Development of biocompatible fluorescent gelatin nanocarriers for cell imaging and anticancer drug targeting

Nezhad‐Mokhtari, Parinaz; Arsalani, Nasser; Ghorbani, Marjan; Hamishehkar, Hamed

doi:10.1007/s10853-018-2371-8

Cited by 57 publications

(24 citation statements)

References 47 publications

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“…After 3 hours, the coverslips were placed onto the glass microscope slides, and the photographs were saved using a fluorescence microscopy (Olympus, Bh2‐RFCA, Japan). To observe the uptake of MTX‐CDs@NGs by A549 and MCF7, rhodamine was conjugated into the NGs with previously reported method . To investigate the effectiveness of the NGs as drug carriers, the seeded cells were treated with rhodamine‐labeled CDs@NGs for 0.5 and 2 hours.…”

Section: Methodsmentioning

confidence: 99%

“…To observe the uptake of MTX-CDs@NGs by A549 and MCF7, rhodamine was conjugated into the NGs with previously reported method. 12 To investigate the effectiveness of the NGs as drug carriers, the seeded cells were treated with rhodamine-labeled CDs@NGs for 0.5 and 2 hours. Then cells were washed with PBS (pH 7.4) three times, and the uptake of rhodamine dye was obtained using a FACSCalibur flow cytometer (Becton-Dickinson Immunocytometry Systems, San Jose, California).…”

Section: In Vitro Cell Imaging and Cell Uptake Studiesmentioning

confidence: 99%

“…Additionally, one of the current standards of care for many solid tumors includes imaging. In this context, nanoscaled quantum dots (QDs) with unique optical properties have been used for the development of imaging . Therefore, the composite of fluorescent nanodots/NGs presented applications in bio‐imaging and drug delivery .…”

Section: Introductionmentioning

confidence: 99%

“…In this context, nanoscaled quantum dots (QDs) with unique optical properties have been used for the development of imaging. 12 Therefore, the composite of fluorescent nanodots/NGs presented applications in bio-imaging and drug delivery. 13 However, because of severe toxicity of metal dots (QDs) and the release of cytotoxic metals into the biological environment, the in vivo applications of QDs may hold back, which could damage normal cells.…”

Section: Introductionmentioning

confidence: 99%

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Glutathione and pH‐responsive fluorescent nanogels for cell imaging and targeted methotrexate delivery

Ghorbani

Mahmoodzadeh

Jannat

et al. 2019

Polymers for Advanced Techs

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Cancer is one of the health problems that lead to death in the world, and nanotechnology was shown to have a unique potential to improve the therapeutic efficacy of anticancer agents. The nanosized drug delivery systems (DDSs) have been offered for targeting tumor tissue because of enhanced drug bioavailability and long circulation time. In this context, we reported a facial approach to prepare a novel pH and glutathione‐responsive nanogel. After that, the nanocarriers coupled with highly fluorescent quantum dots were developed. Then methotrexate (MTX) was loaded into and on the surface of nanogels by ionic interaction so that the triggered MTX release ability of the synthesized nanocarriers was verified through the assessment of in vitro drug release at simulated tumor tissue condition. The improved efficiency of the developed nanogels and their targeted performance via conjugation of MTX (as target ligand of folate receptors) were investigated through the various cell cytotoxicity studies such as 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay, 4′6‐diamidino‐2‐phenylindole (DAPI) staining, and flow cytometry. The results of various cell cytotoxicity studies concluded that the developed smart nanogels have many promising abilities for the targeted MTX delivery to cancer tissues.

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Section: Methodsmentioning

confidence: 99%

Section: In Vitro Cell Imaging and Cell Uptake Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glutathione and pH‐responsive fluorescent nanogels for cell imaging and targeted methotrexate delivery

Ghorbani

Mahmoodzadeh

Jannat

et al. 2019

Polymers for Advanced Techs

Self Cite

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“…Long persistent luminescence material (LPL) is a kind of green energy storage material, ascribed to its high luminous efficiency, excellent long persistent luminescent property, chemical stability, and nonradioactive property . Therefore, it has been widely used in such areas as emergency escape signs, optical detectors, security features, drug tracers, and luminous paint . In recent years, the research on LPL has been increasing, especially aluminates like SrAl 2 O 4 .…”

Section: Introductionmentioning

confidence: 99%

Phosphor powders‐incorporated polylactic acid polymeric composite used as 3D printing filaments with green luminescence properties

Wan

Jiang

Nie

et al. 2019

J of Applied Polymer Sci

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A new class of multifunctional nanocomposites holds strong potential in three-dimensional (3D) printing. In this study, SrAl 2 O 4 :Eu 2+ ,Dy 3+ powders with fluorescence property were modified with SiO 2 to improve its dispersibility and compatibility in the polylactic acid (PLA) matrix. The composite filaments with a diameter of 1.75 AE 0.05 mm containing 2 wt % of modified particles were prepared by a melt blending method. The fluorescent analysis reveals that the composite filaments can be excited by light with a broad band of wavelength from 345 to 455 nm with the highest excitation intensity at 426 nm and have a major emission peak at 487 nm. The morphological analysis and mechanical performance testing on the printed samples showed that modified particles were uniformly dispersed within the PLA matrix and improved the mechanical properties of the composite filaments. Moreover, the modified particles improved hydrophobic behavior and antibacterial properties in comparison with unmodified composite. Therefore, the composite material will have potential applications such as making prototypes for customized furniture and accessories by 3D printing technology.

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Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing

Giovannini,

Sharma,

Boesel

et al. 2023

Adv Healthcare Materials

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Chronic wounds are regarded as a silent epidemic, affecting 1–2% of the population and representing 2–4% of healthcare expenses. The current methods used to assess the wound healing process are based on the visual evaluation of physical parameters. This work aims to design a wearable non‐invasive device capable of evaluating three parameters simultaneously: the pH and the levels of glucose and matrix metalloproteinase (MMP) present in the wound exudate. The device is composed of three independent polymer optical fibers functionalized with fluorescent‐based sensing chemistries specific to the targeted analytes. Each fiber is characterized in terms of detection sensitivity and selectivity confirming their suitability for monitoring the targeted parameters in ranges relevant to the wound environment. The selectivity and robustness of the multi‐sensing device are confirmed with analyses using complex solutions with different pH levels (5, 6, and 7), different concentrations of glucose (1.25, 2.5, and 5 mm), and MMP (1.25, 2.5, and 5 µg mL−1). Given the simple set‐up, the affordability of the materials used and the possibility of detecting additional parameters relevant to wound healing, such multi‐sensing fiber‐based devices could pave the way for novel non‐invasive wearable tools enabling the assessment of wound healing from the molecular perspective.

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Development of biocompatible fluorescent gelatin nanocarriers for cell imaging and anticancer drug targeting

Cited by 57 publications

References 47 publications

Glutathione and pH‐responsive fluorescent nanogels for cell imaging and targeted methotrexate delivery

Glutathione and pH‐responsive fluorescent nanogels for cell imaging and targeted methotrexate delivery

Phosphor powders‐incorporated polylactic acid polymeric composite used as 3D printing filaments with green luminescence properties

Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing

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