Anti-Helicobacter pylori xanthones of Garcinia fusca

Abstract

A new geranylated xanthone derivative, fuscaxanthone I (1), along with nine xanthones (2-9 and 11), a biphenyl (10) and three biflavonoids (12-14) were isolated from the roots of Garcinia fusca Pierre. Compounds 8, 10 and 11-14 were reported from this plant species for the first time. Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and MS. The isolated compounds were evaluated for antibacterial activity against Helicobacter pylori. Cowaxanthone (5) and fukugiside (14) exhibited stronger inhibitory activity against H. pylori DMST reference strain at MICs 4.6 and 10.8 μM, respectively, than that of the control metronidazole. Isojacareubin (8) displayed the most potent activity against H. pylori HP40 clinical isolate with MIC 23.9 μM, which was approximately two times greater than that of the standard drug amoxicillin.

Kaennacowanols A–C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa

“…Phytochemical investigation of CH 2 Cl 2 extract from the roots of G. cowa led to the isolation of three new xanthones, kaennacowanols A-C (1-3) together with nineteen known xanthones; fuscaxanthone I (4) [25], cowanol (5) [21], cowanin (6) [5], garcinone D (7) [26], α-mangostin (8) [5], pruniflorone C (9) [27], β-mangostin (10) [5], fuscaxanthone D (11) [28], fuscaxanthone C (12) [ 9-hydroxycalabaxanthone (19) [5], 5-hydroxy-8,9-dimethoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one (20) [29], fuscaxanthone A (21) [5] and jacareubin (22) [30]. The structures of these isolated xanthones were elucidated using spectroscopic methods especially 1D and 2D NMR spectroscopy.…”

Xanthones and Cancer: from Natural Sources to Mechanisms of Action

“…Branches no [78] Dihydroxyprenyl xanthone acetylated Oenothera biennis Roots no [79] Doitunggarcinone C Garcinia propinqua Twigs no [80] Dulcisxanthone H Garcinia dulcis Branches no [81] Dulcisxanthone I Garcinia dulcis Branches no [81] Dulcisxanthone J Garcinia dulcis Stem barks no [82] Dulcisxanthone K Garcinia dulcis Stem barks no [82] Dulcisxanthone L Garcinia dulcis Stem barks no [82] Epiisobractatin Garcinia bracteata Leaves yes [38] Esculentin A Garcinia esculenta Twigs no [83] Fuscaxanthone I Garcinia fusca Roots yes [84] Fuscaxanthone J Garcinia fusca Roots no [85] Fuscaxanthone K Garcinia fusca Roots no [85] Garcibractatin A Garcinia bracteata Leaves yes [86] Garcibracteatone Garcinia bracteata Leaves yes [38] Garcibractone A Garcinia bracteata Leaves yes [86] Garcibractone B Garcinia bracteata Leaves yes [86] Garcicowanone A Garcinia cowa Fruits no [87] Garcicowanone B Garcinia cowa Fruits no [87] Garciesculenxanthone A Garcinia esculenta Twigs yes [88] Garcihombronone A Garcinia hombroniana Twigs no…”

α‐Glucosidase Inhibitory Xanthones from the Roots of Garcinia fusca

“…Antibacterial activity against Helicobacter pylori of the compounds was studied. [9] As part of our continuing study on the screening of medicinal plants for a-glucosidase inhibitory activity, we found that the AcOEt extract of the roots of Garcinia fusca showed positive effect with an IC 50 value of 2.0 AE 0.4 lg/ml. Isolation was then performed and the isolated compounds were tested for the activity.…”

“…From the roots, a new xanthone named fuscaxanthone I and thirteen known compounds comprising nine xanthones, a biphenyl, and three biflavonoids, were obtained. Antibacterial activity against Helicobacter pylori of the compounds was studied . As part of our continuing study on the screening of medicinal plants for α ‐glucosidase inhibitory activity, we found that the AcOEt extract of the roots of Garcinia fusca showed positive effect with an IC 50 value of 2.0 ± 0.4 μg/ml.…”