“…The development of nanotechnology has led to revolutionary achievements in diagnosis, therapy, catalysts, sensors, and electronic devices. − Wrapped nanoparticles (NPs) could be developed into novel structures, such as core–shell, yolk–shell, and hollow materials, with large surface areas absorbing to substrates or storing molecules. − Recent studies have revealed that core–shell nanocomposites show advantageous characteristics like a high theoretical specific surface area ( S BET ), easy size tuning, and excellent formability into various shapes. − Particle size and shape are important factors that determine the applicability of NPs. − Among the various types of core–shell NPs available today, nanoflowers have received wide attention due to their variety of 3D structures and large surface area. , Nanoflower-like core–shell structures could be effectively employed in drug delivery, cell imaging, biosensors, and other biomedical applications because their size and shape can easily be controlled. − , Various metal oxide nanoflowers, such as CuO, TiO 2 , ZnO, NiO, and B i2 MoO 6 , have been actively studied to detect industrially produced volatile organic compounds and toxic gases because of their high selectivity. − NiO nanoflowers present good responses toward NO 2 , which is derived from their flower-like structure, mesoporous pores, and large surface area. Such nanoflowers can also exhibit excellent responses to NO 2 even at very low concentrations. , A sensor composed of Bi 2 MoO 6 demonstrated good sensitivity toward NO, which rapidly and linearly increased with increasing NO concentration.…”