2019
DOI: 10.1007/s11154-019-09513-z
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Abstract: There is now a wealth of evidence showing that communication between microbiota and the host is critical to sustain the vital functions of the healthy host, and disruptions of this homeostatic coexistence are known to be associated with a range of diseases including obesity and type 2 diabetes. Microbiota-derived metabolites act both as nutrients and as messenger molecules and can signal to distant organs in the body to shape host pathophysiology. In this review, we provide a new perspective on succinate as a … Show more

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Cited by 166 publications
(119 citation statements)
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References 97 publications
(112 reference statements)
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“…This genus is characterized by the production of succinic acid [ 100 ], which can be associated with microbiome dysbiosis and intestinal inflammation [ 101 ]. Normally, succinate is detected at low concentrations in the gut lumen because of its rapid conversion into propionate; however, several studies found a higher concentration of succinate in IBD patients [ 102 ], and an association between succinate accumulation in the gut lumen and microbiota disturbances has recently emerged [ 101 , 103 ]. Here, we have to emphasize that Odoribacter is a succinate-consuming bacterium, and its increased abundance may be theoretically related to Paraprevotella succinate production.…”
Section: Discussionmentioning
confidence: 99%
“…This genus is characterized by the production of succinic acid [ 100 ], which can be associated with microbiome dysbiosis and intestinal inflammation [ 101 ]. Normally, succinate is detected at low concentrations in the gut lumen because of its rapid conversion into propionate; however, several studies found a higher concentration of succinate in IBD patients [ 102 ], and an association between succinate accumulation in the gut lumen and microbiota disturbances has recently emerged [ 101 , 103 ]. Here, we have to emphasize that Odoribacter is a succinate-consuming bacterium, and its increased abundance may be theoretically related to Paraprevotella succinate production.…”
Section: Discussionmentioning
confidence: 99%
“…These include succinate and lactate, both of which are present in saliva. Succinate is traditionally considered a citric-acid cycle intermediate although recently evidence is emerging to support its role as regulator of gluconeogenesis as well as having anti-inflammatory effects [114]. Lactate has similarly been long considered a metabolic waste product, although evidence for diverse physiological functions is emerging including immune regulation, anti-inflammatory properties and maintenance of epithelial barriers [115].…”
Section: Potential Physiological Significance Of Salivary Metabolitesmentioning
confidence: 99%
“…Among the human gut microbiota, the genus Bacteroides produces acetate and succinate as the main metabolites, so that a symbiotic relationship based on succinate is conceivable. Excess accumulation in the intestine of succinate induces diarrhea (Fernández‐Veledo & Vendrell, 2019; Ferreyra et al, 2014), and the presence of succinate‐utilizing bacteria may have beneficial effects on humans. Bacteroides thetaiotaomicron commonly inhabits the human gut and is capable of digesting polysaccharides (Flint, Bayer, Rincon, Lamed, & White, 2008; Porter, Luis, & Martens, 2018; Xu et al, 2003).…”
Section: Introductionmentioning
confidence: 99%