Sequence-specific nucleases as tools for enhancing disease resistance in crops

Nekrasov, Vladimir

doi:10.1007/s11248-019-00137-2

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…The resistance through S genes has so far followed the loss of function of the gene (product) and thus prevents exploitation by the pathogen in the long term. The loss of the gene product in the entire development process of the plant can, but does not have to, lead to losses in terms of crop yields of the respective plant species or variety [144]. One way to circumvent this yield loss can be to prevent the pathogen-specific exploitation of the gene by modifying the corresponding areas of the promoter, demonstrated in rice for the Xanthomonas oryzae pv.…”

Section: Changes Altering Pathogen Resistance Implemented With the Help Of Ngtmentioning

confidence: 99%

Genome Editing in Crop Plant Research—Alignment of Expectations and Current Developments

Hüdig

Laibach

Hein

2022

Plants

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The rapid development of genome editing and other new genomic techniques (NGT) has evoked manifold expectations on purposes of the application of these techniques to crop plants. In this study, we identify and align these expectations with current scientific development. We apply a semi-quantitative text analysis approach on political, economic, and scientific opinion papers to disentangle and extract expectations towards the application of NGT-based plants. Using the sustainable development goals (SDG) of the 2030 agenda as categories, we identify contributions to food security or adaptation to climatic changes as the most frequently mentioned expectations, accompanied by the notion of sustainable agriculture and food systems. We then link SDG with relevant plant traits and review existing research and commercial field trials for genome-edited crop plants. For a detailed analysis we pick as representative traits drought tolerance and resistance against fungal pathogens. Diverse genetic setscrews for both traits have been identified, modified, and tested under laboratory conditions, although there are only a few in the field. All in all, NGT-plants that can withstand more than one stressor or different environments are not documented in advanced development states. We further conclude that developing new plants with modified traits will not be sufficient to reach food security or adaption to climatic changes in a short time frame. Further scientific development of sustainable agricultural systems will need to play an important role to tackle SDG challenges, as well.

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Section: Changes Altering Pathogen Resistance Implemented With the Help Of Ngtmentioning

confidence: 99%

Genome Editing in Crop Plant Research—Alignment of Expectations and Current Developments

Hüdig

Laibach

Hein

2022

Plants

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“…Vladimir Nekrasov from the Plant Sciences Department at Rothamsted Research, the United Kingdom, provided the fifth contribution to the topic of “Applications of genome editing in crops”; in his presentation entitled “Genome editing as a tool for enhancing disease resistance in crops”, (Nekrasov 2019), he reminded the audience that the MIT Technology Review had voted the CRISPR genome editing technology one of the 10 breakthrough technologies in 2016 7. “By now,” Nekrasov added, “the technology has been applied in some model plants (incl.…”

Section: Session 1: Applications Of Genome Editing In Agriculturementioning

confidence: 99%

Meeting report of the OECD conference on “Genome Editing: Applications in Agriculture—Implications for Health, Environment and Regulation”

Friedrichs¹,

Takasu

Kearns

et al. 2019

Transgenic Res

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The “OECD Conference on Genome Editing: Applications in Agriculture—Implications for Health, Environment and Regulation” was held on the 28–29 June 2018 at the OECD headquarter and conference centre in Paris, France. It brought together policy makers, academia, innovators and other stakeholders involved in the topic, in order to take stock of the current technical developments and implementations of genome editing, as well as their applications in various areas of agriculture and the implications they give rise to (More information on the “OECD Conference on Genome Editing: Applications in Agriculture—Implications for Health, Environment and Regulation” can be found on the OECD Genome Editing hub: http://www.oecd.org/environment/genome-editing-agriculture/ ; the hub also contains the detailed conference programme, the biographies of all conference speakers, the detailed conference abstracts, and the presentations of the two-day conference). The conference aimed to provide a clearer understanding of the regulatory considerations raised by products of genome editing, pointing towards a coherent policy approach to facilitate innovations involving genome editing.

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CRISPR/Cas9 and Cas13a systems: a promising tool for plant breeding and plant defence

Badar

Venkataraman

Hefferon

2021

CRISPR and RNAi Systems

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Sequence-specific nucleases as tools for enhancing disease resistance in crops

Cited by 4 publications

References 30 publications

Genome Editing in Crop Plant Research—Alignment of Expectations and Current Developments

Genome Editing in Crop Plant Research—Alignment of Expectations and Current Developments

Meeting report of the OECD conference on “Genome Editing: Applications in Agriculture—Implications for Health, Environment and Regulation”

CRISPR/Cas9 and Cas13a systems: a promising tool for plant breeding and plant defence

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