Carbon quantum dots: synthesis, characterization, and assessment of cytocompatibility

Zhang, Zhengwei; Duan, Yu; Yu, Yan; Yan, Zhengyu; Chen, Jianqiu

doi:10.1007/s10856-015-5536-x

Cited by 21 publications

(9 citation statements)

References 31 publications

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“…This allowed us to shed more light on the cytotoxicity issue. The existing literature data that have been reported differ considerably in cell lines used, concentrations, and incubation times [ 4 , 34 , 38 , 39 ]. It has been suggested by other researchers that carbon dots toxicity and cellular internalization may vary in different cell types, which is underpinned by various mechanisms of uptake and intracellular processing [ 7 , 8 , 39 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Protein Corona Hinders N-CQDs Oxidative Potential and Favors Their Application as Nanobiocatalytic System

Czarnecka

Kwiatkowski

Wiśniewski

et al. 2021

IJMS

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The oxidative properties of nanomaterials arouse legitimate concerns about oxidative damage in biological systems. On the other hand, the undisputable benefits of nanomaterials promote them for biomedical applications; thus, the strategies to reduce oxidative potential are urgently needed. We aimed at analysis of nitrogen-containing carbon quantum dots (N-CQDs) in terms of their biocompatibility and internalization by different cells. Surprisingly, N-CQD uptake does not contribute to the increased oxidative stress inside cells and lacks cytotoxic influence even at high concentrations, primarily through protein corona formation. We proved experimentally that the protein coating effectively limits the oxidative capacity of N-CQDs. Thus, N-CQDs served as an immobilization support for three different enzymes with the potential to be used as therapeutics. Various kinetic parameters of immobilized enzymes were analyzed. Regardless of the enzyme structure and type of reaction catalyzed, adsorption on the nanocarrier resulted in increased catalytic efficiency. The enzymatic-protein-to-nanomaterial ratio is the pivotal factor determining the course of kinetic parameter changes that can be tailored for enzyme application. We conclude that the above properties of N-CQDs make them an ideal support for enzymatic drugs required for multiple biomedical applications, including personalized medical therapies.

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Section: Discussionmentioning

confidence: 99%

Protein Corona Hinders N-CQDs Oxidative Potential and Favors Their Application as Nanobiocatalytic System

Czarnecka

Kwiatkowski

Wiśniewski

et al. 2021

IJMS

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“…Studies related to cytotoxicity of C-dots have been conducted by different scientists, organizations, and institutes, but only a few results and reports are present right now. Zhang et al 18 investigated the cytotoxicity of carbon QDs on rat mesangial cells. No apparent cytotoxicity and much better biosafety properties of C-dots were reported for biologic fluorescent probe applications.…”

Section: Cytotoxicitymentioning

confidence: 99%

Carbon Quantum Dots: Synthesis, Characterization and Biomedical Applications

Singh

Arora

Dhiman

et al. 2018

tjps

106

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ÖZ INTRODUCTIONLuminescent semiconductor nano crystals of size 1-10 nanometers with rich surface chemistry and unique optical properties are called quantum dots (QDs). Different compounds belonging to group 2 to 4 and 3 to 5, e.g., Ag, Cd, Zn, Hg, Se, Ln, Pb, P, and Te lead to the formation of QDs. These have become an obligatory tool for traceable targeted delivery, biomedical research, and different therapy applications. Longterm fluorescence imaging and the detection of the properties of these nanoparticles (NPs) have made them imperative in biomedical research. Different properties of QDs such as resistance to photobleaching, superior signal brightness, larger absorption coefficients, light emission, and contemporaneous excitation of different fluorescence colors make them unique, as well as indispensable. Advances in quantum surface chemistry studies have led to the development of polymer-encapsulated probes with high fluorescence properties that are stable under complex biologic conditions. To use QDs in biologic studies, it is extremely important to cap or passivate the ZnS or CdS layer around the QD (CdSe). This layering of ZnS or CdS leads to the improvement of the fluorescence quantum yield (QY) of QDs and provides protection against photo-oxidation. QDs have had a major impact in molecular diagnostics and in tissue molecular KKN, ayırt edici özellik olarak, 10 nm'den daha küçük boyutu olan, küçük karbon nanopartiküllerdir ve izlenebilir hedeflenmiş salım, biyomedikal araştırma ve farklı terapi uygulamaları için zorunlu bir araç haline gelmiştir. Bu çalışmanın amacı, KKN'nın sentezi, karakterizasyon teknikleri ve biyomedikal uygulamaları ile ilgili güncel literatürü bir araya getirmekti. KKN sentezi için iki tip yapay yöntem yani yukarıdan aşağıya yaklaşım ve aşağıdan yukarıya yaklaşım kullanıldı. Yukarıdan aşağıya doğru yaklaşım, ark boşaltma yöntemini, lazer ablasyon yöntemini ve elektrokimyasal yöntemi içermektedir. Öte yandan aşağıdan yukarı yaklaşım, termal yöntem, mikrodalga destekli yöntem, hidrotermal ve sulu yöntem ve kalıp yöntemini içerir. Bu derlemede, CQD'nin biyomedikal alanda son dönemdeki ilerlemesini, sentetik yöntemlerine, karakterizasyonuna ve farklı uygulamalara odaklanarak açıkladık. Karbon noktaları, in vivo ve in vitro biyolojik görüntüleme ve etken madde salım çalışmaları için kapsamlı yeterliliğe sahiptir. Karbon noktaları için daha fazla sitotoksisite araştırması yapılmasına ihtiyaç duyulmasına rağmen, önceki veriler etken madde salımı ve biyolojik görüntüleme çalışmalarında karbon noktalarının parlak geleceğini göstermektedir. Anahtar kelimeler: Karbon kuantum noktalar, nanopartiküller, kuantum verimi, karbon nokta, fotolüminesans, nanokompozitler CQD are small carbon nanoparticles smallerl than 10 nm comprising distinctive properties, which have become an obligatory tool for traceable targeted delivery, biomedical research, and different therapy applications. The objective of the present work was to consolidate the current literature on the synthesis, characterizati...

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“…61 CDs have excellent water solubility 62 and are more environmentally friendly and much safer for biological use than most traditional quantum dots and heavy metal ions. 63,64 It was shown that after intravenous injection, 35 nm CDs accumulate in the reticuloendothelial system and kidney, and then they are gradually excreted both renally and fecally. A dose of 20 mg kg À1 appears safe to use in experimental animals over a period of 3 months.…”

Section: Bubbles As a Reliable Marker Of The Opening Of Individual MImentioning

confidence: 99%

Carbon dot aggregates as an alternative to gold nanoparticles for the laser-induced opening of microchamber arrays

et al. 2018

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Carbon quantum dots: synthesis, characterization, and assessment of cytocompatibility

Cited by 21 publications

References 31 publications

Protein Corona Hinders N-CQDs Oxidative Potential and Favors Their Application as Nanobiocatalytic System

Protein Corona Hinders N-CQDs Oxidative Potential and Favors Their Application as Nanobiocatalytic System

Carbon Quantum Dots: Synthesis, Characterization and Biomedical Applications

Carbon dot aggregates as an alternative to gold nanoparticles for the laser-induced opening of microchamber arrays

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