2005
DOI: 10.1007/s11883-005-0040-2
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Abstract: Complications of vulnerable atherosclerotic plaques (rupture, luminal and mural thrombosis, intraplaque hemorrhage, rapid progression to stenosis, spasm, and so forth) lead to heart attacks and strokes. It remains difficult to identify what plaques are vulnerable to these complications. Despite recent developments such as thermography, spectroscopy, and magnetic resonance imaging, none of them is approved for clinical use. Intravascular ultrasound (IVUS), a relatively old yet widely available clinical tool for… Show more

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Cited by 105 publications
(65 citation statements)
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“…In the final phase, the plaque is enveloped in luxurious adventitial vasa vasorum and intraplaque neovascularization, a hallmark of symptomatic atherosclerosis. 11 For these reasons, plaque remodeling has been the target of medical therapies, such as statins, aiming at the possibility of transforming an unstable plaque into a more stable plaque, reducing the cerebrovascular risk. 12 In our patients, studied with ultrasound contrast pulse sequencing and SonoVue, we observed that UCA penetrates easily in the fibrous and fatty tissue and, according to our histological findings and to recent observations, 4,13 it is related to the plaque vascularization.…”
Section: Discussionmentioning
confidence: 99%
“…In the final phase, the plaque is enveloped in luxurious adventitial vasa vasorum and intraplaque neovascularization, a hallmark of symptomatic atherosclerosis. 11 For these reasons, plaque remodeling has been the target of medical therapies, such as statins, aiming at the possibility of transforming an unstable plaque into a more stable plaque, reducing the cerebrovascular risk. 12 In our patients, studied with ultrasound contrast pulse sequencing and SonoVue, we observed that UCA penetrates easily in the fibrous and fatty tissue and, according to our histological findings and to recent observations, 4,13 it is related to the plaque vascularization.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, contrast-enhanced ultrasound (microbubbles) provides high-quality images of human plaque microvessels in carotid lesions 70 and may also facilitate imaging neovessels in coronary lesions. 71 Despite these preliminary results, multiple limitations of each of these techniques oriented the field toward molecular imaging. 72 As a general principle, molecular imaging of angiogenesis targets the endothelial cell.…”
Section: Neovascularization and Imagingmentioning
confidence: 99%
“…A preliminary human study using conventional IVUS systems with a clinically available contrast agent demonstrated the feasibility of tracking the distribution of and dynamic changes in echo density within the coronary plaque and adventitial region after intracoronary microbubble injection. 81 One technical challenge is the detection and monitoring of relatively weak contrast signals on the background vessel wall structure. The above initial study relied on the digital processing of gray-scale, phase-correlated IVUS images.…”
Section: Vasa Vasorum Imagingmentioning
confidence: 99%