MicroRNA-183-5p: A New Potential Marker for Prostate Cancer

Waseem, Mohammad; Ahmad, Mohammad Kaleem; Serajuddin, Mohammad; Bhaskar, Ved; Sankhwar, Satya Narayan; Mahdi, Abbas Ali

doi:10.1007/s12291-017-0731-9

Cited by 25 publications

(11 citation statements)

References 40 publications

(43 reference statements)

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“…[6][7][8] Moreover, there has been an increased understanding on the diagnostic, prognostic, and biological functions of miRNAs in osteosarcoma patients. 9,10 As one of the vital members of the miR-183 family, miR-183-5p located on human chromosome 7 has been widely reported as an oncogene in many cancer types, such as gastric cancer, 11 hepatocellular carcinoma, prostate cancer, 12 renal cell cancer 13 and breast cancer. 14 In addition, miR-183-5p has been proposed to play a tumor suppressor role in other cancers, including lung cancer, 15 cervical cancer, 16 endometrial cancer 17 and acute myeloid leukemia.…”

Section: Introductionmentioning

confidence: 99%

MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients

Lin

Luo

Zhao

et al. 2021

CMAR

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Background Although miRNA-183-5p plays a critical role in many cancer types, including gastric cancer, hepatocellular carcinoma, prostate cancer, renal cell cancer and breast cancer, its role in osteosarcoma remains unclear. Methods Expression levels of miR-183-5p were detected in osteosarcoma tissues and cell lines using qRT-PCR. The effect of miR-183-5p on the survival and recurrence of osteosarcoma patients was analyzed in a cohort of 80 patients using Kaplan–Meier curves and Cox regression analysis. Effects of miR-183-5p on cell proliferation, migration and invasion abilities were evaluated using CCK-8, crystal violet and transwell assays. Results The expression of miR-183-5p was found to be upregulated in human osteosarcoma tissues and cell lines. Moreover, miR-183-5p expression was observed to be closely associated with tumor size, TNM stage and lung metastasis. Notably, high expression of miR-183-5p was shown to be able to predict unfavorable clinical prognosis in osteosarcoma patients. Additionally, whilst overexpression of miR-183-5p was observed to significantly promote the proliferation, migration and invasion of osteosarcoma cells; an inhibitory effect was observed with knockdown of miR-183-5p. Conclusion This study demonstrated that miR-183-5p acts as an oncogene and plays a critical role in the regulation of osteosarcoma tumor progression, and our results suggest a novel potential prognostic and therapeutic value of miR-183-5p in osteosarcoma.

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Section: Introductionmentioning

confidence: 99%

MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients

Lin

Luo

Zhao

et al. 2021

CMAR

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“…3 Some researchers have confirmed that miR-183-5p acts as a tumor promoter in some cancers, and some researchers have confirmed that it can promote cell proliferation of cancer cell lines. 4-8 The latest research shows that miR-183-5p can promote the proliferation of HCC cells by inhibiting the expression of tumor suppressors (including AKAP12, DYRK2, FOXN3, FOXO1, and LATS2). 9 However, the role of miR-183-5p in hepatocellular carcinoma is still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

miR-183-5p promotes proliferation and migration in hepatocellular carcinoma by targeting IRS1 and its association with patient survival

Yan

Yuan

et al. 2020

Int J Biol Markers

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Background: MiR-183-5p plays an important role in the pathophysiology of many tumors, while the role of MiR-183-5p in liver cancer is unclear. Methods: In this study, quantitative reverse transcription-polymerase chain reaction and Western blotting were used to detect the expression of miR-183-5p in liver cancer cell lines, liver cancer tissues, and normal tissues adjacent to the cancer, and to explore the mechanism of miR-183-5p regulating liver cancer progression. The in vitro effects of miR-183-5p were evaluated by CCK-8, colony formation test, and wound healing test. Various databases were used to predict the target mRNA of miR-183-5p and verified by luciferase report analysis. In addition, the effects of miR-183-5p and its target gene on the survival of patients with liver cancer were also analyzed. Results: miR-183-5p was highly expressed in hepatocellular carcinoma cells and tissues, and was related to some clinicopathological features. MiR-183-5p can promote the proliferation and migration of liver cancer cells. Using the bioinformatics database, we proved that miR-183-5p is related to the survival of liver cancer patients. Insulin receptor substrate 1 (IRS1) is a target of miR-183-5p, and luciferase analysis confirmed that miR-183-5p combines with the 3′-untranslated region (3′-UTR) of IRS1. Conclusion: The miR-183-5p/IRS1 axis may be a new target for liver cancer research.

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“…Another study reveals that miR-183-5p exerts a potential pancreatic cancer biomarker, and overexpression of miR-183-5p promoted cell proliferation, migration, and invasion [24]. Additionally, the promoting role of miR-183-5p in tumor cell progress has also been determined in several other cancers, such as breast cancer and prostate cancer [18,25]. In the present study, we further explored the regulatory role of miR-183-5p in the growth of VSMCs.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-183-5p acts as a potential diagnostic biomarker for atherosclerosis and regulates the growth of vascular smooth muscle cell

Sun

Shan

Sun

et al. 2019

Preprint

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Background: Atherosclerosis (AS) is a multifactorial chronic disease, and vascular smooth muscle cells (VSMCs) plays an important role in the pathology of AS. MicroRNAs regulate multiple cellular biological processes. This study aimed to investigate the clinical value of miR-183-5p in AS patients, and further explored the effects of miR-183-5p on the proliferation and migration of VSMCs.Methods: qRT-PCR was used to test the level of miR-183-5p. The diagnostic value of miR-183-5p for AS patients was assessed by a receiver operating characteristic (ROC) analysis. Cell proliferation and migration were determined via CCK-8 and Transwell assay.Results: MiR-183-5p was highly expressed in AS patients compared with the healthy group. Serum miR-183-5p expression was positively associated with CIMT and CRP in AS patients. The ROC analysis suggested that miR-183-5p had quality to be used as a biomarker with high specificity and sensitivity for AS detection. Overexpression of miR-183-5p promoted the proliferation and migration of VSMCs.Conclusion: MiR-183-5p is highly expressed in AS patients, and overexpression of miR-183-5p promots the cell proliferation and migration of VSMCs. MiR-183-5p may be a key molecular for the diagnosis and treatment of AS in the future.

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MicroRNA-183-5p: A New Potential Marker for Prostate Cancer

Cited by 25 publications

References 40 publications

MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients

MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients

miR-183-5p promotes proliferation and migration in hepatocellular carcinoma by targeting IRS1 and its association with patient survival

MicroRNA-183-5p acts as a potential diagnostic biomarker for atherosclerosis and regulates the growth of vascular smooth muscle cell

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