employed in the development of surface-modified hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption

et al. 2020

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A series of hydrogels with intrinsic antifouling properties was prepared via surface-functionalization of poly(2-hydroxyethyl methacrylate) [p(HEMA)]-based hydrogels with the biomembrane-mimicking zwitterionic polymer, poly(2-methacryloyloxyethyl phosphorylcholine) [p(MPC)]. The p(MPC)-modified hydrogels have enhanced surface wettability, high water content retention (61.0%–68.3%), and good transmittance (>90%). Notably, the presence of zwitterionic MPC moieties at the hydrogel surfaces lowered the adsorption of proteins such as lysozyme and bovine serum albumin (BSA) by 73%–74% and 59%–66%, respectively, and reduced bacterial adsorption by approximately 10%–73% relative to the unmodified control. The anti-biofouling properties of the p(MPC)-functionalized hydrogels are largely attributed to the dense hydration layer formed at the hydrogel surfaces by the zwitterionic moieties. Overall, the results demonstrate that biocompatible and antifouling hydrogels based on p(HEMA)-p(MPC) structures have promising potential for application in biomedical materials.

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Section: Introductionmentioning

confidence: 99%

Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption

et al. 2020

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“…This fouling layer would block the surface-tethered bactericidal agents, thereby inactivating bactericidal functionality. , Therefore, a monofunctional bactericidal coating is insufficient for preventing biofilm formation. In other words, to achieve highly effective anti-biofouling surfaces, integration of bactericidal and bacteria-repellency is highly in demand. ,, …”

Section: Introductionmentioning

confidence: 99%

Development of Multimodal Antibacterial Surfaces Using Porous Amine-Reactive Films Incorporating Lubricant and Silver Nanoparticles

Lee

Yoo

Kim

et al. 2019

ACS Appl. Mater. Interfaces

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Anti-biofouling has been improved by passive or active ways. Passive antifouling strategies aim to prevent the initial adsorption of foulants, while active strategies aim to eliminate proliferative fouling by destruction of the chemical structure and inactivation of the cells. However, neither passive antifouling strategies nor active antifouling strategies can solely resist biofouling due to their inherent limitations. Herein, we successfully developed multimodal antibacterial surfaces for waterborne and airborne bacteria with the benefit of a combination of antiadhesion (passive) and bactericidal (active) properties of the surfaces. We elaborated multifunctionalizable porous amine-reactive (PAR) polymer films from poly(pentafluorophenyl acrylate) (PPFPA). Pentafluorophenyl ester groups in the PAR films facilitate creation of multiple functionalities through a simple postmodification under mild condition, based on their high reactivity toward various primary amines. We introduced amine-containing poly(dimethylsiloxane) (amine-PDMS) and dopamine into the PAR films, resulting in infusion of antifouling silicone oil lubricants and formation of bactericidal silver nanoparticles (AgNPs), respectively. As a result, the PAR film-based lubricant-infused AgNPs-incorporated surfaces demonstrate outstanding antibacterial effects toward both waterborne and airborne Escherichia coli, suggesting a new door for development of an effective multimodal anti-biofouling surface.

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“…The development of antifouling materials is of great interest for multiple biomedical and biotechnological applications, including medical implants, contact lenses, biosensors, drug delivery, and catheters . Surface coating and modification methods that utilize antifouling polymers include physical adsorption, layer‐by‐layer (LbL) assembly, self‐assembled monolayers (SAMs), surface‐initiated atom transfer radical polymerization (ATRP), interpenetrating polymer network (IPN), and reaction of the specific groups of polymers with the substrate . Polyhydrophilic polymers, including poly(ethyleneglycol) (PEG), polysaccharides, and polyamides, and polyzwitterionic polymers, such as 2‐methacryloyloxylethyl phosphorylcholine (MPC) and carboxybetaine methacrylate (CBMA), have been employed in the development of bio‐antifouling substrates to reduce protein adsorption and biofilm formation .…”

Section: Introductionmentioning

confidence: 99%

Development of Hydrogel Lenses with Surface‐immobilized PEG Layers to Reduce Protein Adsorption

Jee

Kim

2015

Bulletin Korean Chem Soc

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This paper describes the synthesis and characterization of a series of poly(2-hydroxyethyl methacrylate) (pHEMA)-based hydrogel lenses coated with poly(ethylene glycol) (PEG) chains. A novel tri-branched PEG-substituted hydrazide is synthesized, which imparts densely packed, covalently bound PEG layers on hydrogels, to determine whether branching provides improved coverage of the lens surface, thereby reducing protein adsorption. Surface modification of hydrogels with PEG was performed via amide-coupling reactions between PEG-substituted hydrazide and the pHEMA matrix. Protein adsorption, water content, optical transparency, and surface properties of the hydrogels were investigated. The hydrogels exhibited transmittance of >90% and improved surface hydrophilicity. Notably, the amount of lysozyme adsorbed on tri-branched PEGcoated hydrogels decreased significantly compared to the amount adsorbed onto the surface of control and linear PEG-coated hydrogels. These results provide insight into the mechanism by which PEGs reduce lysozyme adsorption and suggest that PEG coating may offer an intriguing potential for ophthalmic biomaterials as well as protein-resistant devices.

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Biocompatible Ag nanoparticle-embedded poly(2-hydroxyethyl methacrylate) derivative films with bacterial adhesion-resistant and antibacterial properties

Cited by 8 publications

References 24 publications

Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption

Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption

Development of Multimodal Antibacterial Surfaces Using Porous Amine-Reactive Films Incorporating Lubricant and Silver Nanoparticles

Development of Hydrogel Lenses with Surface‐immobilized PEG Layers to Reduce Protein Adsorption

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