Adherence to the Mediterranean Diet and the Risk of Frailty in Old People: A Systematic Review and Meta-Analysis

Wang, Y.; Qin, Hao; Su, Lin; Liu, Y.; Liu, S.; Dong, Birong

doi:10.1007/s12603-018-1020-x

Cited by 80 publications

(18 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Kojima et al reported that a higher adherence to the Mediterranean diet was associated with frailty in a meta-analysis of four studies (OR = 0.44, 95% CI = 0.31–0.64, p < .001) (Kojima et al, 2018). Similar results were reported by another study of Mediterranean adherence (RR = 0.56, 95% CI = 0.36–0.89, p = 0.015) (Wang et al, 2018). The Mediterranean diet has also been associated with other measures associated with frailty including grip strength and fracture risk (Feart et al, 2013; Robinson et al, 2008).…”

Section: Discussionsupporting

confidence: 90%

Dietary Inflammatory Index and the Risk of Frailty Among Older Adults: A Systematic Review and Meta-Analysis

et al. 2020

View full text Add to dashboard Cite

A systematic review and meta-analysis was conducted to comprehensively examine the association between Dietary Inflammatory Index (DII®) score and risk of frailty. Frailty risk were available from five studies comprising 13,908 older adults. Furthermore, frailty related parameters were extacted from two studies with 7,539 individuals. A pooled adjusted odds ratio analysis indicated that there was an association between DII® score and frailty risk (OR = 1.24, 95%CI: 1.6–1.33, P < 0.001, I2 = 0.0%). The results of frailty related parameters demonstrated that DII® score was associated with weakness risk (OR = 1.12, 95%CI: 1.05–1.19, P = 0.014, I2 = 0.0%), but not other frailty-related parameters including exhaustion, low BMI or low physical activity. The results of this meta-analysis suggest that older adults who exhibit higher DII® scores have an increased frailty risk. Further prospective cohort studies with longer follow-up periods, are needed to support this possible association between DII® score and frailty risk.

show abstract

Section: Discussionsupporting

confidence: 90%

Dietary Inflammatory Index and the Risk of Frailty Among Older Adults: A Systematic Review and Meta-Analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…For instance, the traditional Mediterranean diet, characterized by the high rate of ω-3 PUFA derived from "fatty" fish (46), is associated with positive effects in cognitive and physical decline (130). Several systematic reviews and meta-analyses showed that adherence to a Mediterranean diet is associated with reduced risk of frailty, incident frailty, cognitive decline, mild cognitive impairment, Alzheimer's disease, and progression from mild cognitive impairment to Alzheimer's disease (131)(132)(133)(134)(135). A recent systematic review also showed that the Mediterranean diet is associated with myoprotective effects in several components of sarcopenia and declining physical function (136).…”

Section: Discussionmentioning

confidence: 99%

Crosstalk Between the Gut Microbiome and Bioactive Lipids: Therapeutic Targets in Cognitive Frailty

et al. 2020

View full text Add to dashboard Cite

Cognitive frailty is a geriatric condition defined by the coexistence of cognitive impairment and physical frailty. This "composite" aging phenotype is associated with a higher risk of several adverse health-related outcomes, including dementia. In the last decade, cognitive frailty has gained increased attention from the scientific community that has focused on understanding the clinical impact and the physiological and pathological mechanisms of development and on identifying preventive and/or rehabilitative therapeutic interventions. The emergence of gut microbiome in neural signaling increased the interest in targeting the gut-brain axis as a modulation strategy. Multiple studies on gastroenteric, metabolic, and neurodegenerative diseases support the existence of a wide bidirectional communication network of signaling mediators, e.g., bioactive lipids, that can modulate inflammation, gut permeability, microbiota composition, and the gut-brain axis. This crosstalk between the gut-brain axis, microbiome, and bioactive lipids may emerge as the basis of a promising therapeutic strategy to counteract cognitive frailty. In this review, we summarize the evidence in the literature regarding the link between the gut microbiome, brain, and several families of bioactive lipids. In addition, we also explore the applicability of several bioactive lipid members as a potential routes for therapeutic interventions to combat cognitive frailty.

show abstract

“…Nevertheless, from a dietary perspective, the MedDiet is often described as a plant-based dietary pattern, consistent with a high intake of vegetables, fruits, nuts, legumes, unprocessed cereals, and daily use of extra-virgin olive oil incorporated into all meals; moderate consumption of fish, shellfish, fermented dairy products (cheese and yoghurt), and wine (typically during meals); and a low or infrequent consumption of meat and meat products, processed cereals, sweets, vegetable oils, and butter [32,33]. As a result of its putative beneficial health effects on cardiometabolic health and healthy ageing, the MedDiet is one of the most widely evaluated dietary patterns in the scientific literature, which includes positive effects on musculoskeletal and functional outcomes in older adults [34][35][36]. Although there is less available evidence supporting this relationship in patients with T2DM, similar findings are beginning to emerge [37,38].…”

Section: Introductionmentioning

confidence: 99%

Association of Adherence to a Mediterranean Diet with Excess Body Mass, Muscle Strength and Physical Performance in Overweight or Obese Adults with or without Type 2 Diabetes: Two Cross-Sectional Studies

Buchanan

Villani

2021

Healthcare

View full text Add to dashboard Cite

Overweight and obesity in older adults is associated with disability and is exacerbated by the presence of type 2 diabetes (T2DM). There is emerging evidence that adherence to a Mediterranean diet (MedDiet) reduces adiposity and attenuates physical disability. These cross-sectional studies explored the associations of adherence to a MedDiet with body mass index (BMI), adiposity, muscle strength, and physical performance in older adults without diabetes and in middle-aged or older adults with T2DM. MedDiet adherence was assessed using the Mediterranean Diet Adherence Screener. Fat mass and percent body fat were assessed by dual energy X-ray absorptiometry. Muscle strength was assessed using hand-grip strength, while physical performance was assessed using the Short Physical Performance Battery and gait speed. A total of n = 87 participants with T2DM (T2DM sample: 71.2 ± 8.2 years, BMI: 29.5 ± 5.9) and n = 65 participants without diabetes (non-T2DM sample: 68.7 ± 5.6 years, BMI: 33.7 ± 4.9) were included in these analyses. In the T2DM sample, when controlled for age, gender, and appendicular lean mass index, adherence to a MedDiet was inversely associated with BMI, fat mass, and percent body fat. However, this was no longer maintained in the fully adjusted models. Although, adherence to a MedDiet was positively associated with gait speed (β = 0.155; p = 0.050) independent of all covariates used. Adherence to a MedDiet may be a suitable dietary strategy for preserving lower body physical function in middle-aged and older adults with T2DM. However, these findings should be further investigated using well-designed randomised controlled trials and prospective cohort studies with a wider range of adherence scores to investigate temporal associations.

show abstract

Adherence to the Mediterranean Diet and the Risk of Frailty in Old People: A Systematic Review and Meta-Analysis

Abstract: A higher adherence to Mediterranean diet is associated with a lower risk of frailty in old people. Meanwhile, the benefits may be more obvious among elders from western countries.

Cited by 80 publications

References 36 publications

Dietary Inflammatory Index and the Risk of Frailty Among Older Adults: A Systematic Review and Meta-Analysis

Dietary Inflammatory Index and the Risk of Frailty Among Older Adults: A Systematic Review and Meta-Analysis

Crosstalk Between the Gut Microbiome and Bioactive Lipids: Therapeutic Targets in Cognitive Frailty

Association of Adherence to a Mediterranean Diet with Excess Body Mass, Muscle Strength and Physical Performance in Overweight or Obese Adults with or without Type 2 Diabetes: Two Cross-Sectional Studies

Contact Info

Product

Resources

About