2013
DOI: 10.1007/s12094-013-1117-y
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Abstract: Our results suggest that PRX3 is an indispensable ROS scavenger that protects tumor cells against oxidative damage and subsequent apoptosis, which provides a clue that PRX3 may be involved in the chemotherapeutic resistance of liver cancer. The underlying mechanism for PRX3 function needs further investigation.

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Cited by 23 publications
(17 citation statements)
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“…Since most of chemotherapy for cancers is through increase in ROS level and apoptotic induction of cancer cells (Srinivas et al 2004;Alexandre et al 2006;Singh et al 2007;Brown et al 2010), some researchers have suggested PRX3 to be a potential target for cancer therapy on the basis of above fact Song et al 2011). Although the overlapping peroxidatic activities of PRXs contributed to drug resistance of cancer cells (Kalinina et al 2012), PRX3 played an indispensable role in apoptotic regulation (Chua et al 2010;Li et al 2013b;Whitaker et al 2013;Wang et al 2014;McDonald et al 2014). Therefore, we have reason to look forward to the desired effects by suppressing the expression of PRX3.…”
Section: Discussionmentioning
confidence: 99%
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“…Since most of chemotherapy for cancers is through increase in ROS level and apoptotic induction of cancer cells (Srinivas et al 2004;Alexandre et al 2006;Singh et al 2007;Brown et al 2010), some researchers have suggested PRX3 to be a potential target for cancer therapy on the basis of above fact Song et al 2011). Although the overlapping peroxidatic activities of PRXs contributed to drug resistance of cancer cells (Kalinina et al 2012), PRX3 played an indispensable role in apoptotic regulation (Chua et al 2010;Li et al 2013b;Whitaker et al 2013;Wang et al 2014;McDonald et al 2014). Therefore, we have reason to look forward to the desired effects by suppressing the expression of PRX3.…”
Section: Discussionmentioning
confidence: 99%
“…By a review of substantial literature, we can draw the conclusion that the up-regulation of PRX3 in diverse cancers is involved in tumor progression or chemotherapeutic resistance through controlling ROS level and inhibiting ROS-induced apoptosis of the cancer cells (Whitaker et al 2013;Wang et al 2013Wang et al , 2014. Mitochondrion-specific PRX3 has been suggested to regulate cytochrome c release from mitochondria, which is a critical early step in the Fig.…”
Section: The Expression Of Prx3 and Its Involvement In Apoptosis Of Cmentioning
confidence: 99%
“…Having well-described antioxidant activity, PRDX family members are known for their cancer-promoting roles in HCC. PRDX1, PRDX2, and PRDX3 have been found to be overexpressed in HCC tissues, and they promote tumor progression and increase proliferation in HCC cells [14][15][16][17][18][19]. Feng et al also reported abundant expression of PRDX4 in HCC cell lines [20].…”
Section: Discussionmentioning
confidence: 99%
“…They showed that PRDX2 in the nucleus and cytoplasm distinctively regulated AR activity and is involved in the proliferation of ARexpressing prostate cancer cells and in the progression to castrationresistant prostate cancer, suggesting PRDX2 to be a key factor in prostate carcinogenesis and in the progression to castration-resistant prostate cancer (Shiota et al, 2011). PRDX2 is highly inducible by therapeutic radiation and drugs in breast cancer cells (Wang, Diaz, & Yen, 2014b;Wang, Li, Liu, Hong, & Zhang, 2014a). Several resistant tumor cells have shown upregulated PRDX2 levels in breast cancer.…”
Section: Tumor Promoting Effect Of Prdx2mentioning
confidence: 99%