Effects of paracetamol on the polychaete Hediste diversicolor: occurrence of oxidative stress, cyclooxygenase inhibition and behavioural alterations

Nogueira, Ana Filipa; Nunes, Bruno

doi:10.1007/s11356-020-12046-7

Cited by 9 publications

(2 citation statements)

References 99 publications

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“…In this case, microscopic analysis of cells reflects a remarkable decrease in MI, reaching a maximum of 9 ± 0.7 and 9.8 ± 1.2 at 500 mg L −1 treatment in P. sativum and L. culinaris , respectively. According to several investigations using eukaryotic models as bioindicators, e.g., Hediste diversicolor (Nogueira and Nunes 2021 ), Hyalella azteca (Gómez-Oliván et al 2012 ), Daphnia magna (Daniel et al 2019 ), Crassostrea gigas (Bebianno et al 2017 ), Dreissena polymorpha (Parolini et al 2010 ), Gibbula umbilicalis (Giménez and Nunes 2019 ), Phorcus lineatus (Almeida and Nunes 2019 ), Ruditapes philippinarum (Correia et al 2016 ), Mytilus spp. (Piedade et al 2020 ), Rhamdia quelen (Perussolo et al 2019 ), Cyprinus carpio (Gutiérrez-noya et al 2020 ), Danio rerio (Xia et al 2017 ), Chlorella sp .…”

Section: Resultsmentioning

confidence: 99%

Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L

Mercado

Galvis

2023

Environ Sci Pollut Res

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Paracetamol is one of the most widely used drugs worldwide, yet its environmental presence and hazardous impact on non-target organisms could rapidly increase. In this study, the possible cytotoxic effects of paracetamol were evaluated using two bioindicator plants Lens culinaris and Pisum sativum . Concentrations of 500, 400, 300, 200, 100, 50, 25, 5, 1 mg L −1 , and a control (distilled water) were used for a total of 10 treatments, which were subsequently applied on seeds of Lens culinaris Med . and Pisum sativum L. ; after 72 h of exposure, root growth, mitotic index, percentage of chromosomal abnormalities, and the presence of micronucleus were evaluated. The cytotoxic effect of paracetamol on L. culinaris and P. sativum was demonstrated, reporting the inhibition of root growth, the presence of abnormalities, and a significant micronucleus index at all concentrations used, which shows that this drug has a high degree of toxicity.

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Section: Resultsmentioning

confidence: 99%

Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L

Mercado

Galvis

2023

Environ Sci Pollut Res

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“…For example, antineoplastic drugs used against cancer diseases are responsible to cause changes in the reproductive function, oxidative stress, genotoxicity, cytotoxicity and neurotoxicity [56]. Widely used analgesics (e.g., paracetamol) are systematically reported to occur in the wild, where they may exert effects on oxidative stress biomarkers [57][58][59].…”

Section: Environmental Impact and Risk Assessmentmentioning

confidence: 99%

Emerging Contaminants in Seafront Zones. Environmental Impact and Analytical Approaches

et al. 2021

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Some chemical substances have the potential to enter the coastal and marine environment and cause adverse effects on ecosystems, biodiversity and human health. For a large majority of them, their fate and effects are poorly understood as well as their use still unregulated. Finding effective and sustainable strategies for the identification of these emerging and/or anthropogenic contaminants that might cause polluting effects in marine environments to mitigate their adverse effects, is of utmost importance and a great challenge for managers, regulators and researchers. In this review we will evaluate the impact of emerging contaminants (ECs) on marine coastal zones namely in their ecosystems and biodiversity, highlighting the potential risks of organic pollutants, pharmaceuticals and personal care products. Emerging microextraction techniques and high-resolution analytical platforms used in isolation, identification and quantification of ECs will be also reviewed.

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A multi-biomarker approach for the early assessment of the toxicity of hospital wastewater using the freshwater organism Daphnia magna

Afsa

Vieira

Nogueira

et al. 2021

Environ Sci Pollut Res

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Effects of paracetamol on the polychaete Hediste diversicolor: occurrence of oxidative stress, cyclooxygenase inhibition and behavioural alterations

Cited by 9 publications

References 99 publications

Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L

Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L

Emerging Contaminants in Seafront Zones. Environmental Impact and Analytical Approaches

A multi-biomarker approach for the early assessment of the toxicity of hospital wastewater using the freshwater organism Daphnia magna

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