Management of Dyslipidemia in Patients with Hypertension, Diabetes, and Metabolic Syndrome

Srikanth, Sundararajan; Deedwania, Prakash

doi:10.1007/s11906-016-0683-0

Cited by 53 publications

(32 citation statements)

References 63 publications

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“…Srikanth and Deedwania 46 reported that lifestyle modifications (weight loss and regular exercise) are essential components in the management of patients with MetS. Whole-body vibration exercise is a neuromuscular intervention modality used for strength training.…”

Section: Discussionmentioning

confidence: 99%

Assessment Through the Short Physical Performance Battery of the Functionality in Individuals With Metabolic Syndrome Exposed to Whole-Body Vibration Exercises

et al. 2018

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Physical activity is recommended in the management of individuals with metabolic syndrome (MetS), and recent studies have suggested whole-body vibration exercise (WBVe) for this population. The aim of this study was to evaluate the functionality through the Short Physical Performance Battery (SPPB) in individuals with MetS after WBVe. The SPPB evaluates the balance, the gait speed, and the lower limb strength (five-chair stand [5CS] test). Forty-four individuals with MetS were divided into WBVe (WBVeG) and control (CG) groups. The individuals of the WBVeG performed 10 sessions of WBVe in an oscillating/vibratory platform (OVP), barefoot, for 3 minutes at the peak-to-peak displacements of 2.5, 5.0, and 7.5 mm, with a resting period of 1 minute (total time: 18 minutes/session). The frequencies ranged from 5 up to 14 Hz. The individuals of the CG performed all the steps of the study, but the OVP was turned off. Before the first and after the tenth session, the individuals performed the SPPB. Significant responses were found in the WBVeG, analyzing the total score of the SPPB (P = .005), the balance test (P = .01), the gait speed (P = .006), and the 5CS test (P = .03), resulting in the improvement of the functionality of individuals with MetS.

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Section: Discussionmentioning

confidence: 99%

Assessment Through the Short Physical Performance Battery of the Functionality in Individuals With Metabolic Syndrome Exposed to Whole-Body Vibration Exercises

et al. 2018

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“…In other words, poor glycemic control would increase the risk of hypertriglyceridemia by 2.69% on average. This suggests an increased risk of atherogenicity due to dyslipidemia associated with poor diabetes control [25]. …”

Section: Discussionmentioning

confidence: 99%

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Naqvi

Naveed

Ali

et al. 2017

Cureus

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ContextDyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes. PurposeThe main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. This may in turn help in predicting the triglyceride status of type 2 diabetics and therefore identifying patients at increased risk from cardiovascular events. Hypertriglyceridemia is one of the common risk factors for coronary artery disease in type 2 diabetes mellitus (DM). Careful monitoring of the blood glucose level can be used to predict lipid status and can prevent most of the complications associated with the disease.MethodThis is a cross-sectional study using data collected from the outpatient diabetic clinic of Jinnah Postgraduate Medical Centre (JPMC) Karachi, Pakistan. Patients of age 18 years and above were recruited from the clinic. A total of consenting 509 patients of type 2 diabetes mellitus were enrolled over a period of 11 months. For statistical analysis, SPSS Statistics for Windows, Version 17.0 ( IBM Corp, Armonk, New York) was used and Chi-square and Pearson’s correlation coefficient was used to find the association between triglyceride and HbA1c. The HbA1c was dichotomized into four groups on the basis of cut-off. Chi-square was used for association between HbA1c with various cut-off values and high triglyceride levels. Odds-ratio and its 95% confidence interval were calculated to estimate the level of risk between high triglyceride levels and HbA1c groups. The p-value < 0.05 was considered statistically significant for all the tests applied for significance.ResultThe association of high triglyceride was evaluated in four different groups of HbA1c, with a cut-off seven, eight, nine and 10 respectively. With HbA1c cut-off value of 7%, 74% patients had high triglycerides and showed a significant association with high triglyceride levels at p < 0.001 and odds ratio was 2.038 (95% confidence interval: 1.397 – 2.972). Logistic regression models were adjusted for demographic factors (age, race, gender), lifestyle factors (smoking, body mass index, lifestyle) and health status factors (blood pressure, physician-rated health status).ConclusionAfter adjusting for relevant covariates, glycated hemoglobin was positively correlated with high triglyceride. Hence, HbA1c can be an indicator of triglyceride level and can be one of the predictors of cardiovascular risk factors in type 2 diabetes mellitus.

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“…Statins are HMG‐CoA reductase inhibitors that are extensively used in both primary and secondary prevention of cardiovascular disease due to their effective plasma lipid‐lowering abilities . Dyslipidemia is a common feature of both the metabolic syndrome and NAFLD, placing patients at increased risk of cardiovascular events . Moreover, NAFLD alone is an independent risk factor for cardiovascular disease.…”

Section: Pharmaco‐therapeutic Options In Nashmentioning

confidence: 99%

“…49 Dyslipidemiaisacommonfeatureofboththemetabolicsyndromeand NAFLD,placingpatientsatincreasedriskofcardiovascularevents. 50,51 Moreover,NAFLDaloneisanindependentriskfactorforcardiovascular disease. However, statins have been found to be underused forthiscondition,althoughtheyareconsideredtobegenerallysafe atmoderatedosesinpatientswithchronicliverdisease.…”

Section: Lipid-altering Agentsmentioning

confidence: 99%

Therapies in non‐alcoholic steatohepatitis (NASH)

Oseini

Sanyal

2017

Liver International

200

170

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The hallmark of non-alcoholic fatty liver disease (NAFLD) is excessive fatty accumulation in the hepatocytes, which may be an isolated event (non-alcoholic fatty liver, NAFL) or accompanied by evidence of inflammation and cell injury with or without fibrosis (non-alcoholic steatohepatitis, NASH). NASH, the more aggressive form of NAFLD, may progress to cirrhosis and hepatocellular carcinoma. Because it has been estimated that NASH will overtake hepatitis C virus infection as the leading cause of liver transplantation in the US in the coming decade, and there are no current FDA-approved therapies for this disease, the need to find appropriate therapeutic targets is now more urgent than ever before. Diet and other life-style modifications have always been difficult to maintain and this approach alone has not slowed the rising tide of the disease. While the results of traditional therapies such as vitamin E and pioglitazone have been significant for steatosis and inflammation, they have had no effect on fibrosis, which is the strongest indicator of mortality in this condition. However, the understanding of the pathogenesis and progression of NASH has evolved and several promising novel therapies to target and possibly reverse fibrosis are being evaluated, making the future outlook of NASH therapy more optimistic.

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Management of Dyslipidemia in Patients with Hypertension, Diabetes, and Metabolic Syndrome

Cited by 53 publications

References 63 publications

Assessment Through the Short Physical Performance Battery of the Functionality in Individuals With Metabolic Syndrome Exposed to Whole-Body Vibration Exercises

Assessment Through the Short Physical Performance Battery of the Functionality in Individuals With Metabolic Syndrome Exposed to Whole-Body Vibration Exercises

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Therapies in non‐alcoholic steatohepatitis (NASH)

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