Utilization of Chemically Synthesized Super Paramagnetic Iron Oxide Nanoparticles in Drug Delivery, Imaging and Heavy Metal Removal

Sruthi, P Durga; Sahithya, Chamarthy Sai; Justin, C.; C, SaiPriya; Bhavya, Karanam Sai; Senthilkumar, P.; Samrot, Antony V.

doi:10.1007/s10876-018-1454-7

Cited by 22 publications

(14 citation statements)

References 46 publications

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“…Polysaccharides can be used as nanocarrier to carry drugs, which is possible when the polysaccharides are carboxymethylated and chelated with an appropriate chelator like STMP (sodium tri metaphosphate), STPP (sodium tripolyphosphate) etc , Samrot et al 2018a, Shobana et al 2019. These polysaccharide nanocarriers have attracted attention of various researchers in the field of medical field for drug delivery and drug encapsulation (Justin et al 2017, Justin et al 2018, Sruthi et al 2019. This is mainly because particles at smaller size exhibits wide range of properties than the bulk material.…”

Section: Introductionmentioning

confidence: 99%

Purification, characterization and exploitation of Azadirachta indica gum for the production of drug loaded nanocarrier

Samrot

Angalene

Roshini

et al. 2020

Mater. Res. Express

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In this study, gum polysaccharide of Azadirachta indica was extracted and purified. The obtained polysaccharide was subjected to TLC chromatography, spectroscopic analysis, thermogravimetric analysis and GC-MS analysis. The polysaccharide was found to have Glucose, Idosan, Allose, Galactose, Ribose and Xylose. The polysaccharide was not having antibacterial activity but possessed good antioxidant and anticancer activity. The extracted polysaccharide was further carboxymethylated and used for the synthesis of nanocarrier to carry anticancer drug, curcumin. Size of the drug unloaded nanocarrier were found to be size below 40 nm, whereas the drug loaded nanocarriers were around 50 to 70 nm. The nanocarriers were studied for cytotoxicity against MCF7 cancer cell line and found to be effective.

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Section: Introductionmentioning

confidence: 99%

Purification, characterization and exploitation of Azadirachta indica gum for the production of drug loaded nanocarrier

Samrot

Angalene

Roshini

et al. 2020

Mater. Res. Express

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“…1,2 Their surface area interaction of these nanoparticles leads to unique properties 3,4 and it can be applied in electronics, biomedicine, imaging, environmental remediation etc. [5][6][7][8][9][10] In nanobiotechnology, the recent decade has recorded extensive research on formulation of nanocarriers since they promote easy transport and availability of drug molecules to the targeted site. Nanocarriers are being formulated from both inorganic and organic resources.…”

Section: Introductionmentioning

confidence: 99%

“…11 They include metal nanoparticles like gold, silica, silver and magnetic iron oxide nanoparticles. 5,12,13 But the use of these metal nanoparticles as drug carriers can pose a threat of metal poisoning within the system. Some of the organically derived nanocarriers like polymeric micelles, liposomes, chitosan-based nanocarriers and polymeric nanogels are good for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Extraction, Purification, and Characterization of Polysaccharides of Araucaria heterophylla L and Prosopis chilensis L and Utilization of Polysaccharides in Nanocarrier Synthesis

Samrot¹,

Kudaiyappan²,

Bisyarah³

et al. 2020

IJN

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Background: Plant gums consist of polysaccharides which can be used in the preparation of nanocarriers and provide a wide application in pharmaceutical applications including as drug delivery agents and the matrices for drug release. The objectives of the study were to collect plant gums from Araucaria heterophylla L and Prosopis chilensis L and to extract and characterize their polysaccharides. Then to utilize these plant gum-derived polysaccharides for the formulation of nanocarriers to use for drug loading and to examine their purpose in drug delivery in vitro. Methods: Plant gum was collected, polysaccharide was extracted, purified, characterized using UV-Vis, FTIR, TGA and GCMS and subjected to various bioactive studies. The purified polysaccharide was used for making curcumin-loaded nanocarriers using STMP (sodium trimetaphosphate). Bioactivities were performed on the crude, purified and drugloaded nanocarriers. These polysaccharide-based nanocarriers were characterized using UV-Vis spectrophotometer, FTIR, SEM, and AFM. Drug release kinetics were performed for the drug-loaded nanocarriers. Results: The presence of glucose, xylose and sucrose was studied from the UV-Vis and GCMS analysis. Purified polysaccharides of both the plants showed antioxidant activity and also antibacterial activity against Bacillus sp. Purified polysaccharides were used for nanocarrier synthesis, where the size and shape of the nanocarriers were studied using SEM analysis and AFM analysis. The size of the drug-loaded nanocarriers was found to be around 200 nm. The curcumin-loaded nanocarriers were releasing curcumin slow and steady. Conclusion: The extracted pure polysaccharide of A. heterophylla and P. chilensis acted as good antioxidants and showed antibacterial activity against Bacillus sp. These polysaccharides were fabricated into curcumin-loaded nanocarriers whose size was below 200 nm. Both the drug-loaded nanocarriers synthesized using A. heterophylla and P. chilensis showed antibacterial activity with a steady drug release profile. Hence, these natural exudates can serve as biodegradable nanocarriers in drug delivery.

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“…As a part of therapeutics, these particles used for targeted drug delivery could reduce the concentration of drug required and also enhance the potency of drug. Some metals are known to have side effects, but can be ruled out when proper nanoparticle is chosen as drug carrier, one such is SPIONs (superparamagnetic iron oxide nanoparticles), which is known for its biocompatibility, even it can modified to aid the tagging of any drug/ ligand / molecule/ protein and helps in targeted delivery to desired site [8][9][10][11] . These SPIONs can be moved or brought to target location by controlled external magnetic movement.…”

Section: Introductionmentioning

confidence: 99%

“…Reports are there for using these SPIONs in targeted drug delivery in vivo as well as invitro [11][12][13][14] . Moreover, these kind of SPIONs have been used to deliver antibiotics against bacteria 8,10 . Functionalization also gives stability to it 11,15 .…”

Section: Introductionmentioning

confidence: 99%

Production and Utilization of SPIONs for In-vitro Drug Release and X-ray Imaging

Samrot¹,

C²,

Sruthi³

et al. 2020

J Pure Appl Microbiol

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In this study, SPIONs were produced in the presence of cobalt as catalyst. SPIONs formed by this chemical co-precipitation were size around 20 nm. After producing the SPIONs, it was subjected for functionalization with oleic acid and loaded with drug-itraconazole (a drug possess antifungal and antibacterial activity) and encapsulated with polyhydroxybutyrate (PHB). The produced core-shell SPIONS was used for antimicrobial study against two bacteria namely-Pseudomonas aeruginosa and Brevibacillus brevis and a fungi-Candida albicans. It was found to be effectively releasing drug for more than 3 hours. The SPIONs alone was acting good as contrasting agent and used for enhancing X-ray imaging.

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Utilization of Chemically Synthesized Super Paramagnetic Iron Oxide Nanoparticles in Drug Delivery, Imaging and Heavy Metal Removal

Cited by 22 publications

References 46 publications

Purification, characterization and exploitation of Azadirachta indica gum for the production of drug loaded nanocarrier

Purification, characterization and exploitation of Azadirachta indica gum for the production of drug loaded nanocarrier

<p>Extraction, Purification, and Characterization of Polysaccharides of <em>Araucaria heterophylla</em> L and <em>Prosopis chilensis</em> L and Utilization of Polysaccharides in Nanocarrier Synthesis</p>

Production and Utilization of SPIONs for In-vitro Drug Release and X-ray Imaging

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